Patents by Inventor Jeffrey H. Lawson
Jeffrey H. Lawson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11938260Abstract: An apparatus for guiding cannulation with a dialysis needle of an arteriovenous dialysis access graft subcutaneously implanted in a body of a subject. The guiding apparatus comprises an elongated body member comprising a base portion terminating in longitudinal edges, a distance between the longitudinal edges of the base portion being substantially equal to a lateral dimension of the aces graft, and an elongated tubular sleeve defining an pocket having a longitudinal dimension and a lateral dimension configured to receive the body member. The body member is adapted to be received in the pocket of the sleeve for securing adjacent the subcutaneous access graft such that the inner surface of the base portion is aligned with a cannulation point of the graft for guiding location of a needle insertion.Type: GrantFiled: July 19, 2021Date of Patent: March 26, 2024Assignee: InnAVasc Medical, Inc.Inventors: Shawn M. Gage, Jeffrey H. Lawson, Joseph Knight, Craig Nichols
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Publication number: 20230043946Abstract: An arteriovenous dialysis access graft configured to be implanted in a subject includes: at least one flexible conduit having first and second end portions, wherein the first end portion is configured to connect to an artery of the subject and the second end portion is configured to connect to a vein of the subject such that blood flows through the at least one conduit from the first end portion to the second end portion; and at least one cannulation chamber positioned between the first end portion and the second end portion of the at least one conduit. The chamber includes: an elongated housing having an inlet at a first end thereof and an outlet at a second, opposed end thereof, a posterior wall, a pair of sidewalls, and an open anterior portion defining a cannulation port; a self-sealing material extending across the cannulation port; and a longitudinal passageway defined by the housing and the self-sealing material that extends from the inlet to the outlet of the housing.Type: ApplicationFiled: October 20, 2022Publication date: February 9, 2023Inventors: Shawn M. Gage, Jeffrey H. Lawson
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Patent number: 11504461Abstract: An arteriovenous dialysis access graft configured to be implanted in a subject includes: at least one flexible conduit having first and second end portions, wherein the first end portion is configured to connect to an artery of the subject and the second end portion is configured to connect to a vein of the subject such that blood flows through the at least one conduit; and at least one cannulation chamber positioned between the first end portion and the second end portion of the at least one conduit. The chamber includes: an elongated housing having an inlet and an outlet, a posterior wall, a pair of sidewalls, and an open anterior portion defining a cannulation port; and a self-sealing material extending across the cannulation port. The posterior wall and the sidewalls of the housing are formed of a substantially rigid material.Type: GrantFiled: September 24, 2019Date of Patent: November 22, 2022Assignee: W. L. Gore & Associates, Inc.Inventors: Shawn M. Gage, Jeffrey H. Lawson
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Publication number: 20210346585Abstract: An apparatus for guiding cannulation with a dialysis needle of an arteriovenous dialysis access graft subcutaneously implanted in a body of a subject. The guiding apparatus comprises an elongated body member comprising a base portion terminating in longitudinal edges, a distance between the longitudinal edges of the base portion being substantially equal to a lateral dimension of the aces graft, and an elongated tubular sleeve defining an pocket having a longitudinal dimension and a lateral dimension configured to receive the body member. The body member is adapted to be received in the pocket of the sleeve for securing adjacent the subcutaneous access graft such that the inner surface of the base portion is aligned with a cannulation point of the graft for guiding location of a needle insertion.Type: ApplicationFiled: July 19, 2021Publication date: November 11, 2021Inventors: Shawn M. Gage, Jeffrey H. Lawson, Joseph Knight, Craig Nichols
