Patents by Inventor Jean Lepagnol

Jean Lepagnol has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050100650
    Abstract: Preparation by means of extrusion cooking of granules or powders from nuts and/or oleaginous fruits and/or oil seeds, which are optionally and partially defatted and/or dried in toto, the granules and powders being intended in particular for instant drinks. More specifically, the extrusion cooking method which is used in order to prepare the highly-nutritional granules or powders allows for the introduction of a high weight percentage (>/=40%) of the vegetable raw materials and for the concentration of the active ingredients and natural nutriments thereof.
    Type: Application
    Filed: October 3, 2002
    Publication date: May 12, 2005
    Inventors: Jean Lepagnol, Laura Barsotti, Arnaud Vannier-Moreau, Eric Prudhomme
  • Patent number: 6232319
    Abstract: The invention relates to compounds of general formula (I): in which R, R1, R2, X and Y are as defined in the description, their geometrical and/or optical isomers, and their addition salts with a pharmaceutically-acceptable acid or base, as well as to medicaments containing the same.
    Type: Grant
    Filed: June 4, 1999
    Date of Patent: May 15, 2001
    Assignee: Adir et Compagnie
    Inventors: Christian Marazano, Delphine Compere, Bhupesh Chandra Das, Jean Lepagnol
  • Patent number: 5776949
    Abstract: A compound of formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3, which are identical or different, represent hydrogen, halogen, alkyl, nitro, cyano, aminosulfonyl, imidazolyl, or pyrrolyl, or alternatively, when two of them are situated on adjacent carbons, may form with the carbon atoms to which they are attached a benzene ring on C.sub.3 -C.sub.7 cyloalkylR.sub.4 represents hydroxyl, alkoxy, phenoxy, or amino,their isomers as well as their addition salts with a pharmaceutically-acceptable base, and medicinal products containing the same which are useful as inhibitors of the the pathological phenomena linked to hyperactivation of the neurotransmission pathways by the excitatory amino acids.
    Type: Grant
    Filed: July 10, 1997
    Date of Patent: July 7, 1998
    Assignee: Adir et Compagnie
    Inventors: Alex Cordi, Patrice Desos, Jean Lepagnol, Philippe Morain, Pierre Lestage
  • Patent number: 5646132
    Abstract: Compound of formula (I): ##STR1## in which: R.sub.1, R.sub.2 and R.sub.3, which are identical or different, represent hydrogen or halogen or alkyl, nitro, cyano or aminosulfonyl, or alternatively, when two of them are located on adjacent carbons, form, with the carbon atoms to which they are attached, (C.sub.3 -C.sub.7) cycloalkyl ring or substituted or unsubstituted benzene ring,R.sub.4 represents hydrogen, linear or branched (C.sub.1 -C.sub.6) alkyl, substituted or unsubstituted phenyl or a group ##STR2## in which R.sub.6 and R.sub.7, which are identical or different, represent hydrogen or substituted or unsubstituted, linear or branched (C.sub.1 -C.sub.6) alkyl,R.sub.5 represents hydrogen, hydroxyl, linear or branched (C.sub.1 -C.sub.6) alkoxy, phenoxy, mercapto, linear or branched (C.sub.1 -C.sub.6) alkylthio, substituted or unsubstituted, linear or branched (C.sub.1 -C.sub.6) alkyl, substituted or unsubstituted phenyl or substituted or unsubstituted amino, or a group ##STR3## in which R.sub.6 and R.sub.
    Type: Grant
    Filed: July 10, 1995
    Date of Patent: July 8, 1997
    Assignee: Adir et Compagnie
    Inventors: Alex Cordi, Patrice Desos, Jean Lepagnol
  • Patent number: 5622957
    Abstract: A compound selected from those of general formula (I): ##STR1## wherein A represents a bivalent radical ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and Z are as defined in the description,the isomers and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of depression and anxiety.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: April 22, 1997
    Assignee: Adir et Compagnie
    Inventors: Jean-Daniel Brion, Claude Thal, Luc Demuynck, Jean-Gilles Parmentier, Jean Lepagnol, Pierre Lestage, Jean-Fran.cedilla.ois Pujol, Pascal Schmitt, Pierre Potier
  • Patent number: 5602131
    Abstract: A compound selected from those of general formula (I): ##STR1## wherein A represents a bivalent radical selected from ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and Z are as defined in the description,the isomers and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of depression and anxiety.
