Abstract: Use of a colloidal carrier for the manufacture of a medicament for inhibiting P-glycoprotein, wherein said colloidal carrier:—encapsulates or adsorbs a pharmacologically active substance, and—comprises P-glycoprotein inhibitor surfactants bound to the colloidal carrier surface.

Abstract: The present invention provides microspheres intended to be administered by injection comprising a protein active ingredient and an agent coating the active ingredient intended to prolong its release, wherein they are free of any trace of organic solvent and they can be obtained according to a coating method involving bringing the active ingredient and the coating agent into contact, with stirring, in a supercritical fluid, said coating agent being soluble in this supercritical fluid.

Abstract: Microparticles including a biodegradable, biocompatible material having at least a portion of surface adapted to adhere to cells of interest or fragments thereof; and at least one substance active on the cells or their environment upon implantation of the microparticles in a patient associated with the material wherein the substances is released in a controlled and/or extended manner.

Abstract: The invention relates to the use of biodegradable microspheres that release a radiosensitizing anticancer agent for producing a medicament to be used simultaneously with, separately from or spread over time with a radiotherapy, for treating glioblastoma. The use of said biodegradable microspheres according to the invention results in a patient survival time of least 90 weeks, a thereapeutically effective concentration being maintained in the parenchymatous area throughout this time. The microspheres used prefereably contain 5-fluorouracile of the tumor, by intratissular injection. The radiothereapy targeting the tumorous mass is dosed at 60 Gy over approximately 6 weeks. The invention also relates to a method for producing the biodegradable microspheres by emulsion-extraction, and to a suspension containing the biodegradable microspheres obtained using this method.

Abstract: Use of biodegradable microspheres releasing an anticancer agent for the manufacture of a medicament for the use in the treatment in humans of inoperable tumors, wherein biodegradable microspheres are administered by stereotactic injection directly into the tumor, into the peritumoral area or at the same time into the tumor and the peritumoral area.

Abstract: The invention concerns a novel method for preparing, by solvent extraction, PLGA/PLA-type polymer microspheres encapsulating water-soluble substances. The invention also concerns the microspheres obtained by said method.

Abstract: The present invention provides microspheres intended to be administered by injection comprising a protein active ingredient and an agent coating the active ingredient intended to prolong its release, wherein they are free of any trace of organic solvent and they can be obtained according to a coating method involving bringing the active ingredient and the coating agent into contact, with stirring, in a supercritical fluid, said coating agent being soluble in this supercritical fluid.

Abstract: The subject of the present invention is microspheres intended to be administered by injection, comprising a protein active ingredient and an agent coating the active ingredient intended to prolong its release, free of any trace of organic solvent and obtainable according to a coating method involving bringing the active ingredient and the coating agent into contact, with stirring, in a supercritical fluid, the said coating agent being soluble in the supercritical fluid. The protein active ingredient is not denatured.

Abstract: The invention relate to the use of biodegradable microspheres that release a radiosensitizing anticancer agent for producing a medicament to be used simultaneously with, separately from, or spread over time with a radiotherapy, for treating glioblastoma. The use of said biodegradable microspheres according to the invention results in a patient survival time of least 90 weeks, a therapeutically effective concentration being maintained in the parenchymatous area throughout this time. The microspheres use preferably contain 5-fluorouracile coated with poly(d-l-lactic acid-co-glycolic acid). The microspheres are implanted in the walls of the operation site following the exeresis of the tumor, by intratissular injection. The radiotherapy targeting the tumorous mass is dosed at 60 Gy over approximately 6 weeks. The invention also relates to a method for producing the biodegradable microspheres by emulsion-extraction, and to a suspension containing the biodegradable microspheres obtained using this method.

Abstract: The invention concerns nanocapsules, in particular with an average size less than 50 nm, consisting of an essentially lipid core liquid or semiliquid at room temperature, coated with an essentially lipid film solid at room temperature having a thickness of 2-10 nm. The invention also concerns a method for preparing same which consists in producing a reverse phase of an aqueous emulsion brought about by several temperature raising and lowering cycles. Said lipid nanocapsules are particularly designed for producing a medicine.

