Patents by Inventor Jay R. Knutson
Jay R. Knutson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9448158Abstract: Light collectors for fluorescence microscopy include slab light guides having a specimen volume such as a specimen well configured to retain a specimen. The specimen volume is bounded by a surface of the slab light guide that permits laterally propagating fluorescence to enter the slab light guide and propagate toward a detection or imaging system. Typically, the slab light guide has an elliptical perimeter and the sample volume is situated at a first focus of the elliptical perimeter. A reflector such as a conical reflector is situated at the second focus so as to direct the collected fluorescence to exit the slab light guide.Type: GrantFiled: February 3, 2012Date of Patent: September 20, 2016Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Jay R. Knutson, Christian A. Combs, Robert S. Balaban
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Patent number: 9273089Abstract: Composite probes for super resolution optical techniques using super resolution via transiently activated quenchers (STAQ) include a donor moiety and an acceptor moiety joined by a linker, wherein the acceptor moiety, when excited by incident radiation, is excited to a state which, for example, absorbs in the donor emission region, such that the acceptor moiety in its excited state quenches at least a portion of the donor moiety emission. Other transiently activated quenching mechanisms and moieties could accomplish the same task by reducing donor population. Also disclosed are methods for irradiating a selected region of a target material including the composite probe, wherein the composite probe enables improved resolution by point spread function modification and/or nanoscale chemical reactions.Type: GrantFiled: August 15, 2013Date of Patent: March 1, 2016Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Jay R. Knutson, Gary L. Griffiths
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Patent number: 9086509Abstract: Polarizers and polarizing beam splitter include one or more pairs of axicons that are configured to separate an input beam into a radially polarized component and a tangentially (or azimuthally) polarized component. A second axicon pair can be provided to recombine the tangentially polarized component so as to provide a more uniform beam intensity. The radially polarized component can be reflected or otherwise directed so that one or both the radial and tangential components are available for use.Type: GrantFiled: February 22, 2011Date of Patent: July 21, 2015Assignee: The United States of America as represented by the Secretary, Department of Health and Human ServicesInventor: Jay R. Knutson
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Patent number: 8759792Abstract: A multi-photon microscope having an illumination source that transmits an illumination light into a housing having an objective lens arrangement for illuminating a sample disposed outside the housing and directing a first portion of emission light emitted from the sample to a detection system is disclosed. A light collection system is disposed proximate the objective lens arrangement for directing a second portion of emission light in a coaxial relationship with the first portion of emission light to the detection system such that substantially all of the emission light on, around and above the illumination region is detected.Type: GrantFiled: July 12, 2010Date of Patent: June 24, 2014Assignee: The United States of America, as Represented by the Secretary, Dept. of Health and Human ServicesInventors: Jay R. Knutson, Christian A. Combs, Robert S. Balaban
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Publication number: 20130345391Abstract: Composite probes for super resolution optical techniques using super resolution via transiently activated quenchers (STAQ) include a donor moiety and an acceptor moiety joined by a linker, wherein the acceptor moiety, when excited by incident radiation, is excited to a state which, for example, absorbs in the donor emission region, such that the acceptor moiety in its excited state quenches at least a portion of the donor moiety emission. Other transiently activated quenching mechanisms and moieties could accomplish the same task by reducing donor population. Also disclosed are methods for irradiating a selected region of a target material including the composite probe, wherein the composite probe enables improved resolution by point spread function modification and/or nanoscale chemical reactions.Type: ApplicationFiled: August 15, 2013Publication date: December 26, 2013Applicant: The United States of America, as represented by the Secretary, Department of Health and Human ServInventors: Jay R. Knutson, Gary L. Griffiths
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Publication number: 20130308126Abstract: Light collectors for fluorescence microscopy include slab light guides having a specimen volume such as a specimen well configured to retain a specimen. The specimen volume is bounded by a surface of the slab light guide that permits laterally propagating fluorescence to enter the slab light guide and propagate toward a detection or imaging system. Typically, the slab light guide has an elliptical perimeter and the sample volume is situated at a first focus of the elliptical perimeter. A reflector such as a conical reflector is situated at the second focus so as to direct the collected fluorescence to exit the slab light guide.Type: ApplicationFiled: February 3, 2012Publication date: November 21, 2013Applicant: The United States of America, as represented by the Secretary, Dept of Health and Human ServicesInventors: Jay R. Knutson, Christian A. Combs, Robert S. Balaban
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Patent number: 8547533Abstract: Composite probes for super resolution optical techniques using super resolution via transiently activated quenchers (STAQ) include a donor moiety and an acceptor moiety joined by a linker, wherein the acceptor moiety, when excited by incident radiation, is excited to a state which, for example, absorbs in the donor emission region, such that the acceptor moiety in its excited state quenches at least a portion of the donor moiety emission. Other transiently activated quenching mechanisms and moieties could accomplish the same task by reducing donor population. Also disclosed are methods for irradiating a selected region of a target material including the composite probe, wherein the composite probe enables improved resolution by point spread function modification and/or nanoscale chemical reactions.Type: GrantFiled: December 28, 2010Date of Patent: October 1, 2013Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Jay R. Knutson, Gary L. Griffiths