    Type: Grant
    Filed: December 13, 1994
    Date of Patent: February 11, 1997
    Assignee: Adir et Compagnie
    Inventors: Jean-Daniel Brion, Claude Thal, Luc Demuynck, Jean-Gilles Parmentier, Jean Lepagnol, Pierre Lestage, Jean-Fran.cedilla.ois Pujol, Pascal Schmitt, Pierre Potier
  • Patent number: 5536709
    Abstract: Compound of formula (I): ##STR1## in which R.sub.1, R.sub.2 and R.sub.3, which are identical or different, represent hydrogen or halogen or alkyl, nitro, cyano or aminosulfonyl, or alternatively, when two of them are located on adjacent carbons, form, with the carbon atoms to which they are attached, (C.sub.3 -C.sub.7) cycloalkyl ring or substituted or unsubstituted benzene ring,R.sub.4 represents hydrogen, linear or branched (C.sub.1 -C.sub.6) alkyl, substituted or unsubstituted phenyl or a group ##STR2## in which R.sub.6 and R.sub.7, which are identical or different, represent hydrogen or substituted or unsubstituted, linear or branched (C.sub.1 -C.sub.6) alkyl,R.sub.5 represents hydrogen, hydroxyl, linear or branched (C.sub.1 -C.sub.6) alkoxy, phenoxy, mercapto, linear or branched (C.sub.1 -C.sub.6) alkylthio, substituted or unsubstituted, linear or branched (C.sub.1 -.sub.6) alkyl, substituted or unsubstituted phenyl or substituted or unsubstituted amino; or a group ##STR3## in which R.sub.6 and R.sub.
    Type: Grant
    Filed: August 30, 1994
    Date of Patent: July 16, 1996
    Assignee: Adir et Compagnie
    Inventors: Alex Cordi, Patrice Desos, Jean Lepagnol
  • Patent number: 5536719
    Abstract: A compound of formula (I): ##STR1## in the form of its S enantiomer, its addition salts with a pharmaceutically acceptable acid or base and medicinal product containing the same are useful for the treatment or prevention of pathologies associated with dysfunction of glutamatergic neurotransmission.
    Type: Grant
    Filed: July 11, 1995
    Date of Patent: July 16, 1996
    Assignee: Adir et Compagnie
    Inventors: Alex Cordi, Michael Spedding, Bernard Serkiz, Jean Lepagnol, Patrice Desos, Philippe Morain
  • Patent number: 5506237
    Abstract: The invention relates to the compounds of formula (I): ##STR1## in which: A represents, with the carbon and nitrogen atoms to which it is attached, a heterocycle,B represents, with the nitrogen atom to which it is attached, a heterocycle,n is equal to 1, 2, 3 or 4,R represents phenyl substituted by at least one halogen or alkyl, hydroxyl, alkoxy, trifluoromethyl, nitro, amino, cyano, carboxyl or alkoxycarbonyl, benzyl, thienyl or pyridyl. The compounds may be used as medicaments.
    Type: Grant
    Filed: March 23, 1994
    Date of Patent: April 9, 1996
    Assignee: Adir et Compagnie
    Inventors: Guillaume De Nanteuil, Bernard Protevin, Georges Remond, Jean Lepagnol, Veronique Heidet
  • Patent number: 5492913
    Abstract: The compounds are N-(unsubstituted or substituted) N'-benzylpiperazine compounds and pharmaceutically tolerable salts thereof, useful for treating neuronal disorders resulting from the dysfunctioning of oxidative metabolism.A compound disclosed is: N-ethyl N'-(2-hydroxy-3,4- dimethoxybenzyl)-piperazine and its dihydrochloride.
    Type: Grant
    Filed: March 23, 1994
    Date of Patent: February 20, 1996
    Assignee: Adir et Compagnie
    Inventors: Michel Wierzbicki, Jean Lepagnol, Jean-Paul Tillement, Bernard Testa, Yves Rolland
  • Patent number: 5459138
    Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## in which A, R.sub.1, R.sub.2 and R.sub.4 are as defined in the description,and medicinal products containing the same which is useful for treating a pathology related to dysfunctioning of glutamatergic neurotransmission.
