Patents by Inventor Jean-Christophe Leroux
Jean-Christophe Leroux has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11999829Abstract: The present invention provides polymersomes comprising amphiphilic block-copolymers and their use to quantify ammonia in samples (e.g., body fluid samples). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid and at least one pH-sensitive dye. Compositions, strips and kits comprising the polymersomes are also provided along with methods of quantifying ammonia in a sample using the polymersomes, compositions and kit.Type: GrantFiled: March 20, 2023Date of Patent: June 4, 2024Assignee: ETH ZURICHInventors: Jean-Christophe Leroux, Simon Matoori, Olha Voznyuk Wuerthinger
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Patent number: 11896712Abstract: The present invention is directed to a liposome composition for use in the peritoneal dialysis of patients suffering from endogenous or exogenous toxicopathies, wherein the pH within the liposomes differs from the pH in the intraperitoneal cavity and wherein the pH within the liposome results in a liposome-encapsulated charged toxin. The invention also relates to a pharmaceutical composition comprising said liposomes. A further aspect of the present invention relates to a method of treating patients suffering from endogenous or exogenous toxicopathies, preferably selected from drug, metabolite, pesticide, insecticide, toxin, and chemical warfare toxicopathies, more preferably hyperammonemia, comprising the step of administering liposomes of the invention in a therapeutically effective amount into the peritoneal space of a patient in need thereof. Next to human, the present invention is particularly suitable to veterinary aspects.Type: GrantFiled: September 11, 2020Date of Patent: February 13, 2024Assignee: Versantis AGInventors: Jean-Christophe Leroux, Vincent Forster
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Publication number: 20240000811Abstract: The invention is related to an inositol polyphosphate oligo alkyl ether compound, or its pharmaceutically acceptable salt, for use in treatment or prevention of a disease associated with formation of calcium salt crystals.Type: ApplicationFiled: November 19, 2021Publication date: January 4, 2024Applicants: VIFOR (INTERNATIONAL) AG, ETH ZÜRICHInventors: Mattias Emanuel IVARSSON, Jean-Christophe LEROUX, Anna KLETZMAYR, Makoto KURO-O, Hirosaka HAYASHI
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Publication number: 20230338401Abstract: Provided herein is an inositol polyphosphate oligo alkyl ether compound, or its pharmaceutically acceptable salt, for use in treatment or prevention of a disease associated with formation of calcium salt crystals.Type: ApplicationFiled: June 12, 2023Publication date: October 26, 2023Applicants: ETH Zurich, Universitat BernInventors: Anna Kletzmayr, Makoto Kuro-o, Hirosaka Hayashi, Mattias Ivarsson, Jean-Christophe Leroux
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Publication number: 20230303778Abstract: The present invention provides polymersomes comprising amphiphilic block-copolymers and their use to quantify ammonia in samples (e.g., body fluid samples). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid and at least one pH-sensitive dye. Compositions, strips and kits comprising the polymersomes are also provided along with methods of quantifying ammonia in a sample using the polymersomes, compositions and kit.Type: ApplicationFiled: June 2, 2023Publication date: September 28, 2023Inventors: Jean-Christophe Leroux, Simon Matoori, Olha Voznyuk Wuerthinger
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Patent number: 11713376Abstract: The present invention provides polymersomes comprising amphiphilic block-copolymers and their use to quantify ammonia in samples (e.g., body fluid samples). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid and at least one pH-sensitive dye. Compositions, strips and kits comprising the polymersomes are also provided along with methods of quantifying ammonia in a sample using the polymersomes, compositions and kit.Type: GrantFiled: September 10, 2018Date of Patent: August 1, 2023Assignee: ETH ZURICHInventors: Jean-Christophe Leroux, Simon Matoori, Olha Voznyuk Wuerthinger
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Patent number: 11707470Abstract: The invention is related to an inositol polyphosphate oligo alkyl ether compound, or its pharmaceutically acceptable salt, for use in treatment or prevention of a disease associated with formation of calcium salt crystals.Type: GrantFiled: June 7, 2021Date of Patent: July 25, 2023Assignees: ETH Zurich, Universitat BernInventors: Anna Kletzmayr, Makoto Kuro-o, Hirosaka Hayashi, Mattias E. Ivarsson, Jean-Christophe Leroux
