Abstract: A method is provided for manipulating objects in a cavity including a liquid, the method including providing in at least one region of the cavity objects capable of absorbing light in a given wavelength range, forming an aggregate of the objects by submitting them to an acoustic field, and disrupting the aggregate by submitting the aggregate to a light beam emitting at the given wavelength range. Also provided is a device for manipulating objects.

Abstract: A microfluidic chip, in particular for a cell culture, the chip including a block made from biocompatible material, a passage channel made in the block for the passage of cells bathed in a liquid, in particular a nutrient liquid, a resonant cavity made in the block, connected to the passage channel and including walls for containing the cells originating from the passage channel, a generator generating acoustic waves capable of forming at least one cell aggregate in acoustic levitation in the resonant cavity, and at least one optical emitter capable of illuminating cells in the resonant cavity through at least one wall of the resonant cavity and simultaneous to the generation of acoustic waves in such a way as to structure the at least one aggregate by means of the optical exclusion technique.

Abstract: A method is provided for manipulating objects in a cavity including a liquid, the method including providing in at least one region of the cavity objects capable of absorbing light in a given wavelength range, forming an aggregate of the objects by submitting them to an acoustic field, and disrupting the aggregate by submitting the aggregate to a light beam emitting at the given wavelength range. Also provided is a device for manipulating objects.

Abstract: The invention relates to a device (1) intended for handling objects (O) present in a channel (2) within a fluid (F), in particular a liquid. The device comprises: a channel (2) extending along a longitudinal axis (X), said channel (2) having a transverse section with a width (_) measured along a first transverse axis (Y) and a thickness measured along a second transverse axis (Z) perpendicular to the first, said width (_) being greater than or equal to the thickness, and said channel comprising first (3) and second (4) walls along the second transverse axis (Z); and an acoustic wave generator (10) generating acoustic waves in the channel from at least one of the walls (3; 4), said acoustic wave generator (10) operating at a frequency f that is different from a resonant frequency f0 of the channel (2) along the second transverse axis (Z).