    Type: Grant
    Filed: March 24, 1994
    Date of Patent: October 17, 1995
    Assignee: Adir et Compagnie
    Inventors: Bernard Pirotte, Pascal de Tullio, Bernard Masereel, Jacques Delarge, Jean Lepagnol, Pierre Renard
  • Patent number: 5384322
    Abstract: The invention relates to the compounds of formula (I): ##STR1## in which: A represents, with the nitrogen and carbon atoms to which it is bound, a heterocycle,B represents, with the nitrogen atom to which it is bound, a heterocycle,R.sub.1 represents alkoxy, benzyloxy, phenoxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or substituted or unsubstituted cycloalkyl,their enantiomers, diastereoisomers and epimers as well as their addition salts with a pharmaceutically acceptable acid, medicinal products containing the same.
    Type: Grant
    Filed: September 30, 1993
    Date of Patent: January 24, 1995
    Assignee: Adir et Compagnie
    Inventors: Michel Vincent, Georges Remond, Bernard Portevin, Yolande Herve, Jean Lepagnol, Guillaume de Nanteuil
  • Patent number: 5286732
    Abstract: The invention relates to the compounds of formula (I): ##STR1## in which: A represents, with the nitrogen and carbon atoms to which it is bound, a heterocycle,B represents, with the nitrogen atom to which it is bound, a heterocycle,R.sub.1 represents alkoxy, benzyloxy, phenoxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or substituted or unsubstituted cycloalkyl,their enantiomers, diastereoisomers and epimers as well as their addition salts with a pharmaceutically acceptable acid, medicinal products containing the same.
    Type: Grant
    Filed: September 25, 1992
    Date of Patent: February 15, 1994
    Assignee: Adir et Compagnie
    Inventors: Michel Vincent, Georges Remond, Bernard Portevin, Yolande Herve, Jean Lepagnol, Guillaume de Nanteuil
  • Patent number: 5190923
    Abstract: The invention relates to compounds of formula (I): ##STR1## in which: A represents, with the carbon and nitrogen atoms to which it is linked, cyclic amide as defined in the description,B represents, with the nitrogen and carbon atoms to which it is linked, saturated polycyclic structure as defined in the description,R represents hydrogen, optionally substituted lower alkyl, optionally substituted (4-imidazolyl)methyl, (3-pyrazolyl)methyl or optionally substituted (2-pyridyl)methyl,their enantiomers, diastereoisomers and epimers as well as their addition salts with a pharmaceutically acceptable acid.Medicinal products.
    Type: Grant
    Filed: June 4, 1991
    Date of Patent: March 2, 1993
    Assignee: Adir Et Compagnie
    Inventors: Michel Vincent, Georges Remond, Bernard Portevin, Yolande Herve, Jean Lepagnol
  • Patent number: 5151432
    Abstract: The invention relates to the compounds of formula (I): ##STR1## in which: R.sub.1 represents a linear or branched, lower or higher alkoxy group or a substituted or unsubstituted amino group,R.sub.2 represents a lower alkyl group unsubstituted or substituted with an amino group,R.sub.3 represents an amino, lower or higher alkoxy or a hydroxyl group, with the proviso, however, that at least one amino group is present in R.sub.1 or R.sub.3,R.sub.4 represents a hydrogen atom or an aryl group,m is equal to 1 or 2,n is between 1 and 6, andRa and Rb, which may be identical or different, represent a hydrogen atom when m=1, or a hydrogen atom or an alkyl group when m=2 andmedicinal products.
    Type: Grant
    Filed: December 19, 1990
    Date of Patent: September 29, 1992
    Assignee: Adir et Compagnie
    Inventors: Michel Vincent, Georges Remond, Bernard Portevin, Yolande Herve, Jean Lepagnol
  • Patent number: 5098888
    Abstract: The invention relates to the compounds of general formula (I): ##STR1## in which: A represents, with the carbon and nitrogen atoms to which it is linked, a cycloamide group,B represents, with the carbon and nitrogen atoms to which it is linked, a saturated polycyclic structure,R represents a hydrogen atom, alower alkyl group or a substituted or unsubstituted 4-imidazolylmethyl group,their diastereoisomers, enantiomers and epimers, as well as their addition salts with a pharmaceutically acceptable acid.Medicinal products.
