Patents by Inventor Jean Paul Reynes

Jean Paul Reynes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CPG-free gene for a new secreted reporter protein
    Patent number: 8435777
    Abstract: A synthetic gene devoid of CpG nucleotide derived by genetic engineering from copepod luciferases genes that code for a new secreted luciferase with a strong bioluminescent signal. This gene display advantageous properties to be used as a reporter genes in cell based assays.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: May 7, 2013
    Assignee: Cayla
    Inventors: Jean Paul Reynes, Céline Casteran, Daniel Drocourt, Gérard Tiraby
  • LYOPHILIZED PLASMID/DNA TRANSFECTION REAGENT CARRIER COMPLEX
    Publication number: 20110008894
    Abstract: Disclosed is a novel formulation for the production of a lyophilized plasmid/DNA transfection reagent complex capable of serving as a carrier for additional free plasmids. Upon rehydration, this plasmid/DNA transfection reagent carrier can be used to introduce simultaneously the complexed plasmid and the additional free plasmids into animal cells. This novel formulation can be useful for viral particle production, gene transfer experiments like gene silencing experiments, reporter gene, or integration/selection experiments.
    Type: Application
    Filed: July 6, 2010
    Publication date: January 13, 2011
    Applicant: CAYLA
    Inventors: Emmanuel RAVET, Fabienne VERNEJOUL, Jean-Paul REYNES, Daniel DROCOURT, Gérard TIRABY, Eric PEROUZEL
  • Synthetic genes and bacterial plasmids devoid of CpG
    Patent number: 7244609
    Abstract: The invention relates to a new series of bacterial plasmid vectors which are fully devoid of CpG and which can express synthetic genes which do not contain CpG in the bacteria Escherichia coli.
    Type: Grant
    Filed: March 11, 2002
    Date of Patent: July 17, 2007
    Assignee: Cayla
    Inventors: Daniel Drocourt, Jean Paul Reynes, Gerard Tiraby
  • Synthetic genes and bacterial plasmids devoid of cpg
    Publication number: 20040219677
    Abstract: The invention relates to a new series of bacterial plasmid vectors which are fully devoid of CpG and which can express synthetic genes which do not contain CpG in the bacteria Escherichia coli.
    Type: Application
    Filed: September 5, 2003
    Publication date: November 4, 2004
    Inventors: Daniel Drocourt, Jean Paul Reynes, Gerard Tiraby
  • Suicide genes and new associations of pyrimidine nucleobase and nucleoside analogs with new suicide genes for gene therapy of acquired diseases
    Patent number: 5856153
    Abstract: The present invention relates to two groups of suicide hybrid genes in which genes from one group specifically activate the pyrimidine nucleobase analog 5-fluorocytosine and genes from the other group activate the pyrimidine nucleoside analog azidothymidine to derivatives toxic for mammalian cells.The present invention further relates to methods for the selective killing of transfected tumor cells or immune cells using a single suicide hybrid gene or the combination of two suicide hybrid genes selected for a complementarity in their antimetabolic action. The present invention also relates to eukaryotic vectors comprising two expression suicide gene units, the first permitting the sensitization of tumor cells to 5-fluorocytosine and the second permitting the sensitization of HIV-infected cells to Azidothymidine in a synergistic fashion.
    Type: Grant
    Filed: November 17, 1994
    Date of Patent: January 5, 1999
    Assignee: Cayla
    Inventors: Gerard Tiraby, Jean-Paul Reynes, Michele Tiraby, Christophe Cazaux, Daniel Drocourt