Abstract: Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.

Abstract: Embodiments described herein relate to systems, devices, and methods for use in the implementation of a brain-computer interface that integrates real-time eye-movement tracking with brain activity tracking to present and update a user interface that is strategically designed for high speed and accuracy of human-machine interaction. Embodiments described herein also relate to the implementation of a hardware agnostic brain-computer interface that uses real-time eye tracking and online analysis of neural signals to mediate user manipulation of machines.

Abstract: An aerosolizable formulation having one or more aerosol-forming agents; and nicotine; wherein the nicotine includes (R)-nicotine in an amount of from about 1% to about 4.5% by weight of the total nicotine.

Abstract: Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.

Abstract: The present disclosure relates to, inter alia, RNA molecules (e.g., RNA hairpin agonists) that bind to and agonize RIG-I-like receptors (RLRs), and to use of the molecules, including RLR agonists packaged in vims like particles (VLPs), in methods for treating, or ameliorating one or more symptoms of, a disorder (e.g., cancer).

Abstract: The present disclosure relates to, inter alia, RNA molecules (e.g., RNA hairpin agonists) that bind to and agonize RIG-I-like receptors (RLRs), and to use of the molecules in methods for treating, or ameliorating one or more symptoms of, a disorder (e.g., cancer).

Abstract: The present disclosure relates to, inter alia, RNA molecules (e.g., RNA hairpin agonists) that bind to and agonize RIG-I-like receptors (RLRs), and to use of the molecules in methods for treating, or ameliorating one or more symptoms of, a disorder (e.g., cancer).

Abstract: Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.

Abstract: The present disclosure relates to, inter alia, RNA molecules (e.g., RNA hairpin agonists) that bind to and agonize RIG-I-like receptors (RLRs), and to use of the molecules in methods for treating, or ameliorating one or more symptoms of, a disorder (e.g., cancer).

Abstract: Among other things, the present disclosure pertains to methods and compositions related to phasing of allelic variants of genetic loci. Phasing of allelic variants of genetic loci on an individual patient's chromosomes is highly valuable for many purposes, including patient stratification for allele-specific therapeutics.

Abstract: Low frequency alarm tones emitted by life safety devices are more likely to notify sleeping children and the elderly. Disclosed herein is a life safety device equipped with a novel, compact, circumferential resonant cavity which increases the low frequency (400-600 Hz square wave) acoustic efficiency of an audio output apparatus formed by acoustically coupling an audio output transducer to the resonant cavity.

Abstract: Low frequency alarm tones emitted by life safety devices are more likely to notify sleeping children and the elderly. Disclosed herein is a life safety device equipped with a novel, compact, circumferential resonant cavity which increases the low frequency (400-600 Hz square wave) acoustic efficiency of an audio output apparatus formed by acoustically coupling an audio output transducer to the resonant cavity. The resonant cavity is a compact circumferential acoustic resonator with a captured mass of air within a ring shaped cavity significantly reducing the overall size of the resonator, thereby permitting the audio output apparatus to fit within the housing of conventional size life safety devices such as, but not limited to, residential and commercial smoke alarms and carbon monoxide alarms. The compact resonator is an acoustic compliant cavity with internal passages transforming axial traveling sound waves to circumferentially traveling sound waves thereby yielding a very compact geometry.

Abstract: Low frequency alarm tones emitted by life safety devices are more likely to notify sleeping children and the elderly. Disclosed herein is a life safety device equipped with a novel, compact, circumferential resonant cavity which increases the low frequency (400-600 Hz square wave) acoustic efficiency of an audio output apparatus formed by acoustically coupling an audio output transducer to the resonant cavity.

Abstract: Low frequency alarm tones emitted by life safety devices are more like to notify sleeping children and the elderly. Disclosed herein is a life safety device equipped with a novel, compact, quarter-wave, folded resonant cavity which significantly increases the low frequency (400-700 Hz square wave) acoustic efficiency of an audio output transducer when the folded resonant cavity is acoustically coupled to the transducer forming an audio output apparatus. The folded resonant cavity is comprised of undulating, annular, acoustic passages to significantly reduce the length of the resonant cavity, thereby permitting the audio output apparatus to fit within the housing of conventional size life safety devices such as, but not limited to, residential and commercial smoke alarms and carbon monoxide alarms. Battery powered embodiments of the audio output apparatus comprising a folded resonant cavity passed audibility tests for low frequency alarm tones in smoke alarms specified by UL217.

