Patents by Inventor Jean-Marc Lalouel

Jean-Marc Lalouel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Drug screening and diagnosis based on paracrine tubular renin-angiotensin system
    Patent number: 7749725
    Abstract: The present invention relates to a method for screening drugs for use in treating hypertension using the tubular renin-angiotensinogen system identified by the present invention. The invention further relates to a method to diagnose sodium status and sensitivity in an individual by measuring urinary angiotensinogen or angiotensin-I.
    Type: Grant
    Filed: October 16, 2002
    Date of Patent: July 6, 2010
    Assignee: University of Utah Research Foundation
    Inventors: Andreas Rohrwasser, Terry Morgan, Jean-Marc Lalouel
  • Variants of NEDD4L associated with hypertension and viral budding
    Publication number: 20050277123
    Abstract: Disclosed are compositions and methods related to NEDD4L, a ubiquitin ligase, and hypertension as well as viral budding. A systematic search for genetic polymorphism was conducted by resequencing exon and intron boundaries in human genomic DNA. Isoforms encoding a Ca2+-dependent lipid binding C2 domain at the N-terminus of NEDD4L were identified. Additional isoforms lacing the Ca2+-dependent lipid binding C2 domain were also identified. A common polymorphism was identified, Variant 13, with either G (70%) or A (30%) as the last nucleotide of exon 1, which effects splice site finction and formation of the Ca2+-dependent lipid binding C2 domain. Identified isoforms are present in both kidney and adrenal samples.
    Type: Application
    Filed: August 26, 2004
    Publication date: December 15, 2005
    Inventors: Robert Weiss, Jean-Marc Lalouel, James Pankow, Diane Dunn
  • Molecular variants, haplotypes and linkage disequilibrium within the human angiotensinogen gene
    Publication number: 20030219776
    Abstract: The present invention relates to methods for assessing risk of hypertension in als by identifying the molecular variants or haplotypes of the angiotensinogen (AGT) gene.
    Type: Application
    Filed: December 18, 2002
    Publication date: November 27, 2003
    Inventors: Jean-Marc Lalouel, Andreas Rohrwasser, Tomoaki Ishigami, Mitsuru Emi, Toshiaki Nakajima, Ituro Inoue
  • Drug screening and diagnosis based on paracrine tubular renin-angiotensin system
    Publication number: 20030036208
    Abstract: The present invention relates to a method for screening drugs for use in treating hypertension using the tubular renin-angiotensinogen system identified by the present invention. The invention further relates to a method to diagnose sodium status and sensitivity in an individual by measuring urinary angiotensinogen or angiotensin-I.
    Type: Application
    Filed: October 16, 2002
    Publication date: February 20, 2003
    Applicant: University of Utah Research Foundation, a Utah corporation
    Inventors: Andreas Rohrwasser, Terry Morgan, Jean-Marc Lalouel
  • Drug screening and diagnosis based on paracrine tubular renin-angiotensin system
    Patent number: 6495338
    Abstract: The present invention relates to a method for screening drugs for use in treating hypertension using the tubular renin-angiotensinogen system identified by the present invention. The invention further relates to a method to diagnose sodium status and sensitivity in an individual by measuring urinary angiotensinogen or angiotensin-I.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: December 17, 2002
    Assignee: University of Utah Research Foundation
    Inventors: Andreas Rohrwasser, Terry Morgan, Jean-Marc Lalouel
  • Method to determine predisposition to hypertension
    Patent number: 6177252
    Abstract: The T/C(67) AGT gene variant and the association of the molecular variant C(67) with predisposition of an individual to hypertension are disclosed. The determination of this association enables the screening of persons to identify the severity of hypertension or the severity of the risk of a predisposition to high blood pressure.
    Type: Grant
    Filed: August 27, 1999
    Date of Patent: January 23, 2001
    Assignee: University of Utah Research Foundation
    Inventors: Andreas Rohrwasser, Jean-Marc Lalouel
  • Method to determine predisposition to hypertension
    Patent number: 6165727
    Abstract: The association of the molecular variant G-6A of the angiotensinogen gene with human hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood presure.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: December 26, 2000
    Assignees: University of Utah Research Foundation, Inserm
    Inventors: Jean-Marc Lalouel, Xavier Jeunemaitre, Richard P. Lifton, Florent Soubrier, Youri Kotelevtsev, Pierre Corvol
  • Method to determine predisposition to hypertension
    Patent number: 6153386
    Abstract: The association of the molecular variant A-20C of the angiotensinogen gene with the prognosis of human hypertension as determined by the G-6A molecular variant is disclosed. The determination of this association enables the screening of persons to identify the severity of hypertension or the severity of the risk of a predisposition to high blood pressure.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: November 28, 2000
    Assignee: University of Utah Research Foundation
    Inventors: Jean-Marc Lalouel, Xavier Jeunemaitre
  • Method to determine predisposition to hypertension
    Patent number: 5998145
    Abstract: The association of the molecular variant G-6A of the angiotensinogen gene with human hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood pressure.
    Type: Grant
    Filed: June 8, 1998
    Date of Patent: December 7, 1999
    Assignees: Univ. of Utah Research Foundation, INSERM
    Inventors: Jean-Marc Lalouel, Xavier Jeunemaitre, Richard P. Lifton, Florent Soubrier, Youri Kotelevtsev, Pierre Corvol
  • Method to determine predisposition to hypertension
    Patent number: 5763168
    Abstract: The association of the molecular variant G-6A of the angiotensinogen gene with human hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood presure.
    Type: Grant
    Filed: October 7, 1994
    Date of Patent: June 9, 1998
    Assignees: University of Utah Research Foundation, INSERM
    Inventors: Jean-Marc Lalouel, Xavier Jeunemaitre, Richard P. Lifton, Florent Soubrier, Youri Kotelevtsev, Pierre Corvol
  • Angiotensinogen gene variants and predisposition to hypertension
    Patent number: 5589584
    Abstract: The association of molecular variants of the angiotensinogen gene with human essential hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood presure.
    Type: Grant
    Filed: July 1, 1994
    Date of Patent: December 31, 1996
    Assignee: University of Utah Research Foundation
    Inventors: Jean-Marc Lalouel, Xavier Jeunemaitre, Richard P. Lifton, Florent Soubrier, Youri Kotelevtsev, Pierre Corvol
  • Direct genetic test for glucocorticoid-remediable aldosteronism
    Patent number: 5529900
    Abstract: A method of screening for glucocorticoid remediable aldosteronism (GRA) in a mammal by detecting the presence or absence of a chimaeric gene duplication resulting from unequal crossing over of the 11, .beta.-hydroxylase and aldosterone synthase genes, or the product encoded by the chimaeric gene duplication. Presence of the chimaeric gene duplication or its encoded product is indicative of a mammal afflicted with GRA and absence of the chimaeric gene duplication or its product is indicative of a mammal not afflicted with GRA.
    Type: Grant
    Filed: January 8, 1993
    Date of Patent: June 25, 1996
    Assignees: Brigham and Women's Hospital, University of Utah
    Inventors: Richard P. Lifton, Jean-Marc Lalouel
  • Methods to determine predisposition to hypertension and association of variant angiotensinogen gene and hypertension
    Patent number: 5374525
    Abstract: The association of molecular variants of the angiotensinogen gene with human hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood presure.
    Type: Grant
    Filed: September 30, 1992
    Date of Patent: December 20, 1994
    Assignees: University of Utah Research Foundation, Inserm
    Inventors: Jean-Marc Lalouel, Xavier Jeunemaitre, Richard P. Lifton, Florant Soubrier, Youri Kotelevtsev, Pierre Corval