Patents by Inventor Jeffrey Douglas Wilson

Jeffrey Douglas Wilson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Co-crystals of neflamapimod (VX-745)
    Patent number: 11466008
    Abstract: Provided herein are co-crystal forms comprising 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one (VX-745): and compositions thereof, useful as inhibitors of one or more protein kinases and which exhibit desirable characteristics for the same.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: October 11, 2022
    Assignee: EIP Pharma, LLC
    Inventors: John Jahangir Alam, Jeffrey Douglas Wilson
  • Pharmaceutical formulations of neflamapimod
    Patent number: 10653695
    Abstract: Disclosed are oral pharmaceutical compositions of neflamapimod that exhibit suitable exposure for administration in humans and/or that maintain a desirable dissolution profile under standard storage conditions.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: May 19, 2020
    Assignee: EIP Pharma, LLC
    Inventors: John Jahangir Alam, Jeffrey Douglas Wilson
  • PHARMACEUTICAL FORMULATIONS OF NEFLAMAPIMOD
    Publication number: 20190275045
    Abstract: Disclosed are oral pharmaceutical compositions of neflamapimod that exhibit suitable exposure for administration in humans and/or that maintain a desirable dissolution profile under standard storage conditions.
    Type: Application
    Filed: March 12, 2019
    Publication date: September 12, 2019
    Inventors: John Jahangir Alam, Jeffrey Douglas Wilson
  • Process for synthesizing bicyclic compounds from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor
    Publication number: 20040138453
    Abstract: The invention relates to a process for simultaneously N(2)-acylating piperazic acid or an ester thereof and forming a bicyclic ring structure. The invention also relates to the use of that process step in a method of synthesizing a bicyclic compound useful as an intermediate for the production of an inhibitor of a caspase, particularly an inhibitor of interleukin-1&bgr; converting enzyme (“ICE”).
    Type: Application
    Filed: May 5, 2003
    Publication date: July 15, 2004
    Inventors: Andrea L. C. Robidoux, Jeffrey Douglas Wilson, Petra Dieterich, Neil Storer, Stefania Leonardi
  • Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors
    Patent number: 6703500
    Abstract: The invention relates to a process for synthesizing piperazic acid and similar, ring-containing acids. The invention also relates to a process for simultaneously N(2)-acylating piperazic acid or an ester thereof and forming a bicyclic ring structure. The invention also relates to the use of either or both processes in a method of synthesizing a bicyclic compound useful as an intermediate for the production of an inhibitor of a caspase, particularly an inhibitor of interleukin-1&bgr; converting enzyme (“ICE”).
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: March 9, 2004
    Assignee: Vertex Pharmaceuticals, Incorporated
    Inventors: Andrea L. C. Robidoux, Jeffrey Douglas Wilson, Petra Dieterich, Neil Storer, Stefania Leonardi
  • Method for synthesizing caspase inhibitors
    Patent number: 6559304
    Abstract: The invention relates to a process for simultaneously N(2)-acylating piperazic acid or an ester thereof and forming a bicyclic ring structure. The invention also relates to the use of that process step in a method of synthesizing a bicyclic compound useful as an intermediate for the production of an inhibitor of a caspase, particularly an inhibitor of interleukin-1&bgr; converting enzyme (“ICE”).
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: May 6, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Andrea L. C. Robidoux, Jeffrey Douglas Wilson, Petra Dieterich, Neil Storer, Stefania Leonardi
  • Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors
    Publication number: 20010031862
    Abstract: The invention relates to a process for synthesizing piperazic acid and similar, ring-containing acids. The invention also relates to a process for simultaneously N(2)-acylating piperazic acid or an ester thereof and forming a bicyclic ring structure. The invention also relates to the use of either or both processes in a method of synthesizing a bicyclic compound useful as an intermediate for the production of an inhibitor of a caspase, particularly an inhibitor of interleukin-1&bgr; converting enzyme (“ICE”).
    Type: Application
    Filed: February 20, 2001
    Publication date: October 18, 2001
    Inventors: Andrea L.C. Robidoux, Jeffrey Douglas Wilson, Petra Dieterich, Neil Storer, Stefania Leonardi
  • Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor
    Patent number: 6201118
    Abstract: The invention relates to a process for simultaneously N(2)-acylating piperazic acid or an ester thereof and forming a bicyclic ring structure. The invention also relates to the use of that process step in a method of synthesizing a bicyclic compound useful as an intermediate for the production of an inhibitor of a caspase, particularly an inhibitor of interleukin-1&bgr; converting enzyme (“ICE”).
    Type: Grant
    Filed: August 19, 1998
    Date of Patent: March 13, 2001
    Assignee: Vertex Pharmaceuticals Inc.
    Inventors: Andrea L. C. Robidoux, Jeffrey Douglas Wilson, Petra Dietrich, Neil Storer, Stefania Leonardi