Abstract: The present invention relates to the field of medicine. It relates more particularly to a product suppressing or reducing the expression or activity of the human small nucleolar RNA (snoRNA) of sequence SEQ ID NO: 1 for use as a medicament. The product of the invention is preferably for use for preventing or treating cancer. The description further relates to vectors, cells, vehicles and compositions capable of delivering and expressing a product suppressing or reducing the expression or activity of the human small nucleolar RNA (snoRNA) of sequence SEQ ID NO: 1, and to uses thereof.

Abstract: The present invention concerns the use of particular RNA sequences as a medicament. More precisely, it concerns the use of small nucleolar RNAs (snoRNAs) which the inventor has shown to be involved in the mechanisms of aging. The snoRNAs of the invention can be used in particular to increase the stress resistance of a subject and to fight against the harmful effects of aging, typically for preventing or treating a degenerative disease, a laminopathy, diabetes, obesity or a cancer and, more generally, to prolong the lifespan of a subject. The snoRNAs of the invention can also be used in the treatment of infertility. The invention further relates to vectors, cells, transgenic animals and compositions capable of expressing an snoRNA of the invention, and methods using any of the above products of the invention as a tool for identification of a molecule active in the prevention or treatment of a pathology, abnormality or disorder linked to a mechanism of aging.

Abstract: The present invention concerns the use of particular RNA sequences as a medicament. More precisely, it concerns the use of small nucleolar RNAs (snoRNAs) which the inventors have shown to be involved in the mechanisms of aging. The snoRNAs of the invention can be used in particular to increase the stress resistance of a subject, to fight against the harmful effects of aging, typically for preventing or treating a degenerative disease, a laminopathy, diabetes, obesity or a cancer and, more generally, to prolong the lifespan of a subject. The snoRNAs of the invention can also be used in the treatment of infertility. The invention further relates to vectors, cells, transgenic animals and compositions capable of expressing a snoRNA of the invention, and methods using any of the above products of the invention as a tool for identification of a molecule active in the prevention or treatment of a pathology, abnormality or disorder linked to a mechanism of aging.

Abstract: The invention relates to a biochip comprising a substrate presenting a reflecting main surface and wherein the main surface presents localized sites that are made sensitive to fluorescence detection by a transparent layer having optical thickness (2k+1)?/4 where k is a positive or zero integer and where ? designates a wavelength lying between a wavelength ?0 at which fluorescence is excited and a wavelength ?1 at which fluorescence is emitted. The biochip can be manufactured by depositing a transparent layer of thickness m??/2 on a substrate and by making studs or wells of thickness (2k+1)?/4 in said layer to form said sensitive sites.

Abstract: A method of ex situ fabrication of at least one biochip, the method being of the type consisting in projecting onto a substrate a microvolume of reagent comprising at least one probe diluted in a suitable solvent so as to form, after the solvent has been eliminated, a spot comprising said probe, the method consisting in using a microprojection device comprising at least one tank in which the reagent is stored, and at least one source of gas under pressure put into communication with the tank, and in projecting the microvolume of reagent through an ejection nozzle under drive from the pressure exerted by the gas on the reagent.

Abstract: This invention concerns the use, for synthesizing and immobilising nucleic acids, of a solid support modified by an organized self-assembled monolayer of one or several organosilicon compounds. The invention also concerns methods for synthesizing and immobilizing nucleic acids on such a silanized solid support, and DNA chips obtained by said methods.

Abstract: A method of ex situ fabrication of at least one biochip, the method being of the type consisting in projecting onto a substrate a microvolume of reagent comprising at least one probe diluted in a suitable solvent so as to form, after the solvent has been eliminated, a spot comprising said probe, the method consisting in using a microprojection device comprising at least one tank in which the reagent is stored, and at least one source of gas under pressure put into communication with the tank, and in projecting the microvolume of reagent through an ejection nozzle under drive from the pressure exerted by the gas on the reagent.

Abstract: The invention relates to a biochip comprising a substrate presenting a reflecting main surface and wherein the main surface presents localized sites that are made sensitive to fluorescence detection by a transparent layer having optical thickness (2k+1)&lgr;/4 where k is a positive or zero integer and where &lgr; designates a wavelength lying between a wavelength &lgr;0 at which fluorescence is excited and a wavelength &lgr;1 at which fluorescence is emitted. The biochip can be manufactured by depositing a transparent layer of thickness m&lgr;′/2 on a substrate and by making studs or wells of thickness (2k+1)&lgr;/4 in said layer to form said sensitive sites.

Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essent

Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essent

Abstract: The invention concerns the use, for synthesising and immobilising nucleic acids, of a solid support modified by an organised self-assembled monolayer of one or several organosilicon compounds. The invention also concerns methods for synthesising and immobilising nucleic acids on such a silanized solid support, and DNA chips obtained by said methods.

Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essent

Abstract: An apparatus and method for identifying and/or quantifying a charged biological substance in a conductive liquid medium.

Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essent

Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essent

Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge- effect phenomenon directly and essen

Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essent