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Publication number: 20130153788Abstract: A multi-photon microscope having an illumination source that transmits an illumination light into a housing having an objective lens arrangement for illuminating a sample disposed outside the housing and directing a first portion of emission light emitted from the sample to a detection system is disclosed. A light collection system is disposed proximate the objective lens arrangement for directing a second portion of emission light in a coaxial relationship with the first portion of emission light to the detection system such that substantially all of the emission light on, around and above the illumination region is detected.Type: ApplicationFiled: July 12, 2010Publication date: June 20, 2013Applicant: The Govt. of the United States of America, as represented by the Secretary, D.H.H.S.Inventors: Jay R. Knutson, Christian A. Combs
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Publication number: 20120320458Abstract: Polarizers and polarizing beam splitter include one or more pairs of axicons that are configured to separate an input beam into a radially polarized component and a tangentially (or azimuthally) polarized component. A second axicon pair can be provided to recombine the tangentially polarized component so as to provide a more uniform beam intensity. The radially polarized component can be reflected or otherwise directed so that one or both the radial and tangential components are available for use.Type: ApplicationFiled: February 22, 2011Publication date: December 20, 2012Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVInventor: Jay R. Knutson
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Publication number: 20120309045Abstract: Composite probes for super resolution optical techniques using super resolution via transiently activated quenchers (STAQ) include a donor moiety and an acceptor moiety joined by a linker, wherein the acceptor moiety, when excited by incident radiation, is excited to a state which, for example, absorbs in the donor emission region, such that the acceptor moiety in its excited state quenches at least a portion of the donor moiety emission. Other transiently activated quenching mechanisms and moieties could accomplish the same task by reducing donor population. Also disclosed are methods for irradiating a selected region of a target material including the composite probe, wherein the composite probe enables improved resolution by point spread function modification and/or nanoscale chemical reactions.Type: ApplicationFiled: December 28, 2010Publication date: December 6, 2012Inventors: Jay R. Knutson, Gary L. Griffiths
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Patent number: 7667210Abstract: A multi-photon microscope has an illumination source, an objective lens unit arranged in an optical path of the illumination source, a first light collection system arranged to collect a first portion of light emitted from a sample when the sample is illuminated by light from the illumination source, and a second light collection system arranged to collect a second portion of light emitted from the sample when the sample is illuminated by light from the illumination source. The first portion of light when collected by the first light collection system and the second portion of light when collected by the second light collection system, together provide a means of collecting as much light from as many angles as possible emanating from an emitting point source. This collection scheme has the potential to approach the total emission collection of light from an emitting point source depending on the optical properties of the sample being imaged.Type: GrantFiled: November 6, 2007Date of Patent: February 23, 2010Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Robert S. Balaban, Christian A. Combs, Jay R. Knutson
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Patent number: 5416582Abstract: An apparatus and method for using frequency modulated diffusive photon-density waves propagating through a turbid medium such as tissue for detecting optical properties of objects and for imaging objects within the turbid medium. Frequency modulation enables real time differential measurement of the interaction of different colors with the object when the different colors are chosen such that they react the same with the medium but differently with the object. The method greatly simplifies optical imaging and increases the amount of information which may be obtained about the object.Type: GrantFiled: February 11, 1993Date of Patent: May 16, 1995Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Jay R. Knutson, Alexander Knuttel, Joseph M. Schmitt
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Patent number: 5203339Abstract: Imaging of a turbid object utilizes interference among the modulation wavefronts of a plurality of modulated light rays propagating through the object by diffusion and having predetermined phases relative to one another. A computer controlled phase and amplitude selecting device, such as a zone plate, is used to modulate light rays at appropriate phases in order to obtain constructive interference only at a predetermined portion of the object, including one or more preselected voxels. The rays reflected from (or diffusively transmitted through) the predetermined portion are received simultaneously at a detector, thus providing simultaneously all the data necessary to describe or image the portion. A single detector element may be used to detect the scattered reflected or transmitted light from the portion and to generate a signal representing the amplitude and phase characteristics for the modulation wavefront, thereby to provide absorption (and other) characteristics descriptive of the portion.Type: GrantFiled: June 28, 1991Date of Patent: April 20, 1993Assignee: The Government of the United States of America as represented by the Secretary of the Department Health and Human ServicesInventors: Alexander Knuttel, Jay R. Knutson