Patents by Inventor Jay Duffner

Jay Duffner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Compositions for the Diagnosis and Treatment of Kawasaki Disease
    Publication number: 20210116462
    Abstract: The present invention relates to the determination of levels or expression of particular biomarkers in biological samples which can be utilized to diagnose, prognose, and treat Kawasaki disease in subjects, and further to select subjects who would benefit from a Kawasaki disease therapy other than, or in addition to, IVIG treatment. Accordingly, the present invention encompasses methods and compositions that utilize these biomarkers for the diagnosis, prognosis, and treatment of Kawasaki disease.
    Type: Application
    Filed: April 6, 2020
    Publication date: April 22, 2021
    Inventors: Dorota A. Bulik, Carlos J. Bosques, Jay Duffner, Leona E. Ling, Hetal Sarvaiya
  • VARIANT-SPECIFIC ALIGNMENT OF NUCLEIC ACID SEQUENCING DATA
    Publication number: 20200058375
    Abstract: Techniques and systems for determining a correct alignment of nucleic acid sequences are described. Determining the correct alignment may include generating multiple reference sequences that include one or more variants and aligning the nucleic acid sequences to the multiple reference sequences. The correct alignment may include performing an alignment of the nucleic acid sequences using the multiple reference sequences and determining the correct alignment for the nucleic acid sequences based at least in part on a result of the alignment using the multiple reference sequences.
    Type: Application
    Filed: February 23, 2018
    Publication date: February 20, 2020
    Inventor: Jay Duffner
  • High mannose glycans
    Patent number: 9921210
    Abstract: Methods and compositions related to high mannose glycans are described.
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: March 20, 2018
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Brian Edward Collins, Jay Duffner, Carlos J. Bosques, Dorota A. Bulik, James Myette, James Meador
  • N-acetylhexosamine-containing N-glycans in glycoprotein products
    Patent number: 9890410
    Abstract: The present invention provides methods of evaluating a glycoprotein preparation for the absence, presence or amount of an N-acetylhexosamine glycan, e.g., an N-acetylglucosamine glycan.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: February 13, 2018
    Assignee: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Nathaniel Washburn, Enrique Arevalo, Kevin Millea, Carlos J. Bosques, Jay Duffner, Brian Edward Collins
  • METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF KAWASAKI DISEASE
    Publication number: 20170052200
    Abstract: The present invention relates to the determination of levels or expression of particular biomarkers in biological samples which can be utilized to diagnose, prognose, and treat Kawasaki disease in subjects, and further to select subjects who would benefit from a Kawasaki disease therapy other than, or in addition to, IVIG treatment. Accordingly, the present invention encompasses methods and compositions that utilize these biomarkers for the diagnosis, prognosis, and treatment of Kawasaki disease.
    Type: Application
    Filed: May 1, 2015
    Publication date: February 23, 2017
    Inventors: Dorota A. BULIK, Jay DUFFNER, Leona E. LING, Hetal SARVAIYA, Carlos J. BOSQUES
  • N-ACETYLHEXOSAMINE-CONTAINING N-GLYCANS IN GLYCOPROTEIN PRODUCTS
    Publication number: 20160060675
    Abstract: The present invention provides methods of evaluating a glycoprotein preparation for the absence, presence or amount of an N-acetylhexosamine glycan, e.g., an N-acetylglucosamine glycan.
    Type: Application
    Filed: September 9, 2015
    Publication date: March 3, 2016
    Inventors: Nathaniel Washburn, Enrique Arevalo, Kevin Millea, Carlos J. Bosques, Jay Duffner, Brian Edward Collins
  • N-acetylhexosamine-containing N-glycans in glycoprotein products
    Patent number: 9170249
    Abstract: The present invention provides methods of evaluating a glycoprotein preparation for the absence, presence or amount of an N-acetylhexosamine glycan, e.g., an N-acetylglucosamine glycan.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: October 27, 2015
    Assignee: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Nathaniel J. Washburn, Enrique Arevalo, Kevin Millea, Carlos J. Bosques, Jay Duffner, Brian E. Collins
  • HIGH MANNOSE GLYCANS
    Publication number: 20130231255
    Abstract: Methods and compositions related to high mannose glycans are described.
    Type: Application
    Filed: April 7, 2011
    Publication date: September 5, 2013
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Brian Edward Collins, Jay Duffner, Carlos J. Bosques, Dorota A. Bulik, James Myette, James Meador
  • SELECTION AND USE OF HOST CELLS FOR PRODUCTION OF GLYCOPROTEINS
    Publication number: 20130123126
    Abstract: A method of making a glycoprotein having a selected glycostructure.
    Type: Application
    Filed: April 7, 2011
    Publication date: May 16, 2013
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Brian Edward Collins, Jay Duffner, Victor Farutin, Naveen Bhatnagar, Lakshmanan Thiruneelakantapillai, Carlos J. Bosques, Ganesh Kaundinya
  • N-ACETYLHEXOSAMINE-CONTAINING N-GLYCANS IN GLYCOPROTEIN PRODUCTS
    Publication number: 20120295273
    Abstract: The present invention provides methods of evaluating a glycoprotein preparation for the absence, presence or amount of an N-acetylhexosamine glycan, e.g., an N-acetylglucosamine glycan.
    Type: Application
    Filed: March 12, 2012
    Publication date: November 22, 2012
    Inventors: Nathaniel J. Washburn, Enrique Arevalo, Kevin Millea, Carlos J. Bosques, Jay Duffner, Brian E. Collins
  • METHODS OF ASSESSING ACTIVITY OF A POLYSACCHARIDE COMPOSITION
    Publication number: 20120183976
    Abstract: Methods of assessing polysaccharide preparations lacking substantial anticoagulant activity are provided herein.
    Type: Application
    Filed: April 16, 2010
    Publication date: July 19, 2012
    Inventors: He Zhou, Jay Duffner, Zoya Galcheva-Gargova, Takashi Kei Kishimoto, Birgit Schultes
  • Process for removing microbubbles from a liquid
    Publication number: 20070119774
    Abstract: A process is provided for removing microbubbles from a liquid by filtration with a composite porous membrane which is formed from a porous polymeric membrane having an average pore size between about 0.01 and 0.03 microns on which is directly coated a cross-linked polymer derived from N,N-methylenebisacrylamide (MBAM) optionally containing dimethylacrylamide (DMAM).
    Type: Application
    Filed: January 11, 2005
    Publication date: May 31, 2007
    Inventors: Larry Yen, Jay Duffner, Saksatha Ly