Abstract: A playback device includes a port configured to receive content from an external memory device, a device memory residing in the device, and a controller programmed to execute instructions that cause the controller to read a read data pattern from the defined region in the external memory device and determine if the read data pattern correlates to an expected data pattern to a predetermined level, wherein the expected data pattern is derived at least in part from a defect map of the defined region.

Abstract: A playback device includes a port configured to receive content from an external memory device, a device memory residing in the device, and a controller programmed to execute instructions that cause the controller to read a read data pattern from the defined region in the external memory device and determine if the read data pattern correlates to an expected data pattern to a predetermined level, wherein the expected data pattern is derived at least in part from a defect map of the defined region.

Abstract: A bottom hole assembly comprising a downhole tool known as a cutting tool is provided for use within a subterranean well for severing tubulars. The cutting tool comprises a fluid source, a gas-driven rotatable motor and a cutting head including one or more cutters. The fluid source supplies pressurized fluid and thereby energy to the gas-driven rotatable motor which is disposed to generate thrust to set the gas-driven rotatable motor in motion. The cutting head is coupled to the gas-driven rotatable motor and rotates while cutting the tubular. The cutting tool can be deployed in a subterranean well by a variety of deployment methods, and the pressurized fluid may be supplied from a surface system, generated inside the cutting tool or bottom hole assembly, or input within the cutting tool or bottom hole assembly prior to deployment. The invention further relates to associated methods.

Abstract: Systems and methods are disclosed that enable efficient well completion operations and provide the ability of flushing the wellbore before, during and after a fracturing or treatment operation, such that a resettable plug and associated bottom hole assembly is not trapped or buried by fluids and particulates in the hole and the sealing element of the resettable plug is not damaged. Systems and methods which mitigate and prevent accumulation of fluids and particulates above a resettable plug are also provided. Systems and methods for delivering pressurized fluid to a subterranean formation are also disclosed.

Abstract: AKR1C3-activated prodrugs of Formula (I), pharmaceutical compositions comprising prodrugs of Formula (I), and their use in the treatment of hyperproliferative diseases such as cancer and for cell ablation. The compounds of the invention are able to penetrate neoplasm tissue and be selectively reduced to an active (cytotoxic) form by contact with an AKR1C3 enzyme found in the neoplasm. This active form is therefore able to ablate AKR1C3-expressing target cells of the neoplasm and therefore has particular utility in the treatment of cancer and other hyperproliferative disorders.

Abstract: A bottom hole assembly comprising a downhole tool known as a cutting tool is provided for use within a subterranean well for severing tubulars. The cutting tool comprises a fluid source, a gas-driven rotatable motor and a cutting head including one or more cutters. The fluid source supplies pressurized fluid and thereby energy to the gas-driven rotatable motor which is disposed to generate thrust to set the gas-driven rotatable motor in motion. The cutting head is coupled to the gas-driven rotatable motor and rotates while cutting the tubular. The cutting tool can be deployed in a subterranean well by a variety of deployment methods, and the pressurized fluid may be supplied from a surface system, generated inside the cutting tool or bottom hole assembly, or input within the cutting tool or bottom hole assembly prior to deployment. The invention further relates to associated methods.

Abstract: A system and method are disclosed which enables the downhole provision of fluid to downhole tools that require fluid for pressurization. The system is prefilled with fluid at surface, is modular in design with a first module delivering fluid to second module and may additionally be mounted below the downhole tools requiring the fluid. Methods are disclosed which utilize the system in a bottom hole assembly during downhole operations for isolating segments of a borehole.

Abstract: A method may include: introducing a fluid comprising a first immiscible phase and a second immiscible phase into a contacting vessel comprising multiple contact stages: flowing the fluid through a first fiber bundle disposed in the contacting vessel; separating at least a portion of the first immiscible phase from the second immiscible phase; and flowing the separated portion of the first immiscible phase through a second fiber bundle disposed in the contacting vessel.

Abstract: Embodiments of the present invention disclose a standoff assembly for a sucker rod used for sucker rod pumps. The assembly includes an annulus body, a hole that passes through the annulus body, the hole configured to permit a sucker rod to translate through the hole, a sliding material component located along the surface of the hole, and a temporary component; wherein upon elimination of the temporary component, the sliding material component interacts with the sucker rod to reduce sliding friction as the sucker rod translates through the assembly.

Abstract: Systems and methods are disclosed that enable efficient well completion operations and provide the ability of flushing the wellbore before, during and after a fracturing or treatment operation, such that a resettable plug and associated bottom hole assembly is not trapped or buried by fluids and particulates in the hole and the sealing element of the resettable plug is not damaged. Systems and methods which mitigate and prevent accumulation of fluids and particulates above a resettable plug are also provided. Systems and methods for delivering pressurized fluid to a subterranean formation are also disclosed.

