Abstract: Provided are antibodies that specifically bind to CTLA-4 and/or PD-1 and antagonize CTLA-4 and/or PD-1 function. Also provided are pharmaceutical compositions and kits comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies either alone or in combination.

Abstract: A chassis assembly includes a rack chassis and a block assembly. The rack chassis includes a left side panel and a right side panel that are made from one continuous single material. The left side panel includes a left rail guide, and the right side panel includes a right rail guide. The block assembly is adapted to slide into the rack chassis and includes a top cover, a left sidewall, and a right sidewall that are interconnected. The left sidewall of the block assembly includes a left rail adapted to slide into the left rail guide when the block assembly is located leftmost of the rack chassis. The right sidewall of the block assembly includes a right rail that is adapted to slide into the right rail guide when the block assembly is located rightmost of the rack chassis.

Abstract: An interactive system may be implemented in part by an audio device located within a user environment, which may accept speech commands from a user and may also interact with the user by means of generated speech. In order to improve performance of the interactive system, a user may use a separate device, such as a personal computer or mobile device, to access a graphical user interface that lists details of historical speech interactions. The graphical user interface may be configured to allow the user to provide feedback and/or corrections regarding the details of specific interactions.

Abstract: Resuscitation and ventilation monitoring devices are provided. A device includes an inlet in fluid communication with airflows exchanged with lungs of a patient and an airflow meter for measuring characteristics of the airflows. A user may provide a controller with patient information, e.g., height, weight, gender, or age, via a measurement selector, enabling the controller to determine acceptable ranges of measured airflow characteristics. The device may determine a current mode of ventilation and associated ventilator settings based on the measured airflow characteristics. The device may also identify and filter out artifacts present in the ventilation signal, and determine whether a respiratory failure phenotype is present in the ventilation. If the current mode of ventilation and associated ventilator settings fall outside an acceptable range, the ventilation is classified as off-target and the controller may cause a sensory alarm to alert the user.

Abstract: A precursor mixture for producing a porous body, wherein the precursor mixture comprises: (i) at least one milled alpha alumina powder having a particle size of 0.1 to 6 microns, (ii) non-silicate powder that functions as a binder of the alpha alumina powders, and (iii) at least one burnout material having a particle size of 1-10 microns and a decomposition temperature of less than 550° C., with the proviso that a burnout material having a decomposition temperature of 550° C. or greater is excluded from the precursor mixture.

Abstract: A precursor mixture for producing a porous body, wherein the precursor mixture comprises: (i) at least one milled alpha alumina powder having a particle size of 0.1 to 6 microns, (ii) non-silicate powder that functions as a binder of the alpha alumina powders, and (iii) at least one burnout material having a particle size of 1-10 microns and a decomposition temperature of less than 550° C., with the proviso that a burnout material having a decomposition temperature of 550° C. or greater is excluded from the precursor mixture.

Abstract: Oxalic acid is employed in a precursor mixture containing at least one milled alpha alumina powder having a particle size of 0.1 to 6 microns, boehmite powder that functions as a binder of the alpha alumina powders, and at least one burnout material having a particle size of 1-10 microns to provide a porous body having enhanced pore architecture in which extrusion cracks can be reduced. The presence of oxalic acid in such as precursor mixture can reduce and even eliminate NOx emission during a high temperature heat treatment process.

Abstract: Systems and methods for providing users with a real time or near-real time indications of media channels or programs that are currently receiving the most usage or consumption within a defined population of users are disclosed. In an embodiment, a method receives media usage data for currently airing media while the media is being aired and creates an ordered list of media channels or programs for presentation, based at least in part on the media usage data. The method then presents the ordered list of media channels or programs while the media is being aired. In an embodiment, a system further provides the ability to easily select and tune one of the indicated channels or programs in an interactive interface. In an embodiment, the selected media channels or programs are sold on demand or as part of a service upgrade if they are not included in a user's current subscription.

Abstract: Oxalic acid is employed in a precursor mixture containing at least one milled alpha alumina powder having a particle size of 0.1 to 6 microns, boehmite powder that functions as a binder of the alpha alumina powders, and at least one burnout material having a particle size of 1-10 microns to provide a porous body having enhanced pore architecture in which extrusion cracks can be reduced. The presence of oxalic acid in such as precursor mixture can reduce and even eliminate NOx emission during a high temperature heat treatment process.

