Abstract: It relates to a pharmaceutical combination comprising a KRAS G12C inhibitor, in particular 1-{6-[(4M)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro [3.3] heptan-2-yl} prop-2-en-1-one (Compound A) and one or more therapeutically active agents selected from a SHP2 inhibitor (e.g. TNO155) and a PD-1 inhibitor, pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention of a cancer or a tumor, in particular wherein the cancer or tumor is KRAS G12C mutated.

Abstract: Systems and method presented herein enable the estimation of porosity using neutron-induced gamma ray spectroscopy. For example, the systems and methods presented herein include receiving, via a control and data acquisition system, data relating to energy spectra of gamma rays captured by one or more gamma ray detectors of a neutron-induced gamma ray spectroscopy logging tool. The method also includes deriving, via the control and data acquisition system, one or more spectral yields relating to one or more elemental components from the data relating to the energy spectra of the gamma rays. The method further includes estimating, via the control and data acquisition system, a measurement of porosity based on the one or more spectral yields relating to the one or more elemental components.

Abstract: An air-conditioning service plug-type valve includes a valve body having a chamber. First and second openings extend through the valve body. The air conditioning plug-type valve also includes a stem having a plug portion configured for being received in the chamber of the valve body. The stem, when the plug portion is received in the chamber, is rotatable relative to the valve body between a closed position blocking fluid communication between the first and second openings of the valve body and an open position enabling fluid communication between the first and second openings of the valve body. The plug portion includes a fluid blocking portion located immediately adjacent the first opening when the stem is in the closed position. A groove extends into a peripheral surface of the plug portion defining the fluid blocking portion. A seal is disposed in the groove and extends between the plug portion and the valve body. The seal, when located in the groove, is stretched by at least a predetermined amount.

Abstract: A closure cap comprises a base having at an inner side thereof an annular gland for receiving an annular seal. The annular gland has a bottom surface and an annular side surface depending from the bottom surface. A skirt depends from base and has an internal fastening thread for attaching the cap to a correspondingly but externally threaded body. Additionally, the annular side surface of the annular gland has a venting thread depending from the bottom surface of the gland to enable venting of air that may otherwise be trapped behind the annular seal when fitted in the gland. Also disclosed is a method of molding the cap.

Abstract: A distributor, for use in a refrigerant system for conveying refrigerant between an expansion device and an evaporator, having a longitudinal body, an actuator, a plug, a first nozzle, and a second nozzle. The longitudinal body having a first end, a second end, a longitudinal passage between the first and second ends. The first nozzle being affixed within the passage. The second nozzle being rotatable within the passage for alignment and misalignment with the first nozzle. The second nozzle having a plurality of gear teeth engageable with the actuator, which is adjustable. A method of mixing refrigerant fluid while passing through the distributor.