Abstract: A system for performing a medical procedure in the intestine of a patient comprises a catheter for insertion into the intestine, a console, and a connector configured to operably attach the catheter to the console. The catheter comprises a shaft including a distal portion, and a functional assembly positioned on the distal portion of the shaft. The functional assembly is configured to receive fluid. The console comprises: a fluid reservoir configured to supply the fluid, a first syringe pump assembly configured to deliver the fluid to the functional assembly, a second syringe pump assembly configured to deliver the fluid to the functional assembly, a fluid heater configured to heat the fluid, and a waste fluid reservoir configured to receive the fluid. The system is configured to treat target tissue of the intestine of the patient. Methods of treating target tissue are also provided.

Abstract: A system for ablating surface tissue of a patient is provided. The system includes a console and an ablation catheter fluidly attached to the console. The console includes an ablative fluid supply, a neutralizing fluid supply, an injectate fluid supply, a pump assembly, and a vacuum supply. The ablation catheter includes an expandable functional assembly, a tissue expansion subsystem for expanding sub-surface tissue in the intestine of the patient, and a tissue ablation subsystem for ablating surface tissue in the intestine of the patient. Methods of ablating surface tissue are also provided.