Patents by Inventor Jean-Claude Jacquesy
Jean-Claude Jacquesy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7291627Abstract: The invention concerns dihydroimidazo[5,1-a]-?-carboline compounds of general formula (I) wherein in particular, R1, R2, R3, R4, R6 and R7, identical or different, independently of one another, present a hydrogen, halogen atom, an alkyl, hydroxyl, alkoxy, trihalogenoalkyl, alkylamino, dialkylamino, aryl, arylalkyl, carboxy, alkylcarbonyloxy, acyl, aryloxy or arylalkoxy group; R5 represents a hydrogen atom, an alkyl or arylalkyl group; and their isomers as well as their addition salts to a pharmaceutically acceptable acid. The inventive compounds are for use in medicine, in particular as hypnotics.Type: GrantFiled: May 16, 2002Date of Patent: November 6, 2007Assignee: MACEFInventors: Jean-Bernard Fourtillan, Marianne Fourtillan, Omar Karam, Fabien Zunino, Jean-Claude Jacquesy, Jean-Pierre Tafani
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Publication number: 20060089372Abstract: The invention concerns dihydroimi-dazo[5,1-a]-?-carboline compounds of general formula (1), wherein in particular, R1, R2, R2, Ra, R6 and K7, identical or different, independently of one another, represent a hydrogen, halogen atom, an alkyl, hydroxy, alkoxy, trihalogenoalkyl, alkylamino, dialkylamino, aryl, arylalkyl, carboxy, alkylcarbonyloxy, acyl, aryloxy or arylalkoxy group; R3 represents a hydrogen atom, an alkyl or arylalkoxy group; and their isomers as well as their addition salts to a pharmaceutically acceptable acid. The inventive compounds arm for use as medicine, in particular as hypnotic.Type: ApplicationFiled: May 16, 2002Publication date: April 27, 2006Inventors: Jean-Bernard Fourtillan, Marianne Fourtillan, Omar Karam, Fabien Zunino, Jean-Claude Jacquesy, Jean-Pierre Tafani
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Patent number: 6335346Abstract: The invention relates to pyrrolo[3,4-b]quinoline derivatives of general formula (I) wherein X represents an oxygen atom or a sulphur atom. Said derivatives have a hypnotic or sedative effect.Type: GrantFiled: December 26, 2000Date of Patent: January 1, 2002Assignees: MACEF, Laboratoires Besins IscovescoInventors: Jean-Bernard Fourtillan, Marianne Fourtillan, Jean-Claude Jacquesy, Omar Karam, Fabien Zunino, Marie-Paule Jouannetaud
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Patent number: 6146658Abstract: Glycosyl-spacer-drugs compounds (prodrugs), their preparation and their use as pharmaceuticals are described.Type: GrantFiled: May 20, 1997Date of Patent: November 14, 2000Assignee: Hoechst AktiengesellschaftInventors: Klaus Bosslet, Jorg Czech, Dieter Hoffmann, Cenek Kolar, Fran.cedilla.ois Tillequin, Jean-Claude Florent, Michel Azoulay, Claude Monneret, Jean-Claude Jacquesy, Jean-Pierre Gesson, Michel Koch
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Patent number: 6140372Abstract: The invention relates to derivatives of general formula I ##STR1## as defined in the description. The invention also relates to a process for their preparation and to their therapeutic use, in particular for the treatment of complaints associated with melatonin disorders, and pharmaceutical and cosmetic compositions comprising them.Type: GrantFiled: April 16, 1999Date of Patent: October 31, 2000Assignee: Cemaf and Laboratories Besins Isovesco S.A.Inventors: Jean-Bernard Fourtillan, Marianne Fourtillan, Jean-Claude Jacquesy, Marie-Paule Jouannetaud, Bruno Violeau, Omar Karam
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Patent number: 6066663Abstract: The invention relates to derivatives of general formula I ##STR1## The invention also relates to pharmaceutical and cosmetic compositions comprising derivatives of general formula I.Type: GrantFiled: August 11, 1998Date of Patent: May 23, 2000Assignees: CEMAF, Laboratories Besins-Iscovesco S.A.Inventors: Jean-Bernard Fourtillan, Marianne Fourtillan, Jean-Claude Jacquesy, Marie-Paule Jouannetaud, Bruno Violeau, Omar Karam