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Publication number: 20230220165Abstract: The present invention provides polymersomes comprising amphiphilic block-copolymers and their use to quantify ammonia in samples (e.g., body fluid samples). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid and at least one pH-sensitive dye. Compositions, strips and kits comprising the polymersomes are also provided along with methods of quantifying ammonia in a sample using the polymersomes, compositions and kit.Type: ApplicationFiled: March 20, 2023Publication date: July 13, 2023Inventors: Jean-Christophe Leroux, Simon Matoori, Olha Voznyuk Wuerthinger
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Publication number: 20220287971Abstract: A method for preparing transmembrane pH-gradient vesicles is provided. This method includes the following steps: a) preparing vesicles made from at least one matrix substance in an aqueous medium having an osmolarity of not more than 200 mOsm/l, wherein the matrix substance is chosen from the group consisting of amphiphilic lipids and amphiphilic block copolymers, b) transferring the vesicles into a basic or acidic buffer having an osmolarity being at least 200 mOsm/l higher than the osmolarity of the aqueous medium of step a) to apply an osmotic shock to the vesicles and to obtain buffer-filled vesicles and c) diluting a mixture of the aqueous medium and the basic or acidic buffer containing the buffer-filled vesicles by adding a neutralizing solution to obtain transmembrane pH-gradient vesicles suspended in a suspension buffer, wherein the suspension buffer differs from the basic or acidic buffer in pH value.Type: ApplicationFiled: June 2, 2022Publication date: September 15, 2022Inventors: Jean-Christophe Leroux, Vincent Forster, Valentina Agostoni
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Patent number: 11376218Abstract: The invention relates to a method for preparing transmembrane pH-gradient vesicles. This method includes the following steps: a) preparing vesicles made from at least one matrix substance in an aqueous medium having an osmolarity of not more than 200 mOsm/l. The matrix substance is chosen from the group consisting of amphiphilic lipids and amphiphilic block copolymers, b) transferring the vesicles into a basic or acidic buffer having an osmolarity being at least 200 mOsm/l higher than the osmolarity of the aqueous medium of step a) to apply an osmotic shock to the vesicles and to obtain buffer-filled vesicles and c) diluting a mixture of the aqueous medium and the basic or acidic buffer containing the buffer-filled vesicles by adding a neutralizing solution to obtain transmembrane pH-gradient vesicles suspended in a suspension buffer, which differs from the basic or acidic buffer in pH value.Type: GrantFiled: May 3, 2016Date of Patent: July 5, 2022Assignee: Versantis AGInventors: Jean-Christophe Leroux, Vincent Forster, Valentina Agostoni
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Publication number: 20210347793Abstract: The present invention relates to inositol derivatives comprising two or more cyclohexanolpentakisester moieties linked by a common central linker and their use in therapy or prevention of a condition related to pathological crystallization. The invention further relates to useful intermediates in the synthesis of the compound of the invention.Type: ApplicationFiled: September 18, 2019Publication date: November 11, 2021Applicant: INOSITEC AGInventors: Mattias Emanuel IVARSSON, Jean-Christophe LEROUX, Anna KLETZMAYR
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Publication number: 20210290643Abstract: The invention is related to an inositol polyphosphate oligo alkyl ether compound, or its pharmaceutically acceptable salt, for use in treatment or prevention of a disease associated with formation of calcium salt crystals.Type: ApplicationFiled: June 7, 2021Publication date: September 23, 2021Applicants: ETH Zurich, INOSITEC AGInventors: Anna Kletzmayr, Makoto Kuro-o, Hirosaka Hayashi, Mattias E. Ivarsson, Jean-Christophe Leroux
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Patent number: 11026891Abstract: The present invention provides polymersomes comprising non-biodegradable amphiphilic block-copolymers and their enteral (e.g., oral) or topical use in the treatment of an ammonia or ammonia methylated analog-associated disease or disorder or symptom thereof (e.g., hyperammonemia or trimethylaminuria). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid. It also provides a method of making the polymersome comprising mixing the copolymer-containing organic solvent phase with an aqueous phase containing the acid.Type: GrantFiled: August 15, 2017Date of Patent: June 8, 2021Assignee: Eth ZurichInventors: Jean-Christophe Leroux, Simon Matoori, Aaron Christoph Schmidt
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Patent number: 11028112Abstract: The present invention relates to inositol derivatives covalently modified with one, two or three solubility functions, particularly polyethylene glycol moieties, for use in therapy or prevention of conditions related to pathological calcium crystallization, such as cardiovascular calcifications, nephrocalcinosis, calcinosis cutis, chondrocalcinosis and kidney stones.Type: GrantFiled: April 20, 2020Date of Patent: June 8, 2021Assignees: ETH ZURICH, UNIVERSITAT BERNInventors: Mattias Ivarsson, Bastien Castagner, Jean-Christophe Leroux, Andreas Pasch
