Abstract: A composition for inhibiting ketohexokinase, for example, ketohexokinase-C (KHK-C) activity, may include a plant extract exhibiting at least IC50 (i.e., 50% KHK-C inhibition at a concentration in the range of from about 0.1 ?g/mL to about 1000 ?g/mL. The composition may be in a form suitable for oral ingestion. A method for inhibiting KHK-C activity in a subject may include administering a plant extract that exhibits at least 50% KHK-C inhibition at a concentration from about 0.1 ?g/mL to about 1000 ?g/mL. The administering may be done to treat or prevent at least one of sugar addiction, obesity, or metabolic syndrome. The administering may be done to provide a diminished craving in the subject from at least one member selected from the group consisting of craving of sugar, fructose, fructose-containing sugars, carbohydrates, and combinations thereof. The subject may be pre-diabetic, diabetic and or insulin resistant.

Abstract: A topical composition includes an alcohol-extracted Salvia hispanica seed extract in a glycol carrier in an amount effective for inhibiting melanin content in an individual. The extract may be extracted in a C1-C4 ethanol and re-suspended in a glycol carrier with one or more permeation enhancers. The topical composition may further include a Punica granatum extract. Methods for making and using the composition for whitening skin in an individual are also described.

Abstract: A surface cleaning apparatus includes a housing with an on-board hydrogen peroxide generator which produces a hydrogen peroxide solution in situ from fluid stored within an on-board supply tank of the surface cleaning apparatus, and further delivers the generated hydrogen peroxide solution to a cleaning pad attached to the housing of the surface cleaning apparatus.

Abstract: An autonomous floor cleaner includes a base that is movable over a surface to be cleaned, a collection chamber associated with the base, and a rotating top mounted coupled with the base for rotation relative to the base, where the top carries at least one sweeping element for sweeping dirt on the surface to be cleaned toward the collection chamber.

Abstract: A surface cleaning apparatus comprises a supply tank and a distributor for delivering fluid to a surface to be cleaned. A constant flow of fluid can be delivered from the supply tank to the distributor via a regulator tank in fluid communication with the supply tank for exchanging liquid and air with the supply tank.

Abstract: A topical composition includes an alcohol-extracted Salvia hispanica seed extract in a glycol carrier in an amount effective for inhibiting melanin content in an individual. The extract may be extracted in a C1-C4 ethanol and re-suspended in a glycol carrier with one or more permeation enhancers. The topical composition may further include a Punica granatum extract. Methods for making and using the composition for whitening skin in an individual are also described.

Abstract: A supplement including a blend of turmeric, quercetin and rosemary, or holy basil, wasabi, and broccoli seed extract which are present in a balanced and predetermined ratio, and which stimulate the Antioxidant Response Element (ARE), Quinone Reductase, and/or induce related gene expression, for example, heme oxygenase-1 (HMOX-1) expression. The blend of ingredients can be formed as or in a dietary supplement adapted for administration to a subject. The dietary supplement can be formulated so that the turmeric, quercetin and rosemary are present in a predetermined ratio of 1:3:5, or holy basil, wasabi, and broccoli seed extract in a predetermined ratio of 1:1:0.2. Additional ingredients can be included in the supplement. The supplement can synergistically affect natural antioxidant response pathways within cells of a subject to whom the supplement is administered. A related method of use is also provided.

Abstract: A topical composition includes an alcohol-extracted Salvia hispanica seed extract in a glycol carrier in an amount effective for inhibiting melanin content in an individual. The extract may be extracted in a C1-C4 ethanol and resuspended in a glycol carrier with one or more permeation enhancers. The topical composition may further include a Punica granatum extract. Methods for making and using the composition for whitening skin in an individual are also described.

Abstract: A surface cleaning apparatus, and in particular a steam mop, comprises a steam generator and a cleaning pad. Steam from the steam generator can be applied to a cleaning composition applied to a stain on a floor surface. The cleaning composition can be applied directly to the floor surface, or indirectly via the cleaning pad.

Abstract: A topical cosmetic composition for skin whitening or skin lightening is described. The composition includes an aqueous extract of Caesalpinia spinosa, also known as Tara, in an amount effective to reduce melanin production. The composition may also include an extract of Centella asiatica, also known as Gotu Kola. A method for using the compositions is also described.

Abstract: A surface cleaning apparatus (10) comprises a base assembly (12), an upright handle assembly (14) pivotally mounted to the base assembly (12), a fluid distribution system including a supply of cleaning fluid, and a fluid recovery system for drawing dirty cleaning fluid from the surface to be cleaned. The base assembly (12) comprises a fluid supply tank (22) mounted on a base platform (20), and a recovery tank (24) and lid (70) mounted on the supply tank (22). The nozzle (146) assembly is split into three separable sections, and the upper handle (300) is foldable to a storage position. The base assembly (12) further comprises a pivotal brush carriage (210) assembly. A method for renting extraction cleaning machines (10) utilizes a vending machine (600) that dispenses cleaning formulations packaged in single use packages (602).

Abstract: A vacuum cleaner with a separation module comprises an exhaust grill positioned fluidly between a separator chamber and an air outlet. The exhaust grill can comprise a body having a plurality of louvers and a plurality of inlets defined between adjacent louvers.

Abstract: A mist generating system for a cleaning implement is adapted to generate a finely atomized liquid mist for suppressing dust, allergens, and other airborne particulates. The mist generating system can be adapted to fit many cleaning implements such as vacuum cleaners, wet extraction cleaners, floor mops, and dusters to suppress airborne dust and particulates generated during operation and the cleaning process.

Abstract: A cleaning cloth for use with a steam mop having a housing mounting the cleaning cloth for cleaning the surface to be cleaned and a steam delivery system for delivering steam to the cleaning cloth. The cleaning cloth has at least one fabric layer that is configured to be attached to a steam mop and an encapsulated cleaning composition associated with the fabric layer and configured to be released by exposure to steam delivered to the cleaning cloth. A steam mop for use of the cleaning cloth and a method of cleaning with the cleaning pad is also disclosed.

Abstract: A topical composition includes an alcohol-extracted Salvia hispanica seed extract in a glycol carrier in an amount effective for inhibiting melanin content in an individual. The extract may be extracted in a C1-C4 ethanol and resuspended in a glycol carrier with one or more permeation enhancers. The topical composition may further include a Punica granatum extract. Methods for making and using the composition for whitening skin in an individual are also described.

Abstract: The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.

Abstract: The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.

Abstract: Method of making an alpha-amino acid compound having the structure of Formula 32: comprising treating under hydrolyzing conditions a hydantoin compound having the structure of Formula 33: where the substituents are described herein.

Abstract: The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.

Abstract: The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.