Patents by Inventor Jean-Luc Coll
Jean-Luc Coll has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11529316Abstract: The invention relates to a novel use of ultrafine nanoparticles, of use as a diagnostic, therapeutic or theranostic agent, characterized by their mode of administration via the airways. The invention is also directed toward the applications which follow from this novel mode of administration, in particular for imaging the lungs, and the diagnosis or prognosis of pathological pulmonary conditions. In the therapeutic field, the applications envisioned are those of radiosensitizing or radioactive agents for radiotherapy (and optionally curietherapy), or for neutron therapy, or of agents for PDT (photodynamic therapy), in particular for the treatment of lung tumors.Type: GrantFiled: December 6, 2019Date of Patent: December 20, 2022Assignees: Universite Claude Bernard Lyon I, Nano-H, Centre National de la Recherche Scientifique—CNRS, Universite Grenoble Alpes, Universite de BordeauxInventors: Yannick Cremillieux, Andrea Bianchi, Sandrine Dufort, Jean-Luc Coll, Francois Lux, Olivier Tillement
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Publication number: 20220322945Abstract: The present invention relates to the use of an aza-BODIPY fluorophore compound as a contrast agent in the optical window ranging from 1000 to 1700 nm. The invention also relates to the use, as a contrast agent, of a composition comprising said fluorophore compound and a pharmaceutically acceptable excipient and/or a solvent, in a kit comprising an injection system and said fluorophore or said composition, and also to a method for identifying a biological target (such as a healthy or tumour cell, a protein, DNA, RNA, for example).Type: ApplicationFiled: August 4, 2020Publication date: October 13, 2022Inventors: Lucie SANCEY, Christine GOZE, Ewen BODIO, Benoît BUSSER, Jacques PLIQUETT, Amélie GODARD, Ghadir KALOT, Véronique JOSSERAND, Xavier LE GUÉVEL, Jean-Luc COLL, Franck DENAT
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Publication number: 20200108155Abstract: The invention relates to a novel use of ultrafine nanoparticles, of use as a diagnostic, therapeutic or theranostic agent, characterized by their mode of administration via the airways. The invention is also directed toward the applications which follow from this novel mode of administration, in particular for imaging the lungs, and the diagnosis or prognosis of pathological pulmonary conditions. In the therapeutic field, the applications envisioned are those of radiosensitizing or radioactive agents for radiotherapy (and optionally curietherapy), or for neutron therapy, or of agents for PDT (photodynamic therapy), in particular for the treatment of lung tumors.Type: ApplicationFiled: December 6, 2019Publication date: April 9, 2020Applicants: Universite Claude Bernard Lyon I, Nano-H, Centre National de la Recherche Scientifique - CNRS, Universite Grenoble Alpes, Universite de BordeauxInventors: Yannick CREMILLIEUX, Andrea BIANCHI, Sandrine DUFORT, Jean-Luc COLL, Francois LUX, Olivier TILLEMENT
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Patent number: 10517962Abstract: The invention relates to a novel use of ultrafine nanoparticles, of use as a diagnostic, therapeutic or theranostic agent, characterized by their mode of administration via the airways. The invention is also directed toward the applications which follow from this novel mode of administration, in particular for imaging the lungs, and the diagnosis or prognosis of pathological pulmonary conditions. In the therapeutic field, the applications envisioned are those of radiosensitizing or radioactive agents for radiotherapy (and optionally curietherapy), or for neutron therapy, or of agents for PDT (photodynamic therapy), in particular for the treatment of lung tumors.Type: GrantFiled: April 12, 2013Date of Patent: December 31, 2019Assignees: Universite Claude Bernard Lyon I, Nano-H, Universite Grenoble Alpes, Universite de Bordeaux, Centre National de la Recherche ScientifiqueInventors: Yannick Cremillieux, Andrea Bianchi, Sandrine Dufort, Jean-Luc Coll, Francois Lux, Olivier Tillement
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Publication number: 20170327561Abstract: The present invention relates to a peptide comprising an amino acid sequence at least 85% identical to the amino acid sequence as shown in SEQ ID NO. 1, wherein the residues Lys905, Arg909, and Arg912 contained therein are present, for use as a medicament, in particular for its use as an inhibitor of FGF-2 induced angiogenesis.Type: ApplicationFiled: December 2, 2014Publication date: November 16, 2017Inventors: Florence Ruggiero, Rachel Manuel, Jean-Luc Coll, Michelle Keramidas
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Patent number: 9421281Abstract: The invention concerns the field of molecular probe architecture for in vivo imaging. More particularly, the invention concerns molecular constructs providing an imaging function activable in intracellular environment. The inventive fluorescence probes enable in particular images of certain targeted tissues to be formed, while maintaining a low background noise level and, preferably, while obtaining at the targeted tissue, an imaging signal increasing in time.Type: GrantFiled: July 18, 2006Date of Patent: August 23, 2016Assignees: Centre National de la Recherche Scientifique, Commissariat a l'Energie Atomique et aux Energies Alternatives, Institut National de la Sante et de la Recherche Medicale (INSERM), The Joseph Fourier University of GrenobleInventors: Isabelle Texier-Nogues, Jean-Luc Coll, Pascal Dumy, Didier Boturyn, Marie Favrot