    Type: Grant
    Filed: June 11, 1990
    Date of Patent: March 24, 1992
    Assignee: Adir et Compagnie
    Inventors: Michel Vincent, Georges Remond, Bernard Portevin, Yolande Herve, Jean Lepagnol, Catherine Biton
  • Patent number: 5066651
    Abstract: New pyrrolidone compounds of the formula: ##STR1## in which: R is OR", SR" or N (R.sub.3 R.sub.4)R' is optionally substituted alkyl or aryl, andthe carbon in the 5-position of the pyrrolidone ring, which is substituted by CH.sub.2 R has the R or S configuration.These new compounds and their physiologically tolerable salts may be used therapeutically especially in the treatment of asthenias, ischaemic syndromes and nervous disorders associated with normal or pathological ageing.
    Type: Grant
    Filed: May 17, 1990
    Date of Patent: November 19, 1991
    Assignee: Adir et Compagnie
    Inventors: Gilbert Regnir, Alain Dhainaut, Jean Lepagnol, Jean Lepagnol
  • Patent number: 5026701
    Abstract: New morpholine compounds of the formula: ##STR1## in which: X, bonded to the aromatic nucleus, represents halogen or trifluoromethyl and R' represents hydrogen, (C.sub.1 -C.sub.5)alkyl optionally including a double bond, or aralkyl; in racemic and enantiomeric forms, and physiologically tolerable acid addition salts theroef.These compounds and their physiologically tolerable salts can be used therapeutically especially in the treatment of ischaemic syndromes and cerebral ageing.
    Type: Grant
    Filed: October 25, 1990
    Date of Patent: June 25, 1991
    Assignee: Adir et Compagnie
    Inventors: Gilbert Regnier, Claude Guillonneau, Jean Lepagnol, Pierre Lestage
  • Patent number: 4886799
    Abstract: The invention relates to new acetamides derived from 2,3-dihydro-3-phenyl-2-benzofuranone, of general formula I ##STR1## in which: R.sub.1 denotes a hydrogen or halogen atom,R.sub.2 and R.sub.3, which may be identical or different, each denote a hydrogen atom or a linear or branched alkyl radical containing 1 to 4 carbon atoms, a benzyl radical optionally substituted with a halogen atom, with an alkoxy radical containing 1 to 4 carbon atoms or with an alkyl radical having 1 to 4 carbon atoms, or a 3,4-methylene-dioxybenzyl radical, or form, together with the nitrogen to which they are attached, a 4-morpholinyl radical or a 1-piperazinyl radical.
    Type: Grant
    Filed: September 14, 1988
    Date of Patent: December 12, 1989
    Assignee: Adir Et Cie
    Inventors: Gilbert Lavielle, Jean Lepagnol
  • Patent number: 4885299
    Abstract: The invention relates to new 2-(2,3-dihydro-2-oxo-3-benzofuranyl)acetic acid compounds of general formula I: ##STR1## in which: R.sub.1 denotes a hydrogen atom, a linear or branched alkyl radical having 1 to 4 carbon atoms or a phenyl radical optionally substituted with a halogen atom or with an alkoxy radical containing 1 to 4 carbon atoms or an alkyl radical having 1 to 4 carbon atoms,R.sub.2 denotes a hydrogen or halogen atom, a hydroxyl radical, an alkyl radical having 1 to 4 carbon atoms or an alkoxy radical containing 1 to 4 carbon atoms,R denotes a hydroxyl radical, a linear or branched alkoxy radical having 1 to 4 carbon atoms, a benzyloxy radical or a radical of general formula A: ##STR2## in which: X and Y, which may be identical or different, each denote a linear or branched alkyl radical containing 1 to 5 carbon atoms, a radical of general formula A.sub.
    Type: Grant
    Filed: January 17, 1989
    Date of Patent: December 5, 1989
    Assignee: ADIR Et Cie
    Inventors: Gilbert Lavielle, Jean Lepagnol