Patents by Inventor Jean Lafay

Jean Lafay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for isomerizing fused bicyclic structures and preparation of vitamin D analogs comprising the same
    Patent number: 9315455
    Abstract: The present invention concerns a process of isomerizing trans fused bicyclic derivatives into cis fused bicyclic derivatives and the preparation of vitamin D or analogs thereof comprising said isomerization step.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: April 19, 2016
    Assignee: HYBRIGENICS SA
    Inventors: Jean-Luc Moutou, Florent Mouton, Gilles Pellegrino, Jean Lafay
  • Process for introducing a double bond into position 15, 16 of a steroid
    Patent number: 9012667
    Abstract: The invention relates to a process for the preparation of a compound of formula (I): wherein R1 and R2 are as defined in the description, by reaction of a compound of formula (II) with a base. Compound (I) is an intermediate useful in the preparation of gestodene.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: April 21, 2015
    Assignee: Laboratoire Theramex
    Inventors: Jean-Luc Moutou, Florent Mouton, Gilles Pellegrino, Jean-Marc Dillenschneider, Jean Lafay
  • 1-N-phenyl-amino-1h-imidazole derivatives and pharmaceutical compositions containing them
    Patent number: 8476455
    Abstract: The invention relates to the compounds of formula (I): in which R1, R2, R3, R4, Q and Z are as defined in the specification. The invention also relates to the pharmaceutical compositions containing these compounds.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: July 2, 2013
    Assignee: Laboratoire Theramex
    Inventors: Jean Lafay, Benoit Rondot, Paule Bonnet, Thierry Clerc, Jacqueline Shields, Igor Duc, Eric Duranti, Francois Puccio, Christian Blot, Philippe Maillos
  • PROCESS FOR INTRODUCING A DOUBLE BOND INTO POSITION 15, 16 OF A STEROID
    Publication number: 20130137885
    Abstract: The invention relates to a process for the preparation of a compound of formula wherein R1 and R2 are as defined in the description, by reaction of a compound of formula (II) with a base. Compound (I) is an intermediate useful in the preparation of gestodene.
    Type: Application
    Filed: February 8, 2011
    Publication date: May 30, 2013
    Applicant: LABORATOIRE THERAMEX
    Inventors: Jean-Luc Moutou, Florent Mouton, Gilles Pellegrino, Jean-Marc Dillenschneider, Jean Lafay
  • Indazoles, benzisoxazoles and benzisothiazoles and their use as estrogenic agents
    Patent number: 8173679
    Abstract: The present invention relates to compounds of formula (I): in which R1, R2, R3, X, Y and A are as defined in the specification. The compounds are modulators of the estrogen receptors.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: May 8, 2012
    Assignee: Laboratoire Thermamex
    Inventors: Benoit Rondot, Jean Lafay, Paule Bonnet, Thierry Clerc, Igor Duc, Eric Duranti, Francois Puccio, Jacqueline Shields, Christian Blot, Philippe Maillos
  • INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AND THEIR USE AS ESTROGENIC AGENTS
    Publication number: 20110237624
    Abstract: The present invention relates to compounds of formula (I): in which R1, R2, R3, X, Y and A are as defined in the specification. The compounds are modulators of the estrogen receptors.
    Type: Application
    Filed: June 3, 2011
    Publication date: September 29, 2011
    Applicant: LABORATOIRE THERAMEX
    Inventors: Benoit RONDOT, Jean LAFAY, Paule BONNET, Thierry CLERC, Igor DUC, Eric DURANTI, François PUCCIO, Jacqueline SHIELDS, Christian BLOT, Philippe MAILLOS
  • New Process for Isomerizing Fused Bicyclic Structures and Preparation of Vitamin D Analogs Comprising the Same
    Publication number: 20110184198
    Abstract: The present invention concerns a process of isomerizing trans fused bicyclic derivatives into cis fused bicyclic derivatives and the preparation of vitamin D or analogs thereof comprising said isomerisation step.
    Type: Application
    Filed: January 24, 2011
    Publication date: July 28, 2011
    Inventors: Jean-Luc MOUTOU, Florent Mouton, Gilles Pellegrino, Jean Lafay
  • Indazoles, benzisoxazoles and benzisothiazoles and their use as estrogenic agents
    Patent number: 7977364
    Abstract: The present invention relates to compounds of formula (I): in which R1, R2, R3, X, Y and A are as defined in the specification. The compounds are modulators of the estrogen receptors.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: July 12, 2011
    Assignee: Laboratoire Thermamex
    Inventors: Benoit Rondot, Jean Lafay, Paule Bonnet, Thierry Clerc, Igor Duc, Eric Duranti, Francois Puccio, Jacqueline Shields, Christian Blot, Philippe Maillos
  • SULFAMATOBENZOTHIOPHENE DERIVATIVES
    Publication number: 20100168217
    Abstract: The invention relates to novel compound of the general formula (I), in which R has the meanings indicated in claim 1, to the preparation thereof and to the use thereof as medicaments. The compounds (I) are inhibitors of steroid sulfatase and are used for the treatment of cancer.