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Patent number: 11065377Abstract: An apparatus for guiding cannulation with a dialysis needle of an arteriovenous dialysis access graft subcutaneously implanted in a body of a subject. The guiding apparatus comprises an elongated body member comprising a base portion terminating in longitudinal edges, a distance between the longitudinal edges of the base portion being substantially equal to a lateral dimension of the aces graft, and an elongated tubular sleeve defining an pocket having a longitudinal dimension and a lateral dimension configured to receive the body member. The body member is adapted to be received in the pocket of the sleeve for securing adjacent the subcutaneous access graft such that the inner surface of the base portion is aligned with a cannulation point of the graft for guiding location of a needle insertion.Type: GrantFiled: March 30, 2018Date of Patent: July 20, 2021Assignee: InnAVasc Medical, Inc.Inventors: Shawn M. Gage, Jeffrey H. Lawson, Joseph Knight, Craig Nichols
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Publication number: 20200016320Abstract: An arteriovenous dialysis access graft configured to be implanted in a subject includes: at least one flexible conduit having first and second end portions, wherein the first end portion is configured to connect to an artery of the subject and the second end portion is configured to connect to a vein of the subject such that blood flows through the at least one conduit; and at least one cannulation chamber positioned between the first end portion and the second end portion of the at least one conduit. The chamber includes: an elongated housing having an inlet and an outlet, a posterior wall, a pair of sidewalls, and an open anterior portion defining a cannulation port; and a self-sealing material extending across the cannulation port. The posterior wall and the sidewalls of the housing are formed of a substantially rigid material.Type: ApplicationFiled: September 24, 2019Publication date: January 16, 2020Inventors: Shawn M. Gage, Jeffrey H. Lawson
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Patent number: 10420874Abstract: An arteriovenous dialysis access graft configured to be implanted in a subject includes: at least one flexible conduit having first and second end portions, wherein the first end portion is configured to connect to an artery of the subject and the second end portion is configured to connect to a vein of the subject such that blood flows through the at least one conduit; and at least one cannulation chamber positioned between the first end portion and the second end portion of the at least one conduit. The chamber includes: an elongated housing having an inlet and an outlet, a posterior wall, a pair of sidewalls, and an open anterior portion defining a cannulation port; and a self-sealing material extending across the cannulation port. The posterior wall and the sidewalls of the housing are formed of a substantially rigid material.Type: GrantFiled: March 6, 2017Date of Patent: September 24, 2019Assignee: Duke UniversityInventors: Shawn M. Gage, Jeffrey H. Lawson
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Publication number: 20180289883Abstract: An apparatus for guiding cannulation with a dialysis needle of an arteriovenous dialysis access graft subcutaneously implanted in a body of a subject. The guiding apparatus comprises an elongated body member comprising a base portion terminating in longitudinal edges, a distance between the longitudinal edges of the base portion being substantially equal to a lateral dimension of the aces graft, and an elongated tubular sleeve defining an pocket having a longitudinal dimension and a lateral dimension configured to receive the body member. The body member is adapted to be received in the pocket of the sleeve for securing adjacent the subcutaneous access graft such that the inner surface of the base portion is aligned with a cannulation point of the graft for guiding location of a needle insertion.Type: ApplicationFiled: March 30, 2018Publication date: October 11, 2018Inventors: Shawn M. Gage, Jeffrey H. Lawson, Joseph Knight, Craig Nichols
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Publication number: 20180280605Abstract: An arteriovenous dialysis access graft is configured to be implanted in a body of a subject. The arteriovenous dialysis graft comprises a flexible conduit defining a longitudinal flow passageway. The conduit has a first end portion and a second end portion, the first end portion configured to connect to an artery of the subject and the second end portion configured to connect to a vein of the subject such that blood flows through the longitudinal flow passageway of the conduit from the first end portion to the second end portion. The graft further comprises a first cannulation chamber and a spaced second cannulation chamber with the conduit extending through each of the first chamber and the second chamber. The first chamber is positioned between the first end portion and the second chamber, and the second chamber is positioned between the second end portion and the first chamber. A valve device is positioned between the first cannulation chamber and the second cannulation chamber for controlling fluid flow.Type: ApplicationFiled: March 30, 2018Publication date: October 4, 2018Inventors: Shawn M. Gage, Jeffrey H. Lawson, Joseph Knight, Craig Nichols
