Abstract: A device for tissue sampling that comprises a needle, a stylet and a sealing member. The needle comprises a distal tip, a proximal end, and one or more interior portions. The needle extends along a longitudinal axis extending between the distal tip and the proximal end. The stylet is moveably supported within the one or more interior portions of the needle. The sealing member Is moveably supported within the one or more interior portions of the needle and substantially conforms to the one or more interior portions, The distal tip is configured to obtain a tissue sample. The stylet and the sealing member are movable, along the longitudinal axis away from the distal tip so that a local vacuum is created at the distal tip so that obtained tissue samples can be aspirated into the needle.

Abstract: A method for controlling condensation of hydrogen peroxide at a preselected temperature within a sealed sterilization chamber including an article to be sterilized includes the steps of applying to the sealed chamber a vacuum of a first pressure sufficient to evaporate, at the preselected temperature, an aqueous solution of hydrogen peroxide of a first concentration. The hydrogen peroxide solution is then evaporated into a water vapor component and a hydrogen peroxide vapor component. The evaporated solution is injected into the sealed chamber in repeated pulses. The injecting is terminated once a preselected second pressure, higher than the first pressure, is reached in the chamber. The pulse volume is selected to allow selective control of the condensation of the hydrogen peroxide vapor component to achieve a layer of micro-condensation of hydrogen peroxide on the article, which layer has a second hydrogen peroxide concentration higher than the first hydrogen peroxide concentration.

Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain triazolo compounds (referred to herein as TAZ compounds), and especially certain [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-c]pyrimidine compounds, which, inter alia, inhibit AXL receptor tyrosine kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit AXL receptor tyrosine kinase function, and in the treatment of diseases and conditions that are mediated by AXL receptor tyrosine kinase, that are ameliorated by the inhibition of AXL receptor tyrosine kinase function, etc., including proliferative conditions such as cancer, etc.

Abstract: A motorization apparatus for a motorized wheel comprises an axle secured to a frame of a vehicle. A rotor unit has poles of magnet material. A stator unit having slots and teeth secured to the axle is inward of said rotor to define a clearance gap therewith such that the rotor unit is rotatable about the stator core. An arrangement of coils is wound around the teeth of the stator unit, the coils adapted to be powered to induce a rotation of the rotor unit relative to the stator unit. A structure comprises hub portions rotatably mounted to the axle, the structure having lateral walls defining an inner volume for the rotor unit and the stator unit, the structure supporting the rotor unit. The structure comprises attachment members connected to spokes of the motorized wheel, located radially inward of the clearance gap between the rotor unit and the stator unit.

Abstract: Devices and methods for occluding airways in at least one direction are disclosed. In some cases, the devices include anchoring mechanisms configured to keep an operative portion of the device (e.g., a valve) in position along a length of a lumen in which the device is deployed. The anchoring mechanisms can include anchors configured to settle into the lumen walls with little or no axial movement of the operative portion of the device. In some embodiments, the anchoring mechanisms include a secondary set of anchors configured to engage with the lumen wall to reduce, inhibit, or prevent axial movement of the operative portion of the device when the primary anchors settle into the walls of the lumen.

Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain triazolo compounds (referred to herein as TAZ compounds), and especially certain [1,2,4]triazolo[1,5-a]pyridine and [1,2,4]triazolo[1,5-c]pyrimidine compounds, which, inter alia, inhibit AXL receptor tyrosine kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit AXL receptor tyrosine kinase function, and in the treatment of diseases and conditions that are mediated by AXL receptor tyrosine kinase, that are ameliorated by the inhibition of AXL receptor tyrosine kinase function, etc., including proliferative conditions such as cancer, etc.

Abstract: The present invention is directed to compositions, uses and methods useful in the prevention or treatment of Candida infections, in particular Candida albicans infections and in particular recurrent Candida infections notably vaginal and oral or buccal candidiasis.

Abstract: A method of controlling unwanted condensation of hydrogen peroxide in a sterilization chamber at a preselected temperature is disclosed. The method includes the steps of maintaining the sterilization chamber at a vacuum pressure below the pressure at which hydrogen peroxide will boil at the preselected temperature, evaporating successive pulses of hydrogen peroxide, and injecting the evaporated hydrogen peroxide into the chamber, whereby the volume of each pulse of hydrogen peroxide is less than 75 ?L, preferably less than 35 ?L, most preferably less than 20 ?L. Sterilization results are improved by controlling unwanted condensation of hydrogen peroxide.