Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: A systems for detecting level sensor malfunction or tampering based on reductant consumption and determining when to initiate a quality check of reductant used in an aftertreatment system are disclosed. The system comprises a memory storing instructions and a processor executing the instructions to perform a process including: receiving dosing data associated with an amount of DEF supplied to the aftertreatment system; receiving tank level data from a level sensor in a DEF tank; comparing the dosing data with the tank level data; and based on the comparison: initiating, by the one or more processors, a quality check; and/or determining, by the one or more processors, a possible error requiring further diagnostics; and causing to present, by the one or more processors, an indication that the quality check is being initiated and/or that a possible error requires further diagnostics on a display.

Abstract: Disclosed is a target-based drug screening method using inverse quantitative structure-(drug)performance relationships (QSPR) analysis and molecular dynamics simulation. The method includes modeling a molecular structure of a test compound group against a target molecule, obtaining a quantitative structure-(drug)performance relationships (QSPR) of the test compound group, acquiring the optimal pharmacophore of a novel target-based drug through a numerical inversion of the QSPR, and selecting drug candidates having a molecular structure similar to the optimum pharmacophore from the test compound group.

Abstract: Disclosed is a method for predicting an elution order of compounds in a mixture. The method includes (a) building a quantitative structure-retention relationship (QSRR) model and (b) predicting a chromatographic elution order of the compounds in the mixture on the basis of the QSRR model using mathematical programming. The mathematical programming is a non-linear programming technique in which a predicted elution order of the compounds is used as a constraint or a multi-objective optimization (MOO) in which a retention time prediction error and an elution order prediction error are used as objective functions. With the use of the method of the present disclosure, it is possible to optimize separation of complex mixtures in reversed-phase chromatography by enabling identification of accurate positions of individual compounds that provides higher certainty in identifying a given compound, e.g., during an “omics” analysis (proteomics, metabolomics, etc.).

Abstract: The present invention relates to a method for reducing the complexity of bio-crudes. The method includes (a) obtaining experimental data of quantitative and qualitative analyses for the bio-crudes, (b) grouping compounds contained in the bio-crudes according to a predetermined basis based on the experimental data, (c) selecting representative compounds from among the compounds belonging to the same group, and (d) reconstituting the bio-crudes as a mixture of the representative compounds.

Abstract: The present invention is directed to multi-layered wound dressings having a carrier layer, at least two sublayers, wherein each sublayer contains at least one reactive, cross-linkable component and the at least two reactive, cross-linkable components are co-reactive with the other and at least one reactive, cross-linkable has a protective leaving group and a buffering salt agent.

Abstract: Disclosed is a method for predicting an elution order of compounds in a mixture. The method includes (a) building a quantitative structure-retention relationship (QSRR) model and (b) predicting a chromatographic elution order of the compounds in the mixture on the basis of the QSRR model using mathematical programming. The mathematical programming is a non-linear programming technique in which a predicted elution order of the compounds is used as a constraint or a multi-objective optimization (MOO) in which a retention time prediction error and an elution order prediction error are used as objective functions. With the use of the method of the present disclosure, it is possible to optimize separation of complex mixtures in reversed-phase chromatography by enabling identification of accurate positions of individual compounds that provides higher certainty in identifying a given compound, e.g., during an “omics” analysis (proteomics, metabolomics, etc.).

Abstract: Disclosed is a target-based drug screening method using inverse quantitative structure-(drug)performance relationships (QSPR) analysis and molecular dynamics simulation. The method includes modeling a molecular structure of a test compound group against a target molecule, obtaining a quantitative structure-(drug)performance relationships (QSPR) of the test compound group, acquiring the optimal pharmacophore of a novel target-based drug through a numerical inversion of the QSPR, and selecting drug candidates having a molecular structure similar to the optimum pharmacophore from the test compound group.

Abstract: The present invention relates to a method for reducing the complexity of bio-crudes. The method includes (a) obtaining experimental data of quantitative and qualitative analyses for the bio-crudes, (b) grouping compounds contained in the bio-crudes according to a predetermined basis based on the experimental data, (c) selecting representative compounds from among the compounds belonging to the same group, and (d) reconstituting the bio-crudes as a mixture of the representative compounds. In the method for reducing the complexity of the bio-crudes for process simulation according to the present invention, the number of constituent compounds of the bio-crudes is minimized and the physical properties of the bio-crudes are accurately represented using only experimental data obtained through GC-MS, thereby enabling accurate and efficient process simulation of the bio-crudes.

