Abstract: Provided herein are compounds binding to KRAS protein or a mutant thereof, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

Abstract: A locking mechanism (100) includes one or more casters (102,103,104,105) coupled to a frame (101). A lift mechanism (106,107) is distally extendable from the frame to elevate the casters. A pivoting bar (108) is pivotable relative to the frame to distally extend the lift mechanism from the frame. A foot pedal (113) is pivotable relative to the pivoting bar between a closed position and an angularly displaced open position. When in the angularly displaced open position, the foot pedal can extend distally from the pivoting bar.

Abstract: A bend restrictor device includes at least two bend limiter units coupled together and having at least one stiffness ring disposed therebetween.

Abstract: A locking mechanism (100) includes one or more casters (102,103,104,105) coupled to a frame (101). A lift mechanism (106,107) is distally extendable from the frame to elevate the casters. A pivoting bar (108) is pivotable relative to the frame to distally extend the lift mechanism from the frame. A foot pedal (113) is pivotable relative to the pivoting bar between a closed position and an angularly displaced open position. When in the angularly displaced open position, the foot pedal can extend distally from the pivoting bar.

Abstract: Recovery determination methods and recovery determination apparatuses are described. According to one aspect, a recovery determination method includes accessing an input for a recovery marker which corresponds to a characteristic of an individual, wherein the input comprises data pertinent to the individual for the recovery marker while the individual is at rest following a period of exercise by the individual, processing the data of the individual for the recovery marker, and determining recovery information which is indicative of a state of recovery of the individual using the processing.

Abstract: Recovery determination methods and recovery determination apparatuses are described. According to one aspect, a recovery determination method includes accessing an input for a recovery marker which corresponds to a characteristic of an individual, wherein the input comprises data pertinent to the individual for the recovery marker while the individual is at rest following a period of exercise by the individual, processing the data of the individual for the recovery marker, and determining recovery information which is indicative of a state of recovery of the individual using the processing.

Abstract: A bend restrictor device includes at least two bend limiter units coupled together and having at least one stiffness ring disposed therebetween.

Abstract: Recovery determination methods and recovery determination apparatuses are described. According to one aspect, a recovery determination method includes accessing an input for a recovery marker which corresponds to a characteristic of an individual, wherein the input comprises data pertinent to the individual for the recovery marker while the individual is at rest following a period of exercise by the individual, processing the data of the individual for the recovery marker, and determining recovery information which is indicative of a state of recovery of the individual using the processing.

Abstract: A method for tightening a pipe coupler includes the steps of attaching a first end of the pipe coupler to a pipe, attaching an adapter to a second end of the pipe coupler, attaching an air gun to the adapter, tightening the pipe coupler by operating the air gun, and, after the tightening, removing the adapter from the pipe coupler. Threaded portions of the pipe and the pipe coupler are tapered, while the threaded portion of the adapter is not tapered. In an alternate embodiment, the adapter comprises a baffle and a ball on an inner surface.

Abstract: A two-wheeled hoppered cart is particularly adapted to receive crop from a combine and transfer same to another transport vehicle with an unloading conveyor, and to conveniently transport products to an air-seeder cart. The frame comprises a rear frame portion supporting the hoppered container, and a front frame portion extending forward and down from the rear frame portion to a hitch. A port with a gate is located below the rear frame, and a pair of wheels is mounted on the frame such that the rotational axis is located below the rear frame portion and rearward of the port. An access area below the port, ahead of the port, and to the first side of the port, is unobstructed. An intake hopper of a conventional air-seeder cart filling conveyor can be positioned under the port with the filling conveyor in front of the wheel on the first side of the cart.

Abstract: A two-wheeled hoppered cart is particularly adapted to receive crop from a combine and transfer same to another transport vehicle with an unloading conveyor, and to conveniently transport products to an air-seeder cart. The frame comprises a rear frame portion supporting the hoppered container, and a front frame portion extending forward and down from the rear frame portion to a hitch. A port with a gate is located below the rear frame, and a pair of wheels is mounted on the frame such that the rotational axis is located below the rear frame portion and rearward of the port. An access area below the port, ahead of the port, and to the first side of the port, is unobstructed. An intake hopper of a conventional air-seeder cart filling conveyor can be positioned under the port with the filling conveyor in front of the wheel on the first side of the cart.

Abstract: A method and system for the data entry of bar code data into computer programs that are designed to accept bar code data (reader application programs) and for the data entry of bar code data into computer programs that are not designed to accept bar code data (non-reader application programs) is provided. The bar code data is entered as a contiguous stream of characters, rather than one character at a time, so that lengthy bar code data strings will not be corrupted. Additionally, the method and system of the present invention provide for two-way communication between bar code-reading and processing services and a reader application program so that the reader application program may, among other things, reconfigure the bar code-reading reading and processing services.