Abstract: Compounds corresponding to formula I: which act as vanilloid receptor ligands, pharmaceutical composition s containing such compounds, a method for producing the compounds, and the use of such compounds to treat pain and various other conditions.

Abstract: Vanilloid receptor ligand compounds corresponding to formula I: a process for producing such compounds, pharmaceutical compositions containing them, and the use of such compounds to treat pain and various other vanilloid receptor mediated conditions.

Abstract: The invention relates to the use of compounds which exhibit an affinity for the ?-opioid receptor of at least 100 nM (Ki value, human) and an affinity for the ORL-1 receptor, wherein the ratio between the affinities ORL1/? defined as 1/[Ki(ORL1)/Ki(?)] is from 0.1 to 30, for the treatment of pain.

Abstract: This invention relates to a hydroxy-tetrahydro-naphthalene or an urea derivative formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations, wherein A represents formula (II) or (III) wherein # represents the connection position to the molecule and Q1a, Q2a, Q3a and Q4a are defined, and E represents formula (IV) or (V) wherein # represents the connection position to the molecule and Q1b, Q2b, Q3b, Q4b, Q5b, R1b, na, ma, Xa and Ra are defined.

Abstract: The present invention relates to novel vanilloid receptor ligands, to a process for the production thereof, to pharmaceutical preparations containing these compounds and to the use of these compounds for the production of pharmaceutical preparations.

Abstract: An information service provides search and notifications to inform when certain people (e.g., friends, family, business contacts, etc.) are nearby so as to facilitate communications with those people. Users may define lists of people whose locations may be tracked by positioning equipment based on personal communications/computing devices carried by the people. The information service processes this people and place data to identify those of the listed people that are in the user's vicinity, and provide notifications and user-initiated search results informing the user such as via the user's personal communications/computing device.

Abstract: For distributed querying of confidential information, a querying data structure is constructed from the confidential information on the computer at which the confidential information resides. The querying data structure opaquely encapsulates queries on the confidential information as a set of query hashes and answer pairs. The querying data structure is distributed to other computers where the distributed query processing is to be performed. The query is performed on such other computers by hashing the query terms, using the resulting query hash as a look up index to the associated answer in the querying data structure, and acting on the answer. A strictly one-way hash is used to prevent recovery of the original inputs to the query hashes in the query data structure by reverse hash.

Abstract: The invention provides methods for autonomous detection and adaptation with respect to an interfering signal on a frequency channel to assist a wireless device on a wireless network in choosing an appropriate frequency channel. According to embodiments, a method determines an appropriate channel by first detecting whether there is an interfering signal on a frequency channel over the wireless network, then retrieving data from the interferomg signal to retrieve protocol identification information. Prior to determining whether to transmit over the frequency channel, the method calls for determining whether the identified protocol of the interfering signal is a predetermined protocol.