Abstract: The present disclosure is directed to an LED engine comprising an LED light emitting board, a first circuit board, and a second circuit board. The LED light emitting board and two circuit boards are electrically connected via array cables. Either the first circuit board or the second circuit board has a linear LED driver IC. The first circuit board and the second circuit board, in combination, are configured to receive an AC line voltage, and drive the LED light emitting board. In some implementations, LEDs connected to the LED light emitting board are divided into two or more sections, each of which has a different correlated color temperature (CCT) to achieve CCT tuning. In some implementations, the LED engine further comprises a light engine housing.

Abstract: Techniques and systems are described that enable multiple current source prioritization with overvoltage protection.

Abstract: Techniques and systems are described that enable multiple current source prioritization with overvoltage protection.

Abstract: The present disclosure is directed to an LED engine comprising an LED light emitting board, a first circuit board, and a second circuit board. The LED light emitting board and two circuit boards are electrically connected via array cables. Either the first circuit board or the second circuit board has a linear LED driver IC. The first circuit board and the second circuit board, in combination, are configured to receive an AC line voltage, and drive the LED light emitting board. In some implementations, LEDs connected to the LED light emitting board are divided into two or more sections, each of which has a different correlated color temperature (CCT) to achieve CCT tuning. In some implementations, the LED engine further comprises a light engine housing.

Abstract: A method and user interface is provided for use on a computer system coupled with a scanner for performing an automatic scan operation on an original document, with the computer system running a scanner driver and an application program. By the method and user interface, the scanner is first activated to perform a primitive scan operation on the original document based on the default image processing settings to thereby obtain a primitive scanned image. Next, the scanner driver is activated to perform a set of image processing routines on the primitive scanned image to thereby obtain the image qualities of the original document; and based on the image qualities of the original document, a set of suited image processing settings are specified for optimal scan of the original document.

Abstract: A new application of machine vision for process industries is proposed. The invention consists of: (1) estimation of visual quality of products, (2) modeling causal relationship between estimated quality and process variables, and (3) optimization of visual quality using the causal model. This invention can handle the stochastic nature in visual appearance of products that process industries provide, which has been a main obstacle for the success of machine vision in process industries. Also, it opens new tasks in machine vision such as modeling and optimization of visual quality of products.

Abstract: Assays for detecting or measuring inositol phosphate, for detecting or measuring signaling pathways, for detecting or measuring the activity of phospholipase C-linked receptors and/or their cognate pathways, for detecting or measuring the activity of inositol kinases and inositol phosphatases, and for screening for compounds that modulate the activity of signaling pathways, receptors and enzymes.

Abstract: Magnetic recording media having a protective carbon overcoat adapted to protect the magnetic recording layer from surface contact events and corrosion. The carbon overcoat includes at least two layers. A first layer is adapted to protect the magnetic recording layer from surface contact events and corrosion. The second layer is disposed on the first layer and is adapted to enhance the bonding of a lubricant to the carbon overcoat and to minimize head degradation. The magnetic recording media of the present invention advantageously enables the use of thin carbon overcoats, enhancing areal density, while maintaining good tribological properties.

Abstract: An antenna suitable for use in a Radio Frequency Identification (RFID) tag is disclosed. The antenna includes a plurality of discrete loop antennas (130, 140, 150) disposed concentrically on a substrate. Each one of said plurality of loop antennas is electrically isolated from each other one of said plurality of loop antennas.

Abstract: A method and user interface is provided for use on a computer system coupled with a scanner for performing a scan operation on an original document, which allows the user to acquire scanned images in an easier and more user-friendly manner. The method allows the user to scan an original document without requiring the user to have learned knowledge a background in the science of image processing, and also allows the scanner to perform only one scan operation on the original document. These features allow the use of the scanner to be easier and more user-friendly than the prior art. By the, method, the first step is to determine In the method, first a scanner driver program suited for optimizing the scan of the original document determines a set of image processing settings by a scanner driving program that are suited for optimal scan of the original document; and then.

Abstract: A method and user interface is provided for use on a computer system coupled with a scanner for performing a scan operation on an original document, which allows the user to acquire scanned images in an easier and more user-friendly manner. The method allows the user to scan an original document without requiring the user to have learned knowledge background in the science of image processing, and also allows the scanner to perform only one scan operation on the original document. These features allow the use of the scanner to be easier and more user-friendly than the prior art. By the, method, the first step is to determine a set of image processing settings by a scanner driving program that are suited for optimal scan of the original document; and then the scanner is activated to perform a scan operation on the original document based on the image processing settings to thereby obtain a primitive scanned image.