Abstract: The invention relates to a method for providing organic, semi-organic, mineral, inorganic and hybrid thin layers and thin layers containing nanoparticles, by simultaneous or alternate spraying of solutions of reactive partners (that is polymer/polymer interacting by hydrogen bonding, polyelectrolyte/small oligo-ion, inorganic compounds, etc.) on the surface of a solid substrate.

Abstract: The invention relates to methods for preparing crosslinked polyelectrolytes, in particular crosslinked polyelectrolytes multilayer films. The invention also relates to a method of coating a surface, and the obtained coated article.

Abstract: The novel biomaterial fillers containing cross-linked sodium alginate and the method for manufacturing same are used in the medical field and are intended for filling tissue lesions having a layered structure of varying compositions, such as cartilage, skin or the epithelium. These novel biomaterials have the special feature of being multiphasic, composite and functionalized, for medical use and, in particular, for treating tissue lesions having a layered structure of varying compositions. The biomaterials are particularly suitable for treating focal lesions of the articular cartilage.

Abstract: The invention relates to a method for providing organic, semi-organic, mineral, inorganic and hybrid thin layers and thin layers containing nanoparticles, by simultaneous or alternate spraying of solutions of reactive partners (that is polymer/polymer interacting by hydrogen bonding, polyelectrolyte/small oligo-ion, inorganic compounds, etc.) on the surface of a solid substrate.

Abstract: The invention relates to the use of a unit including a substrate and polyelectrolyte multilayer films deposited thereon in order to: carry out a method involving the proliferation of initial stem or differentiated cells that are brought into contact with the unit; and cover the unit with confluent viable adherent cells resulting from the proliferation of the initial cells, the cover being obtained at the end of a period of no more than one month, such as 14 days, 11 days or, in particular, 7 days, after the initial cells are brought into contact with the unit.

Abstract: The invention concerns a mechanically responsive supported polyelectrolyte multilayer film, comprising:—an elastic substrate, on which are alternately coated:—at least one exponentially growing film; and—at least one mechanically responsive barrier film. It further concerns a process for its preparation and the use of such films notably for mechanically responsive mixing or delivery of active substances. It further concerns dosage forms of a drug, biosensors and implants comprising such films.

Abstract: The invention concerns a method for constructing a functional living biomaterial, characterized in that it consists in assembling layer by layer (3D) a matrix and 2D layers of functional living cells by controlling their interactions and 3D structuring based on the desired organization and final shape of the biomaterial, wherein each layer has its own pattern adapted to the neighbouring layers and on the functionality of whole synthetic biomaterials. The invention is useful in the field of biomedicine and nanobiotechnology.

Abstract: The invention relates to a material providing support and/or replacement of living tissues and the use thereof for manufacturing prostheses. The material according to the invention comprises microparticles of a biomaterial coated with polyelectrolyte multilayers containing one or more biologically active products.

Abstract: The invention relates to polyelectrolyte multilayer films presenting a tunable biological activity and methods for preparing the same. The invention further relates to surfaces presenting such films and uses thereof, such as for the controlled delivery of biologically active agents.

Abstract: The invention relates to methods for preparing crosslinked polyelectrolytes, in particular crosslinked polyelectrolytes multilayer films. The invention also relates to a method of coating a surface, and the obtained coated article.

Abstract: The invention concerns biomaterials comprising a core coated with alternating layers of polyelectrolytes with opposite charges, characterised in that they include one or several biologically active molecules, with molecular weight less than about 10000 Da, said molecules being fixed to one or several layers of polyelectrolytes.