Abstract: The present invention provides novel hypoosmotic saline compositions and their use as medicines for the prevention of the release of chemical mediators responsible for triggering phenomena causing inflammation of mucous membranes, and for the dissolution of cerumen plugs located in the external auditory meatus.

Abstract: The present invention relates to a method for making flours having a high food safety level comprising the grinding of grains previously cleaned and moistened, characterized in that, prior to or simultaneously with said grinding, said grains are brought into contact with ozone produced from a carrier gas, preferably in a quantity of between 0.5 and 20 expressed in grams of ozone per kilo of grains.

Abstract: The present invention relates to compositions and methods for treating humans and warm-blood animals suffering from cancer. More particularly, a therapeutical treatment in which a monoclonal antibody is administered with either ?-(1,3)-glucan like laminarin or a oligo-?-(1,3)-glucan and a pharmaceutically acceptable carrier, to patients suffering from cancer are described.

Abstract: A therapeutical method comprising administration of a composition comprising an amount of oligo-?-(1,3)-glucan and a pharmaceutically acceptable carrier, to a human being or to a warm-blood animal suffering from a disease selected from the group consisting in a tumor, a cancer, a viral disease, a bacterial disease, a fungal disease, a disease of the immune system, an auto-immune disease or a disease related to a deficiency of immunostimulation, wherein the amount of oligo-?-(1,3)-glucan is effective to treat the disease.

Abstract: Chemotherapeutic antineoplastic method comprising administration of an effective amount of an antineoplastic agent in conjunction with an effective amount of a ?-1,3 glucan.

Abstract: Treatment for preventing and limiting the release of the chemical mediators which are responsible of the starting of cutaneous inflammatory phenomena comprising administration to a patient of hypoosmotic saline solutions.

Abstract: The present invention relates to genes which code for glycosyl hydrolases having an HCA score with the iota-carrageenase of Alteromonas fortis which is greater than or equal to 65% over the domain extending between amino acids 164 and 311 of the protein sequence SEQ ID No. 2 of said iota-carrageenase, and to genes which code for glycosyl hydrolases having an HCA score with the kappa-carrageenase of Alteromonas carrageenovora which is greater than or equal to 75% over the domain extending between amino acids 117 and 262 of the protein sequence SEQ ID No. 6 of said kappa-carrageenase.

Abstract: The invention relates to a method for preparing free polyunsaturated fatty acids and their oxidation metabolites, wherein, successively,

Abstract: A medicinal product, which comprises, as active substance, an effective amount of at least one of the metabolites of the group comprising 12-HETE and 11,12-EET.

Abstract: The invention concerns the use for preparing a medicine for treating inflammatory diseases induced by non-specific inflammatory responses, that is antigen-independent, of a laminarin sulphate, having a degree of sulphation not less than 1.9 and preferably between 2 and 2.5 degree of polymerization identical to that of the natural molecule, that is 20 to 30.

Abstract: The invention concerns a medicine comprising, as active principle, an efficient quantity of at least an oligosaccharide substance capable of modulating apoptosis dysfunction which is capable of modifying apoptosis dysfunctions said substance being selected from the group consisting of oligosaccharides which are derived, by enzymatic or chemical process, from the polymers of the group comprising (1→3)-&bgr;-glucans which optionally comprise (1→6)-&bgr;-branching, and oligosaccharides which are derived, by enzymatic or chemical process, from sulfated galactans, it also concerns a method for treating apoptosis dysfunction.

Abstract: The invention relates to a method for the stimulation of the reactions of natural defence of agronomically useful and of decorative plants, characterized by the fact that there is applied on the plants to be treated an aqueous composition comprising an efficient concentration in sulfate of &bgr; 1-3 glucan and more particularly a concentration of at least 1 mg/l, preferably of at least 5 mg/l, and still more preferably of at least 10 mg/l in laminarin sulfate, whose degree of sulfatation is higher than or equal to 1.9, preferably from 2 to 2.5, the said composition being applied to the culture or crop to be treated in an amount sufficient to provide per hectare an efficient amount of sulfate of &bgr; 1-3 glucan, and in the case of laminarin sulfate in an amount sufficient to provide from 0.4 to 4 g of laminarin sulfate per hectare.

Abstract: The invention concerns the use of iso-osmotic saline solutions, in particular obtained from sea water, to obtain a medicine for cerumenolytic treatment.

Abstract: Therapeutical method comprising administration to a patient of an effective amount of especially soluble laminarin for the treatment of tumors and more generally of cancers of the group comprising breast cancer, lung cancer, oesophagus cancer, stomach cancer, intestine and colon cancers, and for the treatment of viral, bacterial and fungal diseases as well as diseases related to immunostimulant deficiencies of human beings and warm-blood animals.

Abstract: The invention concerns a method for preparing Laminaribiose comprising a step for glycoside binding between a donor and an acceptor of glycosyl. The invention is characterized in that the glycosyl donor is in pyranose form and corresponds to formula (II); the glycosyl acceptor is in furanose form and corresponds to formula (III); said binding step is performed in solution in an anhydrous organic solvent, at a temperature ranging between −80° C. and 40° C., for a time interval ranging between 1 minute and 8 hours, in the presence of a suitable promoter.

Abstract: The invention concerns the use of at least a polysaccharide substance having at least five saccharide units and comprising at least some single-unit motifs thereof, at least a substituent bearing at least a negative charge selected among the group comprising in particular the sulphate, acetate, phosphate, phosphonate groups, for preparing a medicine for activating apoptosis by increasing the number of apoptosis receptors at the cell surface, said receptors being those of the group comprising Fas, TNF, TRAIL, CD40, preferably Fas and TNF, receptors.

Abstract: The invention concerns the use for treating and cleaning the eye and is appendages of aqueous ionic solutions obtained from sea water whereof the ionic compositions is qualitatively that of sea water and quantitatively such that their pH ranges between 4 and 9, preferably between 7 and 8 and their osmolality ranges between 150 and 700, preferably between 250 and 350 mOsm/kg.

Abstract: Therapeutical method comprising administration to a patient of an effective amount of especially soluble laminarin for the treatment of tumors and more generally of cancers of the group comprising breast cancer, lung cancer, oesophagus cancer, stomach cancer, intestine and colon cancers, and for the treatment of viral, bacterial and fungal diseases as well as diseases related to immunostimulant deficiencies of human beings and warm-blood animals.

Abstract: The invention concerns a novel method for preparing by chemical process functionalised &bgr;-(1,3)-glucan derivatives, enabling to obtain free oligosaccharides or comprising specific groups such as, for instance, sulphate, phosphate, methyl, in predetermined positions. Said method consists in reacting a glycosyl donor of formula (Ia) or (Ib) with a glycosyl scavenger of formula (II), as defined in the claims. The invention is useful for preparing biologically active principles for use in the agricultural, cosmetic or pharmaceutical field.

Abstract: The present invention relates to a method for making flours having a high food safety level comprising the grinding of grains previously cleaned and moistened, characterized in that, prior to or simultaneously with said grinding, said grains are brought into contact with ozone produced from a carrier gas, preferably in a quantity of between 0.5 and 20 expressed in grams of ozone per kilo of grains.