Abstract: The present invention includes composition, methods of making and methods of using a multi-nano-well plate having a first layer at least partially disposed on the substrate and one or more nano-wells that extends through the first layer that extends toward the substrate, wherein the one or more nano-wells having an opening in the first layer connected to bottom layer by one or more walls.

Abstract: The present invention includes micro-sphere composition, methods of making binding assays. The present invention also includes a micro-sphere for binding biological molecules without pretreatment. The micro-sphere includes a spherical glass substrate having one or more metal nanoparticle regions that are exposed from within the glass, wherein the micro-sphere is capable of binding biological molecules without pretreatment.

Abstract: The present invention provides a method of forming one or more biological-binding areas on a substrate for biological-testing. The method includes activating at least a portion of a glass-ceramic substrate comprising glass and one or more metal containing compounds. The one or more metal containing compounds have a range of diameters that are less than about 300 nanometers in diameter and are spaced an average distance of at least one-half the midpoint of the diameter range apart. The one or more metals include compounds selected from metal oxides, metal nanoparticles, metal alloys, and atomic metals. The glass-ceramic substrate is heated to a temperature near the glass transformation temperature to form one or more metal nanoparticles in one or more ceramic biological-binding areas. The glass-ceramic substrate is etched to expose one or more metal.

Abstract: This invention provides an inexpensive and rapid method for fabricating a high-anisotropic-etch ratio, shaped glass structures using a novel photosensitive glass composition. Structures of the photosensitive glass may include micro-channels, micro-optics, microposts, or arrays of hollow micro-needles. Furthermore, such shaped glass structures can be used to form a negative mold for casting the shape in other materials.

Abstract: This invention provides an inexpensive and rapid method for fabricating a high-anisotropic-etch ratio, shaped glass structures using a novel photosensitive glass composition. Structures of the photosensitive glass may include micro-channels, micro-optics, microposts, or arrays of hollow micro-needles. Furthermore, such shaped glass structures can be used to form a negative mold for casting the shape in other materials.