Patents by Inventor Jean Anne Chmielewski

Jean Anne Chmielewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210396743
    Abstract: A radical departure from the classical E1-E2-E3 three-enzyme mediated ubiquitination of eukaryotes, the bacterial enzymes of the SidE family of Legionella pneumophila effectors utilize NAD+ to ligate ubiquitin onto target substrate proteins achieved via a two-step mechanism involving (1) ADP-ribosylation of ubiquitin followed by (2) phosphotransfer to a target serine residue. Using fluorescent NAD+ analogues as well as synthetic substrate mimics, a continuous assay system enabling real-time monitoring of both steps of this mechanism is disclosed herein. These assays are amenable to biochemical studies and high-throughput screening of inhibitors of these effectors, and enable the discovery and characterization of putative enzymes similar to the SidE family in other organisms.
    Type: Application
    Filed: June 18, 2021
    Publication date: December 23, 2021
    Applicant: Purdue Research Foundation
    Inventors: Chittaranjan Das, Kedar Puvar, Aya M. Saleh, Ryan William Curtis, Tamara Lea Kinzer-Ursem, Jean Anne Chmielewski
  • Patent number: 10875895
    Abstract: The present disclosure relates to novel antibacterial cell-penetrating peptides and derivatives, and methods to make and use the novel antibacterial cell-penetrating peptides and derivatives. The novel antibacterial cell-penetrating peptides of the present invention with shorter linker between a pyrrolidine ring and a guanidine group provide unexpectedly higher potency against a broader scope of bacterial.
    Type: Grant
    Filed: November 13, 2019
    Date of Patent: December 29, 2020
    Assignee: Purdue Research Foundation
    Inventors: Jean Anne Chmielewski, Mohamed Seleem
  • Patent number: 10688192
    Abstract: The present disclosure relates to novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide, and methods to make and use the novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: June 23, 2020
    Assignee: Purdue Research Foundation
    Inventors: Jean Anne Chmielewski, Mohamed Seleem
  • Publication number: 20200172579
    Abstract: The present disclosure relates to novel antibacterial cell-penetrating peptides and derivatives, and methods to make and use the novel antibacterial cell-penetrating peptides and derivatives. The novel antibacterial cell-penetrating peptides of the present invention with shorter linker between a pyrrolidine ring and a guanidine group provide unexpectedly higher potency against a broader scope of bacterial.
    Type: Application
    Filed: November 13, 2019
    Publication date: June 4, 2020
    Applicant: Purdue Research Foundation
    Inventors: Jean Anne Chmielewski, Mohamed Seleem
  • Publication number: 20190175741
    Abstract: The present disclosure relates to novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide, and methods to make and use the novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide.
    Type: Application
    Filed: February 20, 2019
    Publication date: June 13, 2019
    Applicant: Purdue Research Foundation
    Inventors: Jean Anne Chmielewski, Mohamed Seleem
  • Patent number: 10265408
    Abstract: The present disclosure relates to novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide, and methods to make and use the novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: April 23, 2019
    Assignee: Purdue Research Foundation
    Inventors: Jean Anne Chmielewski, Mohamed Seleem
  • Patent number: 9533975
    Abstract: The present invention cationic amphiphilic polyproline helices (CAPHs) compounds having increased hydrophobicity and cellular internalization as antimicrobial agents. Antimicrobial compositions and methods of using the same are also provided.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: January 3, 2017
    Assignee: Purdue Research Foundation
    Inventor: Jean Anne Chmielewski
  • Publication number: 20150314009
    Abstract: The present invention cationic amphiphilic polyproline helices (CAPHs) compounds having increased hydrophobicity and cellular internalization as antimicrobial agents. Antimicrobial compositions and methods of using the same are also provided.
    Type: Application
    Filed: May 1, 2015
    Publication date: November 5, 2015
    Inventor: Jean Anne Chmielewski