Abstract: The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: Methods and systems to prevent adverse exchange limit effects are disclosed. An example method of message management includes tracking, at a gateway, a transaction count of trade messages communicated to an exchange via an exchange link. The example method includes defining a first transaction limit based on the transaction count, and calculating a second transaction limit as a function of the first transaction limit, wherein the second transaction limit is to correspond to a reserve capacity associated with the exchange link. The example method includes assigning a message priority to each of a plurality of trade messages to communicate to the exchange. The example method includes communicating trade messages of the plurality of trade messages having a first message priority to the exchange when the transaction count is greater than the second transaction limit, and delaying or rejecting trade messages of the plurality of trade messages having a second message priority.

Abstract: A self-powered vehicle comprises a mechanical drive system, a set of sensors, and a controller coupled to the mechanical drive system to move the vehicle. The self-powered vehicle can operate in a plurality of modes, including a training mode and a smart behavior mode. In the training mode, the vehicle follows a trajectory of a user, and stores the trajectory in memory. In the smart behavior mode the vehicle autonomously traverses the stored trajectory.

Abstract: It relates to a pharmaceutical combination comprising a KRAS G12C inhibitor, in particular 1-{6-[(4M)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro [3.3] heptan-2-yl} prop-2-en-1-one (Compound A) and one or more therapeutically active agents selected from a SHP2 inhibitor (e.g. TNO155) and a PD-1 inhibitor, pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention of a cancer or a tumor, in particular wherein the cancer or tumor is KRAS G12C mutated.

Abstract: Methods and systems to prevent adverse exchange limit effects are disclosed. An example method of message management includes tracking, at a gateway, a transaction count of trade messages communicated to an exchange via an exchange link. The example method includes defining a first transaction limit based on the transaction count, and calculating a second transaction limit as a function of the first transaction limit, wherein the second transaction limit is to correspond to a reserve capacity associated with the exchange link. The example method includes assigning a message priority to each of a plurality of trade messages to communicate to the exchange. The example method includes communicating trade messages of the plurality of trade messages having a first message priority to the exchange when the transaction count is greater than the second transaction limit, and delaying or rejecting trade messages of the plurality of trade messages having a second message priority.

Abstract: The disclosed embodiments provide trading circles. An example method includes defining a group having a plurality of members, wherein one or more of the plurality of members interacts with an exchange that facilitates market transactions; detecting a first interaction of a first group member with the exchange; and communicating, in response to detecting the first interaction, data related to the first interaction to a second group member before the first group member receives confirmation of the first interaction from the exchange.

Abstract: The disclosed embodiments provide trading circles. An example method includes defining a group having a plurality of members, wherein one or more of the plurality of members interacts with an exchange that facilitates market transactions; detecting a first interaction of a first group member with the exchange; and communicating, in response to detecting the first interaction, data related to the first interaction to a second group member before the first group member receives confirmation of the first interaction from the exchange.

Abstract: A method for distributed pod-editing may be performed by an enhanced pod editor, and may include the following steps: receiving a framework for a pod, wherein the framework identifies one or more content items already assigned to one or more slots in the pod by one or more pod editors; determining attributes of the content items already assigned to the pod in a native taxonomy of the enhanced pod editor; determining restrictions on the pod's slots based on the attributes of the content items already assigned to the pod and on the pod's editorial constraints; rejecting content items already assigned to the pod that violate the restrictions on the pod's slots (if any); identifying candidate content items that comply with the restrictions on the pod's unfilled slots (if any), and selecting candidate content items and assigning the selected content items to the pod's unfilled slots.

Abstract: Examples of the systems and methods described herein relate to reducing latency issues associated with playing online digital video on client devices. An example method includes: determining a likelihood that a user will trigger presentment of video content within a portion of digital content, and when the likelihood is determined to exceed a threshold, obtaining a video tag that identifies the video content or caching a portion of the video content prior to presentment of the video content.

Abstract: Examples of the systems and methods described herein relate to reducing latency issues associated with playing online digital video on client devices. An example method includes: determining that a client device of a user is displaying a web page; determining a likelihood that the user will select content on the web page, the content being associated with a digital video; determining that the likelihood exceeds a threshold and, based thereon: identifying the digital video associated with the content; obtaining a copy of a video file including the digital video and an initial portion that precedes the digital video; initiating a video player for displaying the digital video; determining a start location in the video file where the initial portion ends and the digital video begins; and configuring the video player to begin playing the video file from the start location when the user selects the content.

Abstract: Methods and systems to prevent adverse exchange limit effects are disclosed. An example method of message management includes tracking, at a gateway, a transaction count of trade messages communicated to an exchange via an exchange link. The example method includes defining a first transaction limit based on the transaction count, and calculating a second transaction limit as a function of the first transaction limit, wherein the second transaction limit is to correspond to a reserve capacity associated with the exchange link. The example method includes assigning a message priority to each of a plurality of trade messages to communicate to the exchange. The example method includes communicating trade messages of the plurality of trade messages having a first message priority to the exchange when the transaction count is greater than the second transaction limit, and delaying or rejecting trade messages of the plurality of trade messages having a second message priority.