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Patent number: 6048868Abstract: The present invention provides .beta.-carboline derivatives useful as components of cosmetic, medicinal, and pharmaceutical compositions. The medicinal and pharmaceutical compositions can be used to induce hypnotic activity in a subject. Methods of producing the .beta.-carboline derivatives are provided as well.Type: GrantFiled: March 17, 1998Date of Patent: April 11, 2000Assignees: Cemaf, Laboratories Besins IscovescoInventors: J-Bernard Fourtillan, Marianne Fourtillan, Jean-Claude Jacquesy, Marie-Paule Jouannetaud, Bruno Violeau, Omar Karam
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Patent number: 6004991Abstract: The invention relates to derivatives of general formula I ##STR1## as defined in the description. The invention also relates to a process for their preparation and to their therapeutic use, in particular or the treatment of complaints associated with melatonin disorders, and pharmaceutical and cosmetic compositions comprising them.Type: GrantFiled: March 27, 1998Date of Patent: December 21, 1999Assignee: CEMAF and Laboratoires Besins Iscovesco S.A.Inventors: Jean-Bernard Fourtillan, Marianne Fourtillan, Jean-Claude Jacquesy, Marie-Paule Jouannetaud, Bruno Violeau, Omar Karam
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Patent number: 5955100Abstract: Glycosyl-spacer-drugs compounds (prodrugs), their preparation and their use as pharmaceuticals are described.Type: GrantFiled: May 24, 1995Date of Patent: September 21, 1999Assignees: Behringwerke Aktiengesellschaft, Laboratories Hoechst S/AInventors: Klaus Bosslet, Jorg Czech, Dieter Hoffmann, Cenek Kolar, Fran.cedilla.ois Tillequin, Jean-Claude Florent, Michel Azoulay, Claude Monneret, Jean-Claude Jacquesy, Jean-Pierre Gesson, Michel Koch
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Patent number: 5877158Abstract: Substrate-spacer-prodrug compounds (pro-prodrugs) suited for site specific delivery of drugs, a process of preparing them and their use are described.Type: GrantFiled: September 20, 1994Date of Patent: March 2, 1999Assignees: Behringwerke Aktiengesellschaft, Laboratoires Hoechst S/AInventors: Klaus Bosslet, Jorg Czech, Dieter Hoffmann, Fran.cedilla.ois Tillequin, Jean-Claude Florent, Michel Azoulay, Claude Monneret, Jean-Claude Jacquesy, Jean-Pierre Gesson, Michel Koch
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Patent number: 5763471Abstract: The present invention relates to spiro?3H-indole-3(2H),3'-pyrrolidine! derivatives of general formula I ##STR1## as defined in the description. The invention also relates to a process for their preparation and to their therapeutic use, in particular for the treatment of complaints associated with melatonin disorders, and to the pharmaceutical and cosmetic compositions comprising them.Type: GrantFiled: December 11, 1996Date of Patent: June 9, 1998Assignees: CEMAF, Laboratories Besins IscovescoInventors: Jean-Bernard Fourtillan, Marianne Fourtillan, Jean-Claude Jacquesy, Marie-Paule Jouannetaud, Bruno Violeau, Omar Karam
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Patent number: 5621002Abstract: Enzymatically clearable prodrugs with reduced Michaelis-Menten constant (Km) are described.Type: GrantFiled: September 9, 1994Date of Patent: April 15, 1997Assignees: Behringwerke Aktiengesellschaft, Laboratoires Hoechst S/AInventors: Klaus Bosslet, J org Czech, Dieter Hoffmann, Andrea Vasella, Roland Hoos, Fran.cedilla.ois Tillequin, Jean-Claude Florent, Michel Azoulay, Claude Monneret, Jean-Claude Jacquesy, Jean-Pierre Gesson, Michel Koch
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Patent number: 5620985Abstract: Novel fluorinated derivatives of the vinblastine and vinorelbine family of general formula (1), ##STR1## wherein the symbols have the meanings indicated in the Specification and Claims, and the therapeutically-acceptable salts of these molecules, as well as pharmaceutical compositions thereof. The invention also concerns the application of said compounds in the treatment of a cancer pathology and their methods of preparation.Type: GrantFiled: January 19, 1996Date of Patent: April 15, 1997Assignee: Pierre Fabre MedicamentInventors: Jean-Claude Jacquesy, Jacques Fahy, Christian Berrier, Dennis Bigg, Marie-Paule Jouannetaud, Fabien Zunino, Anna Kruczynski, Robert Kiss
