Patents by Inventor Jeff Zhu

Jeff Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and system for syntactic searching
    Patent number: 11941033
    Abstract: The disclosure is directed at a method and system for improved search functionality. By using natural language processing (NLP), individual words in a search term may be parsed and then individually stored. The relationships between the individual words of the search term may also be stored such that when the search is repeated, the previous results may be retrieved and, if not, a more accurate search may be performed.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: March 26, 2024
    Assignee: Affirm, Inc.
    Inventors: Qi Zhu, Sean Weisman, Gregory Ward, Alishan Ladhani, Jeff Li
  • DISTRIBUTED-MEMORY PARALLEL PROCESSING OF FINITE ELEMENTS BASED ON CONTACT PAIR SPLITTING
    Publication number: 20240086582
    Abstract: Methods for modeling contact pairs in a model of a physical object include generating a contact pair including a contact surface and a target surface, where the contact pair further includes contact elements of the contact surface and the target surface, splitting the contact pair into contact sub-pairs along splitting boundaries, augmenting each contact sub-pair with contact elements from adjacent contact sub-pairs at the splitting boundaries, distributing the augmented contact sub-pairs to a plurality of parallel processors for finite element solutions of the contact sub-pairs, receiving the finite element solutions of the contact sub-pairs from the plurality of parallel processors, and combining the finite element solutions of the contact sub-pairs into finite element solutions of the contact pair.
    Type: Application
    Filed: September 18, 2023
    Publication date: March 14, 2024
    Inventors: Yongyi ZHU, Yong-Cheng Liu, Jeff Beisheim, Grama Bhashyam
  • UPGRADING REPLICATED DATABASES WITH SMALL DOWNTIME
    Publication number: 20210286824
    Abstract: An online system performs upgrades of replicated databases. The online system stores data in a primary site and a secondary site. The primary site comprising databases used to process client requests and a secondary site comprising databases used as standby. The online system upgrades databases of both sites by upgrading the secondary site, switching client requests to the secondary site while using the databases of primary site as standby databases. The online system then upgrades the primary site. The process allows the online system to upgrade databases with small down time.
    Type: Application
    Filed: May 21, 2020
    Publication date: September 16, 2021
    Inventors: Sheng Qiao, Zhaohui George Yao, Kim S. Lee, Abhishek Chaturvedi, Jeff Zhu, Mukesh Burgupalli
  • Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors
    Patent number: 8377983
    Abstract: The present invention relates to compounds and methods from the treatment of cancer. The invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising compounds that inhibit Aurora kinase, and methods for the treatment of cancer using the compounds of the presentation invention or pharmaceutical compositions comprising compounds of the present invention.
    Type: Grant
    Filed: February 10, 2010
    Date of Patent: February 19, 2013
    Assignee: TransTech Pharma, Inc.
    Inventors: Adnan M. M. Mjalli, Brian S. Grella, Govindan Subramanian, Murty N. Arimilli, Ramesh Gopalaswamy, Robert C. Andrews, Stephen Davis, Xiaochuan Guo, Jeff Zhu
  • Intermediates and methods for making zearalenone macrolide analogs
    Patent number: 8350059
    Abstract: Disclosed herein are methods and intermediates useful in the preparation of macrolides, e.g., compounds of formula (IV) wherein R1-R12 are as defined herein.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: January 8, 2013
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Roch Boivin, Silvio A. Campagna, Hong Du, Francis G. Fang, Thomas Horstmann, Charles-Andre Lemelin, Jing Li, Pamela McGuinness, Xiang Niu, Matthew J. Schnaderbeck, Kevin (kuo-ming) Wu, Xiaojie (jeff) Zhu
  • INTERMEDIATES AND METHODS FOR MAKING ZEARALENONE MACROLIDE ANALOGS
    Publication number: 20110237805
    Abstract: Disclosed herein are methods and intermediates useful in the preparation of macrolides, e.g., compounds of formula (IV) wherein R1-R12 are as defined herein.
