Patents by Inventor Jean-Robert Dormoy

Jean-Robert Dormoy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6946269
    Abstract: The invention relates to lower-alkyl esters of 3-(3,4-dihalophenyl)-2,6-dioxopiperidine-3-propionic acid derivatives, and to processes for preparing the same.
    Type: Grant
    Filed: December 4, 2003
    Date of Patent: September 20, 2005
    Assignee: Sanofi-Aventis
    Inventors: Bertrand Castro, Jean-Robert Dormoy, Alain Rabion
  • Publication number: 20040110796
    Abstract: The invention relates to lower-alkyl esters of 3-(3,4-dihalophenyl)-2,6-dioxopiperidine-3-propionic acid derivatives, and to processes for preparing the same.
    Type: Application
    Filed: December 4, 2003
    Publication date: June 10, 2004
    Inventors: Bertrand Castro, Jean-Robert Dormoy, Alain Rabion
  • Patent number: 6686182
    Abstract: The invention relates to lower-alkyl esters of 3-(3,4-dihalophenyl)-2,6-dioxopiperidine-3-propionic acid derivatives, and to processes for preparing the same.
    Type: Grant
    Filed: June 19, 2002
    Date of Patent: February 3, 2004
    Assignee: Sanofi-Synthelabo
    Inventors: Bertrand Castro, Jean-Robert Dormoy, Alain Rabion
  • Publication number: 20030032810
    Abstract: The invention relates to lower-alkyl esters of 3-(3,4-dihalophenyl)-2,6-dioxopiperidine-3-propionic acid derivatives, and to processes for preparing the same.
    Type: Application
    Filed: June 19, 2002
    Publication date: February 13, 2003
    Inventors: Bertrand Castro, Jean-Robert Dormoy, Alain Rabion
  • Patent number: 6469173
    Abstract: The invention relates to lower-alkyl esters of 3-(3,4-dihalophenyl)-2,6-dioxopiperidine-3-propionic acid derivatives, and to processes for preparing the same.
    Type: Grant
    Filed: June 12, 2001
    Date of Patent: October 22, 2002
    Assignee: Sanofi-Synthelabo
    Inventors: Bertrand Castro, Jean-Robert Dormoy, Alain Rabion
  • Patent number: 6417400
    Abstract: The present invention relates to: a) methylbiphenyl derivatives of general formula: in which R1 represents OH, C3-C7 alkyl or C3-C7 cycloalkyl, these compounds being in the form of individual isomers or mixtures thereof, b) their preparation by reaction: either of a hydroxylamine salt with an N-substituted o-(p-tolyl)benzaldimine, to give o-(p-tolyl)benzaldoxime or of an N-substituted 2-halobenzaldimine with a p-tolylmagnesium halide in the presence of an inorganic manganese derivative, to give the compounds of formula I in which R1 represents C3-C7 alkyl or C3-C7 cycloalkyl c) their use for the preparation of o-(p-tolyl)-benzonitrile, which is an intermediate in the synthesis of medicinal products.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: July 9, 2002
    Assignee: Sanofi-Synthelabo
    Inventors: Jean-Robert Dormoy, Dominique Goubet, Patrice Moreau
  • Patent number: 6407253
    Abstract: The subject-matter of the invention is a process for the preparation of substituted 4-methylbiphenyls of general formula: in which R is a cyano group or a protected tetrazolyl group of formula: in which R1, situated at the 1 or 2 position of the tetrazolyl group, is a protective group, characterized in that a halobenzene of formula: in which Hal is a halogen atom and R has the same meaning as above, is reacted with a p-tolylmagnesium halide in the presence of a linear or branched polyether and of a catalyst comprising a transition metal.
    Type: Grant
    Filed: July 14, 1999
    Date of Patent: June 18, 2002
    Assignee: Sanofi-Synthelabo
    Inventors: Mouad Alami, GĂ©rard Cahiez, Bertrand Castro, Jean-Robert Dormoy, Eric Riguet
  • Patent number: 6118025
    Abstract: The invention concerns a method for preparing an optically active alcohol of formula (I) in which the carbon atom indicated by the symbol * can have the configuration (R) or (S) and X represents a non-substituted amino group or a mono- or di-(C.sub.1 -C.sub.4)alkylamino group optionally salified from corresponding ketones by catalytic hydrogenation in the presence of a rhodium complex.