Abstract: A porous body with enhanced fluid transport properties and crush strength is provided. The porous body includes the porous body includes at least 80 percent alpha alumina and having a pore volume from 0.3 mL/g to 1.2 mL/g, a surface area from 0.3 m2/g to 3.0 m2/g, and a pore architecture that provides at least one of a tortuosity of 7 or less, a constriction of 4 or less and a permeability of 30 mdarcys or greater, wherein the porous body is a cylinder comprising at least two spaced apart holes that extend through an entire length of the cylinder. The porous body has a flat plate crush strength improved by more than 10% over a porous body cylinder having a same outer diameter and length, but having only a single hole.

Abstract: A precursor mixture for producing a porous body, wherein the precursor mixture comprises: (i) at least one milled alpha alumina powder having a particle size of 0.1 to 6 microns, (ii) non-silicate powder that functions as a binder of the alpha alumina powders, and (iii) at least one burnout material having a particle size of 1-10 microns and a decomposition temperature of less than 550° C., with the proviso that a burnout material having a decomposition temperature of 550° C. or greater is excluded from the precursor mixture.

Abstract: A porous body with enhanced fluid transport properties and crush strength is provided. The porous body includes the porous body includes at least 80 percent alpha alumina and having a pore volume from 0.3 mL/g to 1.2 mL/g, a surface area from 0.3 m2/g to 3.0 m2/g, and a pore architecture that provides at least one of a tortuosity of 7 or less, a constriction of 4 or less and a permeability of 30 mdarcys or greater, wherein the porous body is a cylinder comprising at least two spaced apart holes that extend through an entire length of the cylinder. The porous body has a flat plate crush strength improved by more than 10% over a porous body cylinder having a same outer diameter and length, but having only a single hole.

Abstract: Systems and methods for providing users with a real time or near-real time indications of media channels or programs that are currently receiving the most usage or consumption within a defined population of users are disclosed. In an embodiment, a method receives media usage data for currently airing media while the media is being aired and creates an ordered list of media channels or programs for presentation, based at least in part on the media usage data. The method then presents the ordered list of media channels or programs while the media is being aired. In an embodiment, a system further provides the ability to easily select and tune one of the indicated channels or programs in an interactive interface. In an embodiment, the selected media channels or programs are sold on demand or as part of a service upgrade if they are not included in a user's current subscription.

Abstract: Systems and methods for providing users with a real time or near-real time indications of media channels or programs that are currently receiving the most usage or consumption within a defined population of users are disclosed. In an embodiment, a method receives media usage data for currently airing media while the media is being aired and creates an ordered list of media channels or programs for presentation, based at least in part on the media usage data. The method then presents the ordered list of media channels or programs while the media is being aired. In an embodiment, a system further provides the ability to easily select and tune one of the indicated channels or programs in an interactive interface. In an embodiment, the selected media channels or programs are sold on demand or as part of a service upgrade if they are not included in a user's current subscription.

Abstract: Systems and methods for providing users with a real time or near-real time indications of media channels or programs that are currently receiving the most usage or consumption within a defined population of users are disclosed. In an embodiment, a method receives media usage data for currently airing media while the media is being aired and creates an ordered list of media channels or programs for presentation, based at least in part on the media usage data. The method then presents the ordered list of media channels or programs while the media is being aired. In an embodiment, a system further provides the ability to easily select and tune one of the indicated channels or programs in an interactive interface. In an embodiment, the selected media channels or programs are sold on demand or as part of a service upgrade if they are not included in a user's current subscription.

Abstract: Compositions and methods useful in the treatment of certain cancers. The methods include administering, to a patient receiving an antifolate anticancer agent, methoxyamine administered in an amount sufficient to enhance or increase the effect of the antifolate anticancer agent. In part, this application is based on the recognition that certain molecules that target abasic lesions or AP sites in DNA improve, augment, or potentiate the chemotherapeutic efficacy of certain anticancer agents.

Abstract: The invention relates to a simple and rapid method for the detection of cells and biomolecules by means of paramagnetic particles (beads) without separating the detected biomolecules or target cells from the beads before evaluating the specific bond.

Abstract: Compositions and methods useful in the treatment of certain cancers. The methods include administering, to a patient receiving an antifolate anticancer agent, methoxyamine administered in an amount sufficient to enhance or increase the effect of the antifolate anticancer agent. In part, this application is based on the recognition that certain molecules that target abasic lesions or AP sites in DNA improve, augment, or potentiate the chemotherapeutic efficacy of certain anticancer agents.