Abstract: Methods and systems to prevent adverse exchange limit effects are disclosed. An example method of message management includes tracking, at a gateway, a transaction count of trade messages communicated to an exchange via an exchange link. The example method includes defining a first transaction limit based on the transaction count, and calculating a second transaction limit as a function of the first transaction limit, wherein the second transaction limit is to correspond to a reserve capacity associated with the exchange link. The example method includes assigning a message priority to each of a plurality of trade messages to communicate to the exchange. The example method includes communicating trade messages of the plurality of trade messages having a first message priority to the exchange when the transaction count is greater than the second transaction limit, and delaying or rejecting trade messages of the plurality of trade messages having a second message priority.

Abstract: The disclosed embodiments provide trading circles. An example method includes defining a group having a plurality of members, wherein one or more of the plurality of members interacts with an exchange that facilitates market transactions; detecting a first interaction of a first group member with the exchange; and communicating, in response to detecting the first interaction, data related to the first interaction to a second group member before the first group member receives confirmation of the first interaction from the exchange.

Abstract: Examples of the systems and methods described herein relate to reducing latency issues associated with playing online digital video on client devices. An example method includes: determining that a client device of a user is displaying a web page; determining a likelihood that the user will select content on the web page associated with a digital video; and determining that the likelihood exceeds a threshold and, based thereon, performing at least one of the following steps before the user selects the content: initiating a mediation process to identify the digital video associated with the content; unwrapping a video tag associated with the digital video; storing at least a portion of the digital video on the client device; stitching the digital video together with a second digital video; and/or initializing a video player for displaying the digital video on the client device.

Abstract: The disclosed embodiments provide trading circles. An example method includes defining a group having a plurality of members, wherein one or more of the plurality of members interacts with an exchange that facilitates market transactions; detecting a first interaction of a first group member with the exchange; and communicating, in response to detecting the first interaction, data related to the first interaction to a second group member before the first group member receives confirmation of the first interaction from the exchange.

Abstract: Examples of the systems and methods described herein relate to reducing latency issues associated with playing online digital video on client devices. An example method includes: determining that a client device of a user is displaying a web page; determining a likelihood that the user will select content on the web page, the content being associated with a digital video; determining that the likelihood exceeds a threshold and, based thereon: identifying the digital video associated with the content; obtaining a copy of a video file including the digital video and an initial portion that precedes the digital video; initiating a video player for displaying the digital video; determining a start location in the video file where the initial portion ends and the digital video begins; and configuring the video player to begin playing the video file from the start location when the user selects the content.

Abstract: Examples of the systems and methods described herein relate to reducing latency issues associated with playing online digital video on client devices. An example method includes: determining that a client device of a user is displaying a web page; determining a likelihood that the user will select content on the web page, the content being associated with a digital video; determining that the likelihood exceeds a threshold and, based thereon: identifying the digital video associated with the content; obtaining a copy of a video file including the digital video and an initial portion that precedes the digital video; initiating a video player for displaying the digital video; determining a start location in the video file where the initial portion ends and the digital video begins; and configuring the video player to begin playing the video file from the start location when the user selects the content.

Abstract: A method for distributed pod-editing may be performed by an enhanced pod editor, and may include the following steps: receiving a framework for a pod, wherein the framework identifies one or more content items already assigned to one or more slots in the pod by one or more pod editors; determining attributes of the content items already assigned to the pod in a native taxonomy of the enhanced pod editor; determining restrictions on the pod's slots based on the attributes of the content items already assigned to the pod and on the pod's editorial constraints; rejecting content items already assigned to the pod that violate the restrictions on the pod's slots (if any); identifying candidate content items that comply with the restrictions on the pod's unfilled slots (if any), and selecting candidate content items and assigning the selected content items to the pod's unfilled slots

Abstract: A method for distributed pod-editing may be performed by an enhanced pod editor, and may include the following steps: receiving a framework for a pod, wherein the framework identifies one or more content items already assigned to one or more slots in the pod by one or more pod editors; determining attributes of the content items already assigned to the pod in a native taxonomy of the enhanced pod editor; determining restrictions on the pod's slots based on the attributes of the content items already assigned to the pod and on the pod's editorial constraints; rejecting content items already assigned to the pod that violate the restrictions on the pod's slots (if any); identifying candidate content items that comply with the restrictions on the pod's unfilled slots (if any), and selecting candidate content items and assigning the selected content items to the pod's unfilled slots.

Abstract: Examples of the systems and methods described herein relate to reducing latency issues associated with playing online digital video on client devices. An example method includes: determining that a client device of a user is displaying a web page; determining a likelihood that the user will select content on the web page associated with a digital video; and determining that the likelihood exceeds a threshold and, based thereon, performing at least one of the following steps before the user selects the content: initiating a mediation process to identify the digital video associated with the content; unwrapping a video tag associated with the digital video; storing at least a portion of the digital video on the client device; stitching the digital video together with a second digital video; and/or initializing a video player for displaying the digital video on the client device.