    Type: Application
    Filed: December 8, 2008
    Publication date: September 29, 2011
    Applicant: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Roch Boivin, Silvio A. Campagna, Hong Du, Francis G. Fang, Thomas Horstmann, Charles-Andre Lemelin, Jing Li, Pamela Mcguinness, Xiang Niu, Matthew J. Schnaderbeck, Kevin (kuo-ming) Wu, Xiaojie (Jeff) Zhu
  • Benzazole Derivatives, Compositions, and Methods of Use as B-Secretase Inhibitors
    Publication number: 20110065713
    Abstract: The present invention is directed to benzazole compounds that inhibit ?-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.
    Type: Application
    Filed: November 19, 2010
    Publication date: March 17, 2011
    Applicant: High Point Pharmaceuticals, LLC
    Inventors: Adnan M.M. Mjalli, David Jones, Devi Reddy Gohimmukkula, Guoxiang Huang, Jeff Zhu, Mohan Rao, Robert C. Andrews, Tan Ren
  • Benzazole derivatives, compositions, and methods of use as ?-secretase inhibitors
    Patent number: 7893267
    Abstract: The present invention is directed to benzazole compounds that inhibit ?-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.
    Type: Grant
    Filed: March 14, 2006
    Date of Patent: February 22, 2011
    Assignee: High Point Pharmaceuticals, LLC
    Inventors: Adnan M. M. Mjalli, David Jones, Devi Reddy Gohimmukkula, Guoxiang Huang, Jeff Zhu, Mohan Rao, Robert C. Andrews, Tan Ren
  • Substituted heteroaryl derivatives, compositions, and methods of use
    Patent number: 7820704
    Abstract: The present invention provides substituted heteroaryl derivatives of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I), and methods of use in treating human or animal disorders. The compounds of the invention can be useful as inhibitors of action of AgRP on a melanocortin receptor and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.
    Type: Grant
    Filed: April 20, 2005
    Date of Patent: October 26, 2010
    Assignee: TransTech Pharma, Inc.
    Inventors: Adnan M. M. Mjalli, Bapu R. Gaddam, Ghassan Qabaja, Govindan Subramanian, Jeff Zhu, John Dankwardt, Murty N. Arimilli, Robert C. Andrews, Samuel Victory, Ye E. Tian
  • Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors
    Patent number: 7820821
    Abstract: The present invention relates to compounds and methods from the treatment of cancer. The invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising compounds that inhibit Aurora kinase, and methods for the treatment of cancer using the compounds of the presentation invention or pharmaceutical compositions comprising compounds of the present invention.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: October 26, 2010
    Assignee: TransTech Pharma, Inc.
    Inventors: Adnan M. M. Mjalli, Brian S. Grella, Govindan Subramanian, Murty N. Arimilli, Ramesh Gopalaswamy, Robert C. Andrews, Stephen Davis, Xiaochuan Guo, Jeff Zhu
  • Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors
    Patent number: 7763726
    Abstract: The present invention relates to compounds and methods from the treatment of cancer. The invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising compounds that inhibit Aurora kinase, and methods for the treatment of cancer using the compounds of the presentation invention or pharmaceutical compositions comprising compounds of the present invention.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: July 27, 2010
    Assignee: TransTech Pharma, Inc.
    Inventors: Adnan M. M. Mjalli, Brian S. Grella, Govindan Subramanian, Murty N. Arimilli, Ramesh Gopalaswamy, Robert C. Andrews, Stephen Davis, Xiaochuan Guo, Jeff Zhu
  • Benzazole Derivatives, Compositions, And Methods Of Use As Aurora Kinase Inhibitors
    Publication number: 20100152170
    Abstract: The present invention relates to compounds and methods from the treatment of cancer. The invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising compounds that inhibit Aurora kinase, and methods for the treatment of cancer using the compounds of the presentation invention or pharmaceutical compositions comprising compounds of the present invention.