    Type: Application
    Filed: November 13, 2007
    Publication date: July 1, 2010
    Applicant: MERCK PATENT GMBH
    Inventors: Wolfgang Staehle, David Bruge, Gerald Scholz, Benoit Rondot, Jean Lafay
  • SULFAMATOBENZOTHIOPHENE DERIVATIVES
    Publication number: 20090286863
    Abstract: The invention relates to novel compound of the general formula (I), in which R has the meanings indicated in Claim 1, to the preparation thereof and to the use thereof as medicaments. The compounds (I) are inhibitors of steroid sulfatase and are used for the treatment of cancer.
    Type: Application
    Filed: June 5, 2007
    Publication date: November 19, 2009
    Inventors: David Bruge, Wolfgang Staehle, Gerald Scholz, Benoit Rondot, Jean Lafay
  • Indazoles, benzisoxazoles and benzisothiazoles and their use as estrogenic agents
    Publication number: 20090023779
    Abstract: The present invention relates to compounds of formula (I): in which R1, R2, R3, X, Y and A are as defined in the specification. The compounds are modulators of the estrogen receptors.
    Type: Application
    Filed: October 14, 2005
    Publication date: January 22, 2009
    Applicant: Laboratoire Theramex
    Inventors: Benoit Rondot, Jean Lafay, Paule Bonnet, Thierry Clerc, Igor Duc, Eric Duranti, Francois Puccio, Jacqueline Shields, Christian Blot, Philippe Maillos
  • Sulfamate benzothiophene derivatives as steroid sulfatase inhibitors
    Patent number: 7476691
    Abstract: The present invention relates to sulfamate benzothiophene compounds of the formula: (I) wherein R1, R2, R3, m and n are as defined in the specification. The invention also relates to pharmaceutical compositions containing these compounds and to methods of using them.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: January 13, 2009
    Assignee: Laboratoire Theramex
    Inventors: Jean Lafay, Benoît Rondot, Denis Carniato, Paule Bonnet, Thierry Clerc, Jacqueline Shields, Igor Duc, Eric Duranti
  • 1-N-phenyl-amino-1h-imidazole derivatives and pharmaceutical compositions containing them
    Publication number: 20070112009
    Abstract: The invention relates to the compounds of formula (I): in which R1, R2, R3, R4, Q and Z are as defined in the specification. The invention also relates to the pharmaceutical compositions containing these compounds.
    Type: Application
    Filed: December 15, 2004
    Publication date: May 17, 2007
    Inventors: Jean Lafay, Benoit Rondot, Paule Bonnet, Thierry Clerc, Jaqueline Shields, Igor Duc, Eric Duranti, Francois Puccio, Christian Blot, Philippe Maillos
  • Sulfamatet benzothiophene derivatives as steroid sulfatase inhibitors
    Publication number: 20070021492
    Abstract: The present invention relates to sulfamate benzothiophene compounds of the formula: (I) wherein R1, R2, R3, m and n are as defined in the specification. The invention also relates to pharmaceutical compositions containing these compounds and to methods of using them.
    Type: Application
    Filed: May 16, 2003
    Publication date: January 25, 2007
    Inventor: Jean Lafay
  • Process for preparing medrogestone
    Publication number: 20060178520
    Abstract: A method for preparing medrogestone by heterogeneously palladium-catalyzed isomerization from 17?-methyl-6-methylenepregn-4-ene-3,20-dione.
    Type: Application
    Filed: January 17, 2006
    Publication date: August 10, 2006
    Applicant: Solvay Pharmaceuticals GmbH
    Inventors: Jean-Luc Moutou, Benoit Rondot, Jean Lafay, Philippe Maillos
  • 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors and pharmaceutical compositions containing them
    Patent number: 6737433
    Abstract: Imidazole derivatives of the formula: in which R1 and R2 are each independently hydrogen, (C1-C6)alkyl or (C3-C8)cycloalkyl; n is 0, 1 or 2; R3, R4, R5 and R6 are each independently hydrogen or a (C1-C6)alkyl, halogen, cyano, (C1-C6)alkoxy, trifluoromethyl, (C1-C6)alkylthio, (C1-C6)alkylsulfonyl, sulfonamido, acyl, (C1-C6)alkoxycarbonyl, or carboxamido group; R3 and R6 together with the phenyl ring bearing them can also form a benzofurane, or a N-methylbenzotriazole. The invention also relates to pharmaceutical compositions containing these derivatives, and to the uses thereof.
    Type: Grant
    Filed: December 16, 2002
    Date of Patent: May 18, 2004
    Assignee: Laboratoire Theramex
    Inventors: Nathalie Adje, Paule Bonnet, Denis Carniato, Remi Delansorne, Jean Lafay, Jean-Claude Pascal
  • 19-nor-pregnene derivatives and pharmaceuticals containing such derivatives
    Patent number: 6180803
    Abstract: The invention relates to compounds of the formula: in which R1, R2, R3, R4, R5, R6, n and X are as defined in the specification, and to pharmaceutical compositions containing them. These compounds are excellent progestogens which are devoid of residual androgenic activity.
    Type: Grant
    Filed: November 5, 1998
    Date of Patent: January 30, 2001
    Assignee: Laboratoire Theramex
    Inventors: Alain Piasco, Jean Lafay, R{acute over (e)}mi Delansorne, Jacques Paris, Jean-Claude Pascal