Abstract: Fibroblast Growth Factor Receptor kinase inhibitors and prodrugs thereof of Formula (I) and their use for the treatment of hyper-proliferative diseases such as retinopathy, psoriasis, rheumatoid arthritis, osteoarthritis, septic arthritis, tumour metastasis, periodontal disease, corral ulceration, proteinuria, coronary thrombosis from atherosclerotic plaque, aneurismal aorta, dystrophobic epidermolysis bullosa, degenerative cartilage loss following traumatic joint injury, osteopenias mediated by MMP activity, tempero mandibular joint disease, and demyelating disease of the nervous system.

Abstract: Embodiments of the present invention disclose a standoff assembly for a sucker rod used for sucker rod pumps. The assembly includes an annulus body, a hole that passes through the annulus body, the hole configured to permit a sucker rod to translate through the hole, a sliding material component located along the surface of the hole, and a temporary component; wherein upon elimination of the temporary component, the sliding material component interacts with the sucker rod to reduce sliding friction as the sucker rod translates through the assembly.

Abstract: Systems and methods are disclosed that enable flushing the wellbore before, during and after a fracturing or treatment operation, such that a resettable plug is not trapped or buried by fluids and particulates in the hole and the sealing element of the resettable plug is not damaged. Systems and methods which mitigate and prevent accumulation of fluids and particulates above a resettable plug are also provided. A system and method for delivering pressurized fluid to a subterranean formation is also disclosed.

Abstract: A stemming plug (60) for stemming a blast hole in a mine is disclosed. The plug has first and second wedge-shaped members (62?, 62) manufactured from a suitable plastics material. The first wedge-shaped member (62?) has a first sloping face received in sliding relationship with a matching face of the second wedge-shaped member (62) wherein, in use, when the first wedge-shaped member (62?) is positioned nearest to an explosive material in the blast hole it has a larger surface area facing the explosive material than the second wedge-shaped member (62). In use, when a Shockwave from initiation of the explosive material in the blast hole encounters the first wedge-shaped member (62?) it acts as a piston, sliding on the second wedge-shaped member (62) so that both wedge-shaped members exert diametrically opposed forces against the wall of the blast hole to lock the plug (60) in place. The two wedge-shaped members (62?, 62) may be substantially identical, thus significantly simplifying the manufacturing process.

Abstract: A method may include: introducing a fluid comprising a first immiscible phase and a second immiscible phase into a contacting vessel comprising multiple contact stages: flowing the fluid through a first fiber bundle disposed in the contacting vessel; separating at least a portion of the first immiscible phase from the second immiscible phase; and flowing the separated portion of the first immiscible phase through a second fiber bundle disposed in the contacting vessel.

Abstract: A process is presented to treat a process stream containing a hydrocarbon (oil and/or gas) and hydrogen sulfide with a liquid treatment solution containing a sulfur dye catalyst. The process stream can be within a pipeline, wellbore, subsea pipeline or a wellhead that contains hydrogen sulfide where the liquid treatment solution is injected at a predetermined point to define a scavenger zone such that the sulfur dye catalyst in the liquid treatment solution causes the sulfide from the hydrogen sulfide to react with the catalyst. The hydrocarbon component is separated substantially free of the hydrogen sulfide from a spent treatment solution containing spent sulfur dye catalyst which can then be fed to an oxidation vessel where it is contacted with an oxygen containing gas causing the sulfide to oxidize to thiosulfate and converting the spent sulfur dye catalyst to regenerated sulfur dye catalyst.

Abstract: The present invention relates to selective presenilin-2 ?-secretase inhibitors for use in the treatment of various diseases associated with a defect leading to Notch receptor hyperactivity. In particular the present invention relates to selective presenilin-2 ?-secretase inhibitors for use as a highly selective anti-cancer treatment. Preferred selective presenilin-2 ?-secretase inhibitors include small molecules, like 4-aminoquinolines or imidazole compounds, (monoclonal) antibodies and known ?-secretase inhibitors or analogues and combinations thereof.

Abstract: AKR1C3-activated prodrugs of Formula (I), pharmaceutical compositions comprising prodrugs of Formula (I), and their use in the treatment of hyperproliferative diseases such as cancer and for cell ablation. The compounds of the invention are able to penetrate neoplasm tissue and be selectively reduced to an active (cytotoxic) form by contact with an AKR1C3 enzyme found in the neoplasm. This active form is therefore able to ablate AKR1C3-expressing target cells of the neoplasm and therefore has particular utility in the treatment of cancer and other hyperproliferative disorders.

Abstract: A process is presented where a feed stream containing a hydrogen sulfide and another feed component is introduced into an absorber that the feed stream flows upward from the bottom of the absorber and contacts a liquid treatment solution, where the liquid treatment solution contains a sulfur dye catalyst. The hydrogen sulfide is absorbed into the liquid treatment solution and converted into sulfide ions. The other feed component is removed from the absorber vessel substantially free of the hydrogen sulfide and a spent treatment solution is also removed from the absorber vessel and fed to an oxidation vessel where it is contacted with an oxygen containing gas causing the sulfide ions to oxidize to thiosulfate and converting the spent sulfur dye catalyst to regenerated sulfur dye catalyst. The thiosulfate is recovered, and the regenerated sulfur dye catalyst can be recycled as part of the liquid treatment solution.