Abstract: The invention concerns a method for preparing a double emulsion of a fat-soluble and hydrophobic active ingredient, which comprises the following steps: (a) Providing an aqueous solution of at least one whey protein; (b) Providing an aqueous solution of at least one anionic polysaccharide; (c) Subjecting the whey protein(s) to a denaturation treatment; (d) Hot-preparing an o/w emulsion of the active ingredient in the solution (c), then hot-preparing an (o/w)/w emulsion of the o/w emulsion in the solution (b), or (e) Preparing an w/w emulsion of the solutions (c) and (b), then hot-preparing an o/(w/w) emulsion of the active ingredient in the w/w emulsion. It also concerns the manufacturing of particles of said active ingredient from a thus prepared emulsion, and the obtained particles.

Abstract: A method for preparing fat-soluble active ingredients, including the steps of preparing an oil-in-water emulsion including 8 to 20% of at least one protein, 5 to 15% of at least one sugar, 0.5 to 3% of at least one inorganic salt, 10 to 22% of at least one fat-soluble active ingredient in an oily form and/or dissolved in an edible oil, and qsp % of water, shaping of particles in a substantially spherical shape by the dispersing the oil-in-water emulsion obtained at the end of step a) in a fluid, adding at least one agent for cross-linking of the at least one protein to the dispersion obtained at the end of step b), and the active ingredients are recovered with the substantially spherical shape.

Abstract: The present invention relates to a process for preparing cores of granules intended for animal nutrition, the said cores comprising: a hydrophilic active principle present in an active content of greater than or equal to 60% by weight, at least one meltable binder, at least one plasticizer, the said process comprising (a) a first step of mixing of the ingredients, (b) a second step of extrusion of the mixture through an extruder, especially a single-screw or twin-screw extruder, equipped with one or more dies, so as to obtain rods, and (c) a third step of spheronization of the rods, the said process being characterized in that a preliminary dry co-grinding of the ingredients is performed before extruding the mixture, the said co-grinding being performed at a temperature of not more than 50° C. The present invention also relates to a process for preparing granules of hydrophilic active principle comprising the said cores.

Abstract: The invention relates to a method for producing fat-soluble active principles, in particular pharmaceutical and/or dietary fat-soluble active principles, in the form of particles. The invention is characterized in that said method comprises the following steps: a) preparation of an oil-in-water emulsion comprising, in weight per cent relative to the total weight of said emulsion: between 8 and 20%, preferably between 10 and 15%, of at least one protein, between 5 and 15%, preferably between 8 and 12%, of at least one sugar, between 0.

Abstract: The present invention relates to cores of granules of hydrophilic active principle, characterized in that they also comprise starch or a derivative thereof. The present invention also relates to hydrophilic active principle granules intended for the nutrition or treatment of ruminants.

Abstract: The present invention relates to a process for preparing cores of granules intended for animal nutrition, the said cores comprising: a hydrophilic active principle present in an active content of greater than or equal to 60% by weight, at least one meltable binder, at least one plasticizer, the said process comprising (a) a first step of mixing of the ingredients, (b) a second step of extrusion of the mixture through an extruder, especially a single-screw or twin-screw extruder, equipped with one or more dies, so as to obtain rods, and (c) a third step of spheronization of the rods, the said process being characterized in that a preliminary dry co-grinding of the ingredients is performed before extruding the mixture, the said co-grinding being performed at a temperature of not more than 50° C. The present invention also relates to a process for preparing granules of hydrophilic active principle comprising the said cores.

Abstract: The homogeneous solid granules of the invention comprise at least 5% (w/w) of carotenoid, gelatine and a sugar, they have a size distribution of from 100 ?m to 2000 gm and are solvent-free. The process for producing such granules comprises the following steps: (a) preparing an aqueous solution of at least gelatine and a sugar, (b) adding at least said carotenoid in said aqueous solution, (c) adding the preparation obtained in (b) to an oil to obtain an emulsion of granules, (d) cooling said emulsion to solidify the granules, and (e) recovering and drying the granules.

Abstract: An animal rumen-resistant feed supplement in the solid form, said feed supplement comprising at least one methionine derivative and a porous carrier material wherein (a) said methionine derivative is selected from the group consisting of liquid and solid esters of the 2-hydroxy-4-(methylthio)butanoic acid, with the proviso that solid esters have a melting point of 100° C. at most; the 2-amino-4-methylthiobutanamide and the 2-hydroxy-4-methylthiobutanamide, (b) said methionine derivative accounts for at least 20% and up to 70% by weight of the feed supplement and (c) said supplement is in the form of particles having a size range of from 80 to 600 microns.

Abstract: A liquid vitamin composition comprising (a) a first liquid vitamin formulation comprising vitamins A, D3, B12 and optionally vitamin E, (b) a second liquid vitamin formulation comprising vitamins B1, B2, B3, B5, B6, and H, and (c) a third liquid vitamin formulation comprising vitamin K3 wherein the three formulations are separate solutions.

Abstract: A liquid vitamin composition comprising (a) a first liquid vitamin formulation comprising vitamins A, D3, B12 and optionally vitamin E, (b) a second liquid vitamin formulation comprising vitamins B1, B2, B3, B5, B6, and H, and (c) a third liquid vitamin formulation comprising vitamin K3 wherein the three formulations are separate solutions.

Abstract: A process for the preparation of spherules and emulsions containing such spherules. A primary oil-in-water emulsion is formed containing particles comprising one or more active principles in oily form suspended in water, the water optionally containing at least one protein. Controlled division of the primary emulsion is achieved by combining the primary emulsion with a water-immiscible solvent to create a second emulsion containing spherules of the primary emulsion. Preferably, the particles of the primary emulsion have mean diameters of about 1 .mu.m, and preferably, the spherules contained in the second emulsion have a diameter ranging from 100 .mu.m to 500 .mu.m. If protein is contained in the primary emulsion, the protein can be cross-linked. Further, the spherules can be separated from the water-immiscible solvent.