Patents by Inventor Jeffrey Colbeck

Jeffrey Colbeck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LANTIBIOTIC VARIANTS AND USES THEREOF
    Publication number: 20190315814
    Abstract: The disclosure relates to lantibiotic structural variants that have improved antimicrobial properties when compared to wild-type lantibiotics, and uses thereof. Embodiments include non-naturally occurring lantibiotics.
    Type: Application
    Filed: July 14, 2017
    Publication date: October 17, 2019
    Inventors: Martin HANDFIELD, Johan Anthony KERS, Sheela MULEY, Melissa MAYO, Jeffrey COLBECK, Robert Eryl SHARP, Albert G. FOSMOE, II, Anthony W. DEFUSCO
  • COMBINED AUTOMATED PARALLEL SYNTHESIS OF POLYNUCLEOTIDE VARIANTS
    Publication number: 20150024971
    Abstract: The present disclosure relates to methods for efficient synthesis, cloning, transformation and screening of large diverse libraries of polynucleotide variants comprising well-defined nucleotide differences relative to a reference polynucleotide.
    Type: Application
    Filed: October 2, 2014
    Publication date: January 22, 2015
    Inventors: Jeffrey Colbeck, Benjamin N. Mijts, Lorraine J. Giver, Richard Fox, Vesna Mitchell, Bumshik Robert Pak, Lynne D. Gilson
  • Biocatalytic processes for the preparation of stereomerically pure fused bicyclic proline compounds
    Patent number: 8574876
    Abstract: The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: November 5, 2013
    Assignee: Codexis, Inc.
    Inventors: Benjamin Mijts, Sheela Muley, Jack Liang, Lisa M. Newman, Xiyun Zhang, James Lalonde, Michael D. Clay, Jun Zhu, John M. Gruber, Jeffrey Colbeck, John D. Munger, Jr., Jagadeesh Mavinahalli, Roger Sheldon
  • Combined automated parallel synthesis of polynucleotide variants
    Patent number: 8383346
    Abstract: The present disclosure relates to methods for efficient synthesis, cloning, transformation and screening of large diverse libraries of polynucleotide variants comprising well-defined nucleotide differences relative to a reference polynucleotide.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: February 26, 2013
    Assignee: Codexis, Inc.
    Inventors: Jeffrey Colbeck, Benjamin Mijts, Lorraine Joan Giver, Richard J. Fox, Vesna Mitchell, Bumshik Robert Pak, Lynne Gilson
  • Biocatalytic Processes for the Preparation of Stereomerically Pure Fused Bicyclic Proline Compounds
    Publication number: 20120244581
    Abstract: The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
    Type: Application
    Filed: March 30, 2012
    Publication date: September 27, 2012
    Applicant: CODEXIS, INC.
    Inventors: Benjamin Mijts, Sheela Muley, Jack Liang, Lisa M. Newman, Xiyun Zhang, James Lalonde, Michael D. Clay, Jun Zhu, John M. Gruber, Jeffrey Colbeck, John D. Munger, JR., Jagadeesh Mavinahalli, Roger Sheldon
  • Stereomerically Pure Fused Bicyclic Proline Compounds Useful for Preparing Hepatitis C Protease Inhibitors
    Publication number: 20120130087
    Abstract: The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
    Type: Application
    Filed: November 11, 2011
    Publication date: May 24, 2012
    Applicant: CODEXIS, INC.
    Inventors: Benjamin Mijts, Sheela Muley, Jack Liang, Lisa M. Newman, Xiyun Zhang, James Lalonde, Michael D. Clay, Jun Zhu, John M. Gruber, Jeffrey Colbeck, John D. Munger, JR., Jagadeesh Mavinahalli, Roger Sheldon
  • Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds
    Patent number: 8178333
    Abstract: The present disclosure provides monoamine oxidase enzymes and methods of their use in biocatalytic processes for the preparation of substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: May 15, 2012
    Assignee: Codexis, Inc.
    Inventors: Benjamin Mijts, Sheela Muley, Jack Liang, Lisa M. Newman, Xiyun Zhang, James Lalonde, Michael D. Clay, Jun Zhu, John M. Gruber, Jeffrey Colbeck, John D. Munger, Jr., Jagadeesh Mavinahalli, Roger Sheldon
  • COMBINED AUTOMATED PARALLEL SYNTHESIS OF POLYNUCLEOTIDE VARIANTS
    Publication number: 20100093560
    Abstract: The present disclosure relates to methods for efficient synthesis, cloning, transformation and screening of large diverse libraries of polynucleotide variants comprising well-defined nucleotide differences relative to a reference polynucleotide.
    Type: Application
    Filed: September 18, 2009
    Publication date: April 15, 2010
    Applicant: CODEXIS, INC.
    Inventors: Jeffrey Colbeck, Benjamin Mijts, Lorraine Joan Giver, Richard Fox
  • BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS
    Publication number: 20100063300
    Abstract: The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
    Type: Application
    Filed: June 23, 2009
    Publication date: March 11, 2010
    Applicant: Codexis, Inc.
    Inventors: Benjamin Mijts, Sheela Muley, Jack Liang, Lisa M. Newman, Xiyun Zhang, James Lalonde, Michael D. Clay, Jun Zhu, John M. Gruber, Jeffrey Colbeck, John D. Munger, JR., Jagadeesh Mavinahalli, Roger Sheldon
  • METHOD OF SYNTHESIZING POLYNUCLEOTIDE VARIANTS
    Publication number: 20090312196
    Abstract: The present disclosure relates to methods for generating libraries of polynucleotide variants comprising defined nucleotide differences relative to a reference polynucleotide.
    Type: Application
    Filed: June 11, 2009
    Publication date: December 17, 2009
    Applicant: CODEXIS, INC.
    Inventors: Jeffrey Colbeck, Benjamin Mijts, Lorraine Joan Giver, Richard J. Fox