Patents by Inventor Jean-Stephane Joly

Jean-Stephane Joly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In-vitro method for producing oocytes or eggs having targeted genomic modification
    Publication number: 20080113437
    Abstract: The invention relates to an in vitro method for introducing a targeted genome modification into an oocyte or an egg and a method for performing a random insertion in the genome of a host cell.
    Type: Application
    Filed: June 14, 2007
    Publication date: May 15, 2008
    Applicant: Institut National de la Recherche Agronomique-INRA
    Inventors: Jean-Stephane Joly, Violette Thermes, Frederic Sohm
  • Random integration of a polynucleotide by in vivo linearization
    Patent number: 7098031
    Abstract: The present invention concerns a method for in vivo generation of a linear polynucleotide with 5? and 3? free ends from a vector having no free end, said linear polynucleotide being integrated into the host cell genome. The vector having no free end according to the present invention comprise the polynucleotide to be linearized or excised flanked by a cleavage site, said cleavage site being preferably not found in the host cell genome. The present invention also relates to the resulting cells and their uses, for example for production of proteins or other genes, biomolecules, biomaterials, transgenic plants, vaccines, transgenic animals or for treatment or prophylaxis of a condition or disorder in an individual.
    Type: Grant
    Filed: September 13, 2002
    Date of Patent: August 29, 2006
    Assignee: Cellectis SA
    Inventors: Andre Choulika, Jean-Stephane Joly, Violette Thermes, Filomena Ristoratore
  • Random integration of a polynucleotide by in vivo linearization
    Publication number: 20030106077
    Abstract: The present invention concerns a method for in vivo generation of a linear polynucleotide with 5′ and 3′ free ends from a vector having no free end, said linear polynucleotide being integrated into the host cell genome. The vector having no free end according to the present invention comprise the polynucleotide to be linearized or excised flanked by a cleavage site, said cleavage site being preferably not found in the host cell genome. The present invention also relates to the resulting cells and their uses, for example for production of proteins or other genes, biomolecules, biomaterials, transgenic plants, vaccines, transgenic animals or for treatment or prophylaxis of a condition or disorder in an individual.
    Type: Application
    Filed: September 13, 2002
    Publication date: June 5, 2003
    Inventors: Andre Choulika, Jean-Stephane Joly, Violette Thermes, Filomena Ristoratore