Abstract: Low frequency alarm tones emitted by life safety devices are more likely to notify sleeping children and the elderly. Disclosed herein is a life safety device equipped with a novel, compact, circumferential resonant cavity which increases the low frequency (400-600 Hz square wave) acoustic efficiency of an audio output apparatus formed by acoustically coupling an audio output transducer to the resonant cavity. The resonant cavity is a compact circumferential acoustic resonator with a captured mass of air within a ring shaped cavity significantly reducing the overall size of the resonator, thereby permitting the audio output apparatus to fit within the housing of conventional size life safety devices such as, but not limited to, residential and commercial smoke alarms and carbon monoxide alarms. The compact resonator is an acoustic compliant cavity with internal passages transforming axial traveling sound waves to circumferentially traveling sound waves thereby yielding a very compact geometry.

Abstract: A medical fluid delivery cassette configured for use with a medical fluid pumping system. The cassette includes a base, a membrane attached to the base, and an adhesive disposed on a portion of the membrane overlying a fluid pump chamber of the cassette. The portion of the membrane overlying the fluid pump chamber is moveable such that the volume of the fluid pump chamber can be changed.

Abstract: Low frequency alarm tones emitted by life safety devices are more likely to notify sleeping children and the elderly. Disclosed herein is a life safety device equipped with a novel, compact, circumferential resonant cavity which increases the low frequency (400-600 Hz square wave) acoustic efficiency of an audio output apparatus formed by acoustically coupling an audio output transducer to the resonant cavity. The resonant cavity is a compact circumferential acoustic resonator with a captured mass of air within a ring shaped cavity significantly reducing the overall size of the resonator, thereby permitting the audio output apparatus to fit within the housing of conventional size life safety devices such as, but not limited to, residential and commercial smoke alarms and carbon monoxide alarms. The compact resonator is an acoustic compliant cavity with internal passages transforming axial traveling sound waves to circumferentially traveling sound waves thereby yielding a very compact geometry.

Abstract: Low frequency alarm tones emitted by life safety devices are more like to notify sleeping children and the elderly. Disclosed herein is a life safety device equipped with a novel, compact, quarter-wave, folded resonant cavity which significantly increases the low frequency (400-700 Hz square wave) acoustic efficiency of an audio output transducer when the folded resonant cavity is acoustically coupled to the transducer forming an audio output apparatus. The folded resonant cavity is comprised of undulating, annular, acoustic passages to significantly reduce the length of the resonant cavity, thereby permitting the audio output apparatus to fit within the housing of conventional size life safety devices such as, but not limited to, residential and commercial smoke alarms and carbon monoxide alarms. Battery powered embodiments of the audio output apparatus comprising a folded resonant cavity passed audibility tests for low frequency alarm tones in smoke alarms specified by UL217.

Abstract: An environmental condition detector emits only safe, validated verbal messages recorded in a user's voice to help occupants of a building respond safely to sensed environmental conditions. The message emitted in the user's voice is generally a familiar voice to other building occupants to better capture their attention, and only certain, safe, user messages are validated for use thereby eliminating the chance that the user may unknowingly record an unsafe message to be emitted during a sensed environmental condition. The verbal message is recorded by a user and is analyzed through speech recognition to determine if the user-recorded message can be validated as containing safe content. A user-recorded message found to match manufacturer preprogrammed message content is validated and selected to be audibly emitted in the user's voice when an environmental condition is sensed. Various embodiments include single station units, interconnected units, or centrally controlled security systems.

Abstract: An environmental condition detector emits only safe, validated verbal messages recorded in a user's voice to help occupants of a building respond safely to sensed environmental conditions. The message emitted in the user's voice is generally a familiar voice to other building occupants to better capture their attention, and only certain, safe, user messages are validated for use thereby eliminating the chance that the user may unknowingly record an unsafe message to be emitted during a sensed environmental condition. The verbal message is recorded by a user and is analyzed through speech recognition to determine if the user-recorded message can be validated as containing safe content. A user-recorded message found to match manufacturer preprogrammed message content is validated and selected to be audibly emitted in the user's voice when an environmental condition is sensed. Various embodiments include single station units, interconnected units, or centrally controlled security systems.