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Publication number: 20170173252Abstract: An arteriovenous dialysis access graft configured to be implanted in a subject includes: at least one flexible conduit having first and second end portions, wherein the first end portion is configured to connect to an artery of the subject and the second end portion is configured to connect to a vein of the subject such that blood flows through the at least one conduit; and at least one cannulation chamber positioned between the first end portion and the second end portion of the at least one conduit. The chamber includes: an elongated housing having an inlet and an outlet, a posterior wall, a pair of sidewalls, and an open anterior portion defining a cannulation port; and a self-sealing material extending across the cannulation port. The posterior wall and the sidewalls of the housing are formed of a substantially rigid material.Type: ApplicationFiled: March 6, 2017Publication date: June 22, 2017Inventors: Shawn M. Gage, Jeffrey H. Lawson
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Patent number: 9585998Abstract: An arteriovenous dialysis access graft configured to be implanted in a subject includes: at least one flexible conduit having first and second end portions, wherein the first end portion is configured to connect to an artery of the subject and the second end portion is configured to connect to a vein of the subject such that blood flows through the at least one conduit; and at least one cannulation chamber positioned between the first end portion and the second end portion of the at least one conduit. The chamber includes: an elongated housing having an inlet and an outlet, a posterior wall, a pair of sidewalls, and an open anterior portion defining a cannulation port; and a self-sealing material extending across the cannulation port. The posterior wall and the sidewalls of the housing are formed of a substantially rigid material.Type: GrantFiled: September 16, 2013Date of Patent: March 7, 2017Assignee: Duke UniversityInventors: Shawn M. Gage, Jeffrey H. Lawson
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Publication number: 20140018721Abstract: An arteriovenous dialysis access graft configured to be implanted in a subject includes: at least one flexible conduit having first and second end portions, wherein the first end portion is configured to connect to an artery of the subject and the second end portion is configured to connect to a vein of the subject such that blood flows through the at least one conduit; and at least one cannulation chamber positioned between the first end portion and the second end portion of the at least one conduit. The chamber includes: an elongated housing having an inlet and an outlet, a posterior wall, a pair of sidewalls, and an open anterior portion defining a cannulation port; and a self-sealing material extending across the cannulation port. The posterior wall and the sidewalls of the housing are formed of a substantially rigid material.Type: ApplicationFiled: September 16, 2013Publication date: January 16, 2014Applicant: Duke UniversityInventors: Shawn M. Gage, Jeffrey H. Lawson
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Publication number: 20030125254Abstract: The present invention relates, in general, to vascular smooth muscle proliferation and, in particular, to a method of inhibiting arterial and venous smooth muscle proliferation resulting, for example, from arterial injury, vein grafting or shunt implantation. The invention also relates to an expression construct encoding a G&bgr;&ggr; inhibitor suitable for use in such a method.Type: ApplicationFiled: October 2, 2002Publication date: July 3, 2003Applicant: DUKE UNIVERSITYInventors: Walter J. Koch, Jeffrey H. Lawson
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Patent number: 5399487Abstract: The present invention encompasses compounds of formula I: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof; wherein R.sub.1 is hydrogen, lower alkyl, alkenyl, alkynyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, or phenylalkyl;R.sub.2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, or phenylalkyl; orNR.sub.1 R.sub.2 forms a nitrogen heterocycle; andR.sub.3 is hydrogen, an amino acid or a peptide residue.These compounds may be employed as substrates in assays for determining proteolytic enzyme activity or as enzyme inhibitors. The invention also encompasses methods for determining proteolytic enzyme activity using the compounds of formula I.Type: GrantFiled: March 4, 1993Date of Patent: March 21, 1995Assignee: Haematologic Technologies, Inc.Inventors: Saulius Butenas, Jeffrey H. Lawson, Kenneth G. Mann