Abstract: The present invention relates to the use of HTRA1 mRNA antagonists in the treatment of eye disorders, such as macular degeneration, and the use of an HTRA1 levels in the aqueous and vitreous humor as a diagnostic biomarker for the suitability of treatment of a subject with an HTRA1 mRNA antagonist.

Abstract: A lipid particle comprising an apolipoprotein, a phosphatidylcholine and a lipid, such as a phospholipid, fatty acid or steroid lipid. In one embodiment the lipid particle comprises only one apolipoprotein. In one embodiment the lipid particle is consisting of one apolipoprotein, a phospholipid, a lipid, and a detergent. In one embodiment the lipid is a second phosphatidylcholine, wherein the first phosphatidylcholine and the second phosphatidylcholine differ in one or two fatty acid residues or fatty acid residue derivatives which are esterified to the glycerol backbone of the phosphatidylcholine. In one embodiment the apolipoprotein is selected from an apolipoprotein that has the amino acid sequence selected from SEQ ID NO: 01, 02, 06, 66, and 67, or is a variant thereof that has at least 70% sequence identity with the selected sequence.

Abstract: A lipid particle comprising an apolipoprotein, a phosphatidylcholine and a lipid, such as a phospholipid, fatty acid or steroid lipid. In one embodiment the lipid particle comprises only one apolipoprotein. In one embodiment the lipid particle is consisting of one apolipoprotein, a phospholipid, a lipid, and a detergent. In one embodiment the lipid is a second phosphatidylcholine, wherein the first phosphatidylcholine and the second phosphatidylcholine differ in one or two fatty acid residues or fatty acid residue derivatives which are esterified to the glycerol backbone of the phosphatidylcholine. In one embodiment the apolipoprotein is selected from an apolipoprotein that has the amino acid sequence selected from SEQ ID NO: 01, 02, 06, 66, and 67, or is a variant thereof that has at least 70% sequence identity with the selected sequence.

Abstract: These objects are achieved by a method of acoustically inspecting a one-piece bladed wheel in which the wheel is driven in rotation; each blade of the wheel is subjected to mechanical excitation; its acoustic response is picked up and a corresponding electrical signal is generated; its frequency response is determined by computing a FFT; the electrical signal and the associated frequency response are stored; the characteristic frequencies of each blade of the wheel are identified; and a wheel is rejected or accepted depending on whether or not the frequency distribution obtained in this way matches a predetermined set of forbidden frequency distributions. Advantageously, an additional step is provided in which the defects of a blade are determined by comparing its frequency response with predetermined frequency responses that are characteristic of various types of defect.

Abstract: These objects are achieved by a method of acoustically inspecting a one-piece bladed wheel in which the wheel is driven in rotation; each blade of the wheel is subjected to mechanical excitation; its acoustic response is picked up and a corresponding electrical signal is generated; its frequency response is determined by computing a FFT; the electrical signal and the associated frequency response are stored; the characteristic frequencies of each blade of the wheel are identified; and a wheel is rejected or accepted depending on whether or not the frequency distribution obtained in this way matches a predetermined set of forbidden frequency distributions. Advantageously, an additional step is provided in which the defects of a blade are determined by comparing its frequency response with predetermined frequency responses that are characteristic of various types of defect.