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Patent number: 5561119Abstract: Glycosylated prodrugs, a preparation method therefor, and their use with tumor-specific immunoenzymatic conjugates for the treatment of cancer, are described. These anthracycline prodrugs have formula (I).Type: GrantFiled: May 27, 1994Date of Patent: October 1, 1996Assignees: Laboratoires Hoechst, Behringwerke A.G.Inventors: Jean-Claude Jacquesy, Jean-Pierre Gesson, Claude Monneret, Martine Mondon, Brigitte Renoux, Jean-Claude Florent, Michel Koch, Fran.cedilla.ois Tillequin, Hans H. Sedlacek, Manfred Gerken, Cenek Kolar, Gilbert Gaudel, Klaus Bosslet, J org Czech, Dieter Hoffman, Gerhard Seemann, Hans-Ulrich Schorlemmer, Gerhard Dickneite
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Patent number: 4789665Abstract: The present invention relates to new anthracyclines corresponding to the general formula I below: ##STR1## in which R' and R", which may be identical or different, denote a hydrogen atom (and in this case R' is different from R") or the group --(CH.sub.2).sub.n --R.sub.1 --(CH.sub.2).sub.m --R.sub.2 where n is between 1 and 6,m is between 0 and 4 (with the proviso, of course, that if m=0, R.sub.2 is nonexistent)R.sub.1 denotes one of the following groups: ##STR2## (in this case, m=0) ##STR3## (in this case m=0) where R.sub.3 and R.sub.4, which may be identical or different, denote a hydrogen atom or a substituted or unsubstituted alkyl group)--C.tbd.N (in this case m=0)--S----O--(with the proviso that m is other than 0) ##STR4## (m=0 and R.sub.3 R.sub.4 have the same meaning as above) and R.sub.2 denotes (in the case where m is other than 0) a hydrogen atom or alkyl or alkoxy groups or ##STR5## (R.sub.3 and R.sub.4 having the same meaning as above).Type: GrantFiled: December 15, 1986Date of Patent: December 6, 1988Assignees: Laboratoires Hoechst S. A., Behringwerke AktiengesellschaftInventors: Jean-Pierre Gesson, Martine Mondon, Jean-Claude Jacquesy, Hans P. Kraemer
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Patent number: 4731468Abstract: The present invention relates to new aglycons which correspond to the general formula: ##STR1## in which: R.sub.1, R.sub.2, R.sub.3 and R.sub.5, which can be identical or different, represent a hydrogen atom or a group OH, OMetal or OR.sub.4, R.sub.4 being a substituted or unsubstituted C.sub.1 to C.sub.6 alkyl group,R represents a hydrogen atom or a group COCH.sub.2 R', R' being hydrogen or an alkyl, hydroxyl, alkoxy or aryl group,R.sub.6 and R.sub.7, which are always different, represent either a hydrogen atom or an OH group, andR.sub.8 represents a hydrogen atom or the group CH.sub.3 CO--.Application to the preparation of antibiotics and antitumoral agents.Type: GrantFiled: August 29, 1984Date of Patent: March 15, 1988Assignee: Laboratoires Hoechst S.A.Inventors: Jean-Pierre Gesson, Martine Mondon, Abdallah A. Abdallah, Jean-Claude Jacquesy, Patricia Petit nee Monpontet
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Patent number: 4588841Abstract: Process for the preparation of aminophenols with an increased proportion of the meta isomer comprising reacting hydrogen peroxide in a superacid liquid medium with anilines, N-alkylaniline, or N,N-dialkylanilines for a time and a temperature, ranging from about -50.degree. C. to 0.degree. C., sufficient to form the aminophenols.Type: GrantFiled: June 13, 1984Date of Patent: May 13, 1986Assignee: AtochemInventors: Guy Morellet, Jean-Claude Jacquesy, Marie-Paule Jouannetaud
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Patent number: 4453024Abstract: Process for hydroxylating alkylphenols in which the carbon atoms of the alkyl group bonded to the aromatic nucleus has at least one hydrogen atom bonded thereto and the phenolic ethers thereof, at the meta position relative to the phenol or ether function, by reacting the phenol compound with an aqueous hydrogen peroxide solution in the presence of a liquid superacid at low temperature.Type: GrantFiled: September 30, 1982Date of Patent: June 5, 1984Assignee: PCUK Produits Chimiques Ugine KuhlmannInventors: Marie-Paule Jouannetaud, Jean-Pierre Gesson, Jean-Claude Jacquesy