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Patent number: 11007282Abstract: This invention describes compositions comprising indocyanine green and poly(N-vinylpyrrolidone) and methods of making the same as well as applications thereof for diagnostic and therapeutic uses. One of those applications is the structural and functional assessment of the lymphatic system by fluorescence imaging.Type: GrantFiled: May 10, 2016Date of Patent: May 18, 2021Assignee: DICRONIS SAGLInventors: Jean-Christophe Leroux, Michael Detmar, Davide Brambilla, Steven Proulx
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Publication number: 20210128470Abstract: The present invention is directed to a liposome composition for use in the peritoneal dialysis of patients suffering from endogenous or exogenous toxicopathies, wherein the pH within the liposomes differs from the pH in the intraperitoneal cavity and wherein the pH within the liposome results in a liposome-encapsulated charged toxin. The invention also relates to a pharmaceutical composition comprising said liposomes. A further aspect of the present invention relates to a method of treating patients suffering from endogenous or exogenous toxicopathies, preferably selected from drug, metabolite, pesticide, insecticide, toxin, and chemical warfare toxicopathies, more preferably hyperammonemia, comprising the step of administering liposomes of the invention in a therapeutically effective amount into the peritoneal space of a patient in need thereof. Next to human, the present invention is particularly suitable to veterinary aspects.Type: ApplicationFiled: September 11, 2020Publication date: May 6, 2021Inventors: Jean-Christophe Leroux, Vincent Forster
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Publication number: 20200283583Abstract: The present invention provides polymersomes comprising amphiphilic block-copolymers and their use to quantify ammonia in samples (e.g., body fluid samples). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid and at least one pH-sensitive dye. Compositions, strips and kits comprising the polymersomes are also provided along with methods of quantifying ammonia in a sample using the polymersomes, compositions and kit.Type: ApplicationFiled: September 10, 2018Publication date: September 10, 2020Inventors: Jean-Christophe Leroux, Simon Matoori, Olha Voznyuk Wuerthinger
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Publication number: 20200247837Abstract: The present invention relates to inositol derivatives covalently modified with one, two or three solubility functions, particularly polyethylene glycol moieties, for use in therapy or prevention of conditions related to pathological calcium crystallization, such as cardiovascular calcifications, nephrocalcinosis, calcinosis cutis, chondrocalcinosis and kidney stones.Type: ApplicationFiled: April 20, 2020Publication date: August 6, 2020Applicants: ETH Zurich, UNIVERSITAT BERNInventors: Mattias IVARSSON, Bastien CASTAGNER, Jean-Christophe LEROUX, Andreas PASCH
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Patent number: 10624909Abstract: The present invention relates to inositol derivatives covalently modified with one, two or three solubility functions, particularly polyethylene glycol moieties, for use in therapy or prevention of conditions related to pathological calcium crystallization, such as cardiovascular calcifications, nephrocalcinosis, calcinosis cutis, chondrocalcinosis and kidney stones.Type: GrantFiled: December 12, 2016Date of Patent: April 21, 2020Assignees: ETH ZURICH, UNIVERSITAT BERNInventors: Mattias Ivarsson, Bastien Castagner, Jean-Christophe Leroux, Andreas Pasch
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Patent number: 10596114Abstract: The present invention is directed to a liposome composition for use in the peritoneal dialysis of patients suffering from endogenous or exogenous toxicopathies, wherein the pH within the liposomes differs from the pH in the intraperitoneal cavity and wherein the pH within the liposome results in a liposome-encapsulated charged toxin. The invention also relates to a pharmaceutical composition comprising said liposomes. A further aspect of the present invention relates to a method of treating patients suffering from endogenous or exogenous toxicopathies, preferably selected from drug, metabolite, pesticide, insecticide, toxin, and chemical warfare toxicopathies, more preferably hyperammonemia, comprising the step of administering liposomes of the invention in a therapeutically effective amount into the peritoneal space of a patient in need thereof. Next to human, the present invention is particularly suitable to veterinary aspects.Type: GrantFiled: August 6, 2013Date of Patent: March 24, 2020Assignee: ETH ZURICHInventors: Jean-Christophe Leroux, Vincent Forster