    Type: Grant
    Filed: December 27, 1999
    Date of Patent: September 12, 2000
    Assignee: Sanofi-Synthelabo
    Inventors: Francine Agbossou, Marc Devocelle, Jean-Robert Dormoy, Andre Mortreux
  • Patent number: 6080875
    Abstract: The present invention relates to a process for the preparation of 2-thienylethylamine derivatives of general formula: ##STR1## as well as their acid addition salts, in which R represents a halogen atom and R.sub.1 represents a C.sub.1 -C.sub.4 alkyl group, characterized in that a thienylglycidic derivative of general formula: ##STR2## in which M represents an alkali metal atom or a fraction of an alkaline-earth metal atom, is reacted with a phenylglycine ester, optionally in the form of a strong acid salt, of general formula: ##STR3## in which R and R.sub.1 have the same meaning as above, in the presence of an alkali metal borchydride of general formula:X--Y IVin which X represents an alkali metal atom and Y represents a group of formula:--BH.sub.3 CN or --BH.sub.(4-w) Z.sub.win which Z represents a carboxylic acid residue and optionally in the presence of a C.sub.1 -C.sub.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: June 27, 2000
    Assignee: Sanofi-Synthelabo
    Inventors: Bertrand Castro, Jean-Robert Dormoy, Aldo Previero
  • Patent number: 5420300
    Abstract: The subject of the invention is 2-(1-bromoethyl)benzo[b]thiophene of formula: ##STR1## as well as a process for the preparation thereof, characterised in that 2-ethylbenzo[b]thiophene is reacted, in a solvent, with a brominating agent in the presence of a free radical initiator, which provides the desired compound, and the use thereof in the preparation of 2-(1-(benzyloxyamino)ethyl)benzo[b]thiophene and of N-hydroxy-N-{1-(benzo[b]thien-2-yl)ethyl}urea.No figure.
    Type: Grant
    Filed: September 17, 1993
    Date of Patent: May 30, 1995
    Assignee: Elf Sanofi
    Inventor: Jean-Robert Dormoy
  • Patent number: 5081240
    Abstract: The object of the invention is a process for the preparation of the trans(-) (2R,3S) diastereoisomer of the glycidic esters of general formula: ##STR1## wherein a chlorohydrin of general formula: ##STR2## is reacted with a strong organic base in a suitable solvent and at a temperature between -10.degree. C. and room temperature.Another object of the invention is intermediate compounds cis(+) (2S,3S) 1,5-benzothiazepin-4-one.
    Type: Grant
    Filed: July 12, 1990
    Date of Patent: January 14, 1992
    Assignee: Sanofi
    Inventors: Andre Bousquet, Jean-Robert Dormoy, Alain Heymes
  • Patent number: 5079363
    Abstract: The subject of the present invention is a process for the preparation of isoquinoline derivatives in four steps wherein use is made as synthetic intermediates of organo-lithium compounds or related compounds.
    Type: Grant
    Filed: February 22, 1989
    Date of Patent: January 7, 1992
    Assignee: Sanofi
    Inventors: Michel Bouisset, Andre Bousquet, Jean-Robert Dormoy, Alain Heymes
  • Patent number: 5071985
    Abstract: The invention relates to a process for the preparation of morphinane derivatives of general formula: ##STR1## by demethylation of 3-methoxylated compound with a sulfonic acid selected from methanesulfonic acid and trifluoromethanesulfonic acid in the presence of a sulfide.
    Type: Grant
    Filed: September 12, 1989
    Date of Patent: December 10, 1991
    Assignee: Sanofi
    Inventors: Jean-Daniel Andre, Jean-Robert Dormoy, Alain Heymes
  • Patent number: 4831144
    Abstract: The invention relates to a process for fixing an electrophilic group in the 2-position of 1H-pyrrolo[3,2-c]pyridine N-protected in the 1-position, process which consists in protecting the 1-position in question with a labile protecting group, reacting the compound so obtained with a lithiation agent selected from a lithium amide and an alkyl lithium at a temperature between -80.degree. C. and -20.degree. C. and in the presence of tetramethylethylenediamine to obtain the corresponding 2-lithio derivative and then condensing the metal derivative so obtained at a temperature between -80.degree. C. and room-temperature with a reagent capable of giving rise to an electrophilic group to form N-protected 1H-pyrrolo[3,2-c]pyridine substituted in the 2-position by an electrophilic group.
    Type: Grant
    Filed: January 7, 1988
    Date of Patent: May 16, 1989
    Assignee: SANOFI
    Inventors: Jean-Robert Dormoy, Alain Heymes
  • Patent number: 4625033
    Abstract: A process for preparing 1H-pyrrolo-[3,2-c]-pyridine or 5-aza-indole in high yield, comprising condensing 3-methyl-4-nitropyridine-1-oxide with a compound having a formula ##STR1## wherein R represents a di-loweralkylamino, morpholino, piperidino or pyrrolidino group and R.sub.1 and R.sub.2, which are the same or different, each represent a loweralkoxy group or a group R as defined; to form an enamine having a formula: ##STR2## wherein R is as define and subjecting the enamine IV to reduction cyclization; the enamines IV are new compounds.
    Type: Grant
    Filed: May 28, 1985
    Date of Patent: November 25, 1986
    Assignee: Sanofi
    Inventors: Jean-Robert Dormoy, Alain Heymes