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Publication number: 20150050217Abstract: The invention relates to a novel use of ultrafine nanoparticles, of use as a diagnostic, therapeutic or theranostic agent, characterized by their mode of administration via the airways. The invention is also directed toward the applications which follow from this novel mode of administration, in particular for imaging the lungs, and the diagnosis or prognosis of pathological pulmonary conditions. In the therapeutic field, the applications envisioned are those of radiosensitizing or radioactive agents for radiotherapy (and optionally curietherapy), or for neutron therapy, or of agents for PDT (photodynamic therapy), in particular for the treatment of lung tumors.Type: ApplicationFiled: April 12, 2013Publication date: February 19, 2015Applicants: Universite Claude Bernard Lyon I, Nano-H, Centre National de la Recherche Scientifique-CNRS, Universite Joseph FourierInventors: Yannick Cremillieux, Andrea Bianchi, Sandrine Dufort, Jean-Luc Coll, Francois Lux, Olivier Tillement
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Patent number: 8513394Abstract: A fluorescent enzymatic substrate including a backbone saccharide nature having at least one saccharide unit. The saccharide unit includes a fluorophore F1 and an inhibitor I1 of the fluorescence of F1. The fluorophore F1 and the inhibitor I1, either directly or by the spacer arms B1 and B2, respectively, when at least one B1 and B2 is present, are grafted on the same saccharide unit of the backbone saccharide. One of th groups is F1 and I1 grafted in the anomeric position 1 of the saccharide unit.Type: GrantFiled: July 21, 2006Date of Patent: August 20, 2013Assignees: Commissariat a l'Energie Atomique, Institut National de la Sante et de la Recherche Medicale (Inserm), Centre National de la Recherche ScientifiqueInventors: Isabelle Texier-Nogues, Véronique Robert, Jean-Luc Coll, Anne Imberty
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Patent number: 7531622Abstract: A method for preparing a grafted homodetic cyclopeptide forming a framework that defines a grafted upper face and grafted lower face, including synthesizing a linear peptide from modified or unmodified amino acids, some of which carry orthogonal protective groups; intramolecular cyclizing the resulting protected linear peptide; substituting some or all of orthogonal protective groups with a protected precursor; and grafting at least one molecule of interest onto one and/or the other face of the framework via an oxime bond.Type: GrantFiled: September 19, 2003Date of Patent: May 12, 2009Assignees: Centre National de la Recherche Scientifique- CNRS, Universite Joseph Fourier, InsermInventors: Pascal Dumy, Marie-Christine Favrot, Didier Boturyn, Jean-Luc Coll
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Publication number: 20080299044Abstract: The invention concerns saccharide type fluorescent enzymatic substrates comprising on the same saccharide unit a fluorophor F1 and an inhibitor of the fluorescence of F1, and their use for preparing a diagnostic reagent for in vivo functional imaging, as well as a diagnostic reagent containing at least such an enzymatic substrate.Type: ApplicationFiled: July 21, 2006Publication date: December 4, 2008Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE, INSTITUT NAT DE LA SANTE ET DE LA RECHERCHE MED, CENTRE NAT DE LA RECHERCHE SCIENTIFIQUEInventors: Isabelle Texier-Nogues, Veronique Robert, Jean-Luc Coll, Anne Imberty
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Publication number: 20080292556Abstract: The invention concerns the field of molecular probe architecture for in vivo imaging. More particularly, the invention concerns molecular constructs providing an imaging function activable in intracellular environment, said constructs being further bound to a vector which enables certain cells to be targeted, and said cells to be internalized. The inventive fluorescence probes enable in particular images of certain targeted tissues to be formed, while maintaining a low background noise level and, preferably, while obtaining at the targeted tissue, an imaging signal increasing in time.Type: ApplicationFiled: July 18, 2006Publication date: November 27, 2008Applicants: Commissariat A L'Energie Atomique, Institut National de la Sante et de la Recher. Med, Universite Joseph FourierInventors: Isabelle Texier-Nogues, Jean-Luc Coll, Pascal Dumy, Didier Boturyn, Marie Favrot
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Publication number: 20060173160Abstract: A method for preparing a grafted homodetic cyclopeptide froming a framework that defines a grafted upper face and grafted lower face, including synthesizing a linear peptide from modified or unmodified amino acids, some of which carry orthogonal protective groups; intramolecular cyclizing the resulting protected linear peptide; substituting some or all of orthogonal protective groups with a protected precursor; and grafting at least one molecule of interest onto one and/or the other face of the framework via an oxime bond.Type: ApplicationFiled: September 19, 2003Publication date: August 3, 2006Inventors: Pascal Dumy, Marie-Christine Favrot, Didier Boturyn, Jean-Luc Coll