Abstract: The invention relates to a filament comprising thermoluminescent particles that are evenly distributed in a polymer matrix, characterized in that the polymer matrix is a thermoplastic polymer having sufficient adhesion with respect to said thermoluminescent particles in order to ensure the cohesion of said filament and being such that the thermoluminescent response (signal) of the filament corresponds substantially to the dose of radiation absorbed and obtained after the filament is placed in contact with a physiological medium. The invention also relates to a method for thermoluminescence-based measurement of doses of beta radiation delivered by a transmitter on a target organ of a mammal, characterized in that a group of inventive filaments is introduced to the desired spot, whereby part of the length of said filaments remains outside the irradiated area, and in that the filaments are removed after irradiation and thermoluminescence is determined.

Abstract: The invention concerns a hair and/or body care product for humans or animals, in the form of a powder having a granulometry of 30 to 500 microns, applicable directly to the wet hair and/or the body and comprising, percentages being expressed as percentages by weight relative to the total weight of the powder, less than 40% of at least one surfactant, and from 1 to 12% of at least one perfume, the percentage being made up to 100% by one or more products selected from the group consisting of sugars, starches, celluloses, polyols, proteins, amino acids, perfumes, colourings, antioxidants, plant substances, seaweed, vitamins, essential oils and mineral fillers.

Abstract: Methods of treatment in humans of inoperable tumors are disclosed. In particular, the disclosed method is useful for treatment of brains tumors, for example, glioblastomas, tumors of the otorhinolaryngologic sphere, rectal tumors, osseous, hepatic or brain metastasis and non-malignant cystic tumors such as craniopharyngiomas. In the method of treatment, biodegradabale microspheres which release an anticancer agent are administered by stereotactic injection directly into the tumor, into the peritumoral area or at the same time into the tumor and the peritumoral area.

Abstract: The invention relates to the use of biodegradable microspheres that release a radiosensitizing anticancer agent for producing a medicament to be used simultaneously with, separately from or spread over time with a radiotherapy, for treating glioblastoma. The use of said biodegradable microspheres according to the invention results in a patient survival time of least 90 weeks, a thereapeutically effective concentration being maintained in the parenchymatous area throughout this time. The microspheres used prefereably contain 5-fluorouracile of the tumor, by intratissular injection. The radiothereapy targeting the tumorous mass is dosed at 60 Gy over approximately 6 weeks. The invention also relates to a method for producing the biodegradable microspheres by emulsion-extraction, and to a suspension containing the biodegradable microspheres obtained using this method.

Abstract: The invention concerns a method for preparing microcapsules containing an active substance coated with a substantially polar polymer film, characterized in that it consists in the following steps: suspending an active substance insoluble in a substantially polar polymer solution in an organic solvent, said substantially polar polymer being insoluble in liquid or supercritical CO2, said organic solvent being soluble in liquid or supercritical CO2; contacting the suspension with liquid or supercritical CO2 so as to extract the solvent from the polymer in a controlled manner and ensure the coacervation of the polymer; substantially extracting the solvent by means of supercritical CO2 and draining off the CO2/solvent mixture; recuperating the microcapsules in the form of dry powder.

Abstract: A microparticle comprising an active substance which is a central core made of liquid, gaseous or solid particle of regular or irregular shape, and the method for entrapping said active substance in a coating material which is conformationally distributed on said active substance and has a thickness ranging from the thickness of a monomolecular layer to about 100 .mu.m. These compositions are useful for applications that require protection, prolonged release, taste masking, improved stability, altered handling behavior, altered surface properties including particle wettability, and other desirably altered properties.

Abstract: A single-dose solid composition useful for cleaning or treating human or animal hair and having a high disintegration rate in water is disclosed. The composition includes at least one surface active agent selected from the group consisting of an anionic surface active agent and a nonionic surface active agent, an amphoteric product and at least one disintegrating agent. The composition has a disintegration time in an aqueous medium selected from the group consisting of water and aqueous solutions of less than about 5 minutes. The disintegrating agent consists essentially of polyvinylpyrrolidone. A method for making said composition is also disclosed.