Patents by Inventor Jeffrey A. Mattis

Jeffrey A. Mattis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for labeling antibodies with a metal ion
    Patent number: 5177192
    Abstract: Methods for rapidly labeling sulfhydryl-containing antibodies or fragments with technetium or rhenium radioisotopes are disclosed. The method generally involves combining an aqueous mixture of the radiometal in an oxidized form, a reducing agent and a water-soluble polyhydroxycarbonylic acid ligand to form a stable complex of the radiometal in its reduced state and contacting the mixture with the sulfhydryl-containing antibody or fragment to produce a radiometal-labeled antibody or fragment.
    Type: Grant
    Filed: October 19, 1990
    Date of Patent: January 5, 1993
    Assignee: Centocor, Incorporated
    Inventors: Koon Y. Pak, Richard T. Dean, Jeffrey A. Mattis
  • Radiotherapeutic immunoconjugates labeled with iodine-125
    Patent number: 5130116
    Abstract: A radiotherapeutic immunoconjugate comprising a tumor specific monoclonal antibody, or fragment thereof, and an Auger electron emitting radionuclide, wherein the tumor specific monoclonal antibody or fragment is capable of tumor nucleus localization of the radionuclide and method of using it is disclosed. The radiotherapeutic immunoconjugate is administered in a therapeutically effective amount to patients having or suspected of having a malignancy reactive with the antibody or fragment.
    Type: Grant
    Filed: May 29, 1990
    Date of Patent: July 14, 1992
    Assignee: Centocor, Inc.
    Inventors: David V. Woo, Zenon Steplewski, Jeffrey A. Mattis
  • Method for labeling antibodies with a metal ion
    Patent number: 5053493
    Abstract: A simple, rapid and efficient method for labelling sulfhydryl-containing antibodies or antibody fragments with Tc-99m, Rh-186, Rh-188, Rh-189 or Rh-191 is disclosed. Labeled antibodies produced by the method are useful for radio-immunodiagnostic and/or radio-therapeutic purposes.
    Type: Grant
    Filed: April 2, 1987
    Date of Patent: October 1, 1991
    Assignee: Centocor Cardiovascular Imaging Partners, L.P.
    Inventors: Koon Y. Pak, Richard T. Dean, Jeffrey A. Mattis