    Type: Application
    Filed: February 10, 2010
    Publication date: June 17, 2010
    Applicant: TransTech Pharma, Inc.
    Inventors: Adnan M.M. Mjalli, Brian S. Grella, Govindan Subramanian, Murty N. Arimilli, Ramesh Gopalaswamy, Robert C. Andrews, Stephen Davis, Xiaochuan Guo, Jeff Zhu
  • Luminacin analogs and uses thereof
    Patent number: 7642284
    Abstract: The present invention provides compounds having formula (I) (and pharmaceutically acceptable derivatives thereof): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R14 and n are as defined herein.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: January 5, 2010
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Frank Fang, Charles Johannes, Ye Yao, Xiaojie (Jeff) Zhu
  • Benzazole Derivatives, Compositions, and Methods of Use as Beta-Secretase Inhibitors
    Publication number: 20090326006
    Abstract: The present invention is directed to benzazole compounds that inhibit ?-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.
    Type: Application
    Filed: March 14, 2006
    Publication date: December 31, 2009
    Inventors: Adnan M.M. Mjalli, David Jones, Devi Reddy Gohmmukkula, Guoxiang Huang, Jeff Zhu, Mohan Rao, Robert C. Andrews, Tan Ren
  • Luminacin analogs and uses thereof
    Publication number: 20080249320
    Abstract: The present invention provides compounds having formula (I) (and pharmaceutically acceptable derivatives thereof): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R14 and n are as defined herein.
    Type: Application
    Filed: April 9, 2008
    Publication date: October 9, 2008
    Inventors: Francis Fang, Charles Johannes, Ye Yao, Xiaojie (Jeff) Zhu
  • ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF
    Publication number: 20080070911
    Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
    Type: Application
    Filed: November 21, 2007
    Publication date: March 20, 2008
    Applicant: CARDIOME PHARMA CORP.
    Inventors: Allen Bain, Gregory Beatch, Cindy Longley, Bertrand Plouvier, Tao Sheng, Michael Walker, Richard Wall, Sandro Yong, Jeff Zhu, Alexander Zolotoy
  • ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF
    Publication number: 20080004333
    Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
    Type: Application
    Filed: June 4, 2007
    Publication date: January 3, 2008
    Applicant: CARDIOME PHARMA CORP.
    Inventors: Gregory Beatch, Bertrand Plouvier, Tao Sheng, Michael Walker, Richard Wall, Sandro Yong, Jeff Zhu, Alexander Zolotoy
  • AMINOCYCLOHEXYL ETHER COMPOUNDS AND USES THEREOF
    Publication number: 20070254945
    Abstract: Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.
    Type: Application
    Filed: March 23, 2007
    Publication date: November 1, 2007
    Applicant: CARDIOME PHARMA CORP.
    Inventors: Grace Jung, Bertrand Plouvier, Yuzhong Liu, Jeff Zhu, Tao Sheng, Anthony Barrett, Lewis Choi, Doug Chou
  • Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors
    Publication number: 20070219235
    Abstract: The present invention relates to compounds and methods from the treatment of cancer. The invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising compounds that inhibit Aurora kinase, and methods for the treatment of cancer using the compounds of the presentation invention or pharmaceutical compositions comprising compounds of the present invention.
    Type: Application
    Filed: February 9, 2007
    Publication date: September 20, 2007
    Inventors: Adnan Mjalli, Brian Grella, Govindan Subramanian, Murty Arimilli, Ramesh Gopalaswamy, Robert Andrews, Stephen Davis, Xiaochuan Guo, Jeff Zhu
  • Aminocyclohexyl ether compounds and uses thereof
    Publication number: 20070197632
    Abstract: Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.
    Type: Application
    Filed: August 11, 2005
    Publication date: August 23, 2007
    Applicant: Cardiome Pharma Corp
    Inventors: Gregory Beatch, Bertrand Plouvier, Tao Sheng, Michael Walker, Richard Wall, Sandro Yong, Jeff Zhu, Alexander Zolotoy