Abstract: This disclosure describes systems, methods, and apparatus for detecting and displaying a number of rounds in a firearm magazine comprising a maximum number of N rounds. The magazine may comprise a follower, magnets on the follower, and <N magnetic switches arranged along a path of the magnets when the follower moves along a length of the magazine, the switches configured to activate based on a magnetic field exceeding a threshold, and a first antenna arranged on an inside of the magazine and parallel to a firing direction of the firearm, and configured to wirelessly transmit a round count indication to a second antenna on the firearm, the round count indication based on the round count data, the second antenna affixed to an inside of a magazine well of the firearm and mostly overlapping with the first antenna.

Abstract: An inhibitory nucleic molecule that targets cyclin D1 mRNA is described. Generally, the inhibitory nucleic acid molecule includes a nucleotide sequence that is complementary to at least a portion of SEQ ID NO:1. In one or more embodiments, the inhibitory nucleic acid molecule is complementary to nucleotides 330-350 of SEQ ID NO:1, nucleotides 372-392 of SEQ ID NO:1, nucleotides 525-545 of SEQ ID NO:1, nucleotides 801-825 of SEQ ID NO:1, nucleotides 1206-1230 of SEQ ID NO:1 or nucleotides 2416-2440 of SEQ ID NO:1. The inhibitory nucleic acid molecule can include RNA, DNA, or both. In another aspect, a method of treating a disease of the liver in a subject having, or at risk of having, a disease of the liver generally includes administering to the subject a composition that includes an amount of an inhibitor of cyclin D1 effective to ameliorate at least one symptom or clinical sign of the disease of the liver.

Abstract: This disclosure describes systems, methods, and apparatus for detecting and displaying a number of rounds in a firearm magazine comprising a maximum number of N rounds. The magazine may comprise a follower, magnets on the follower, and <N magnetic-field-sensing sensors arranged along a path of the magnets when the follower moves along a length of the magazine, the sensors generating round count data based on a position of the one or more magnets relative to the <N magnetic-field-sensing sensors, and a first substantially flat antenna arranged on an inside of the magazine and configured to wirelessly transmit a round count indication to a second substantially flat antenna on the firearm, the round count indication based on the round count data, the second substantially flat antenna affixed to an inside of a magazine well of the firearm and mostly overlapping with the first substantially flat antenna.

Abstract: Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells, and methods of treating sensory transduction disorders associated with a genetic defect. Some embodiments are directed to a synthetic inner ear hair cell targeting adeno-associated virus (AAV) vector, a cell comprising the synthetic inner ear hair cell targeting AAV vector, and method of treating Usher Syndrome in a subject using the synthetic inner ear hair cell targeting AAV vector.

Abstract: Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells, and methods of treating sensory transduction disorders associated with a genetic defect. Some embodiments are directed to a synthetic inner ear hair cell targeting adeno-associated virus (AAV) vector, a cell comprising the synthetic inner ear hair cell targeting AAV vector, and method of treating Usher Syndrome in a subject using the synthetic inner ear hair cell targeting AAV vector.

Abstract: According to an aspect of an embodiment, operations may include receiving a first Ethernet signal having a first data rate less than a second data rate, the second data rate being a ZR data rate. The operations may also include dividing the first Ethernet signal into a plurality of first-signal sub-signals that each have a third data rate that is less than the first data rate. Moreover, the operations may include generating a second Ethernet signal having the second data rate, the generating of the second Ethernet signal being based on the plurality of first-signal sub-signals such that the second Ethernet signal includes the plurality of first-signal sub-signals. Further, the operations may include providing the second Ethernet signal to a ZR network such that the second Ethernet signal is a ZR signal.

Abstract: This disclosure describes systems, methods, and apparatus for detecting and displaying a number of rounds in a firearm magazine comprising a maximum number of N rounds. The magazine may comprise a follower, magnets on the follower, and <N magnetic-field-sensing sensors arranged along a path of the magnets when the follower moves along a length of the magazine, the sensors generating round count data based on a position of the one or more magnets relative to the <N magnetic-field-sensing sensors, and a first substantially flat antenna arranged on an inside of the magazine and configured to wirelessly transmit a round count indication to a second substantially flat antenna on the firearm, the round count indication based on the round count data, the second substantially flat antenna affixed to an inside of a magazine well of the firearm and mostly overlapping with the first substantially flat antenna.

Abstract: Telemedicine systems and methods are described. In a telemedicine system operable to communicate with a remote operations center, communications can be transmitted/received using a transceiver having an antenna. The antenna can include first and second di-pole antenna elements, the first di-pole antenna element being vertically polarized and the second di-pole antenna element being horizontally polarized. A controller of the system can establish, using the transceiver, a telemedicine session with the operations center using a Transport Morphing Protocol (TMP), the TMP being an acknowledgement-based user datagram protocol. The controller can also mask one or more transient network degradations to increase resiliency of the telemedicine session.

Abstract: Telemedicine systems and methods are described. In a telemedicine system operable to communicate with a remote operations center, communications can be transmitted/received using a transceiver having an antenna. The antenna can include first and second di-pole antenna elements, the first di-pole antenna element being vertically polarized and the second di-pole antenna element being horizontally polarized. A controller of the system can establish, using the transceiver, a telemedicine session with the operations center using a Transport Morphing Protocol (TMP), the TMP being an acknowledgement-based user datagram protocol. The controller can also mask one or more transient network degradations to increase resiliency of the telemedicine session.

Abstract: According to an aspect of an embodiment, operations may include receiving a first Ethernet signal having a first data rate less than a second data rate, the second data rate being a ZR data rate. The operations may also include dividing the first Ethernet signal into a plurality of first-signal sub-signals that each have a third data rate that is less than the first data rate. Moreover, the operations may include generating a second Ethernet signal having the second data rate, the generating of the second Ethernet signal being based on the plurality of first-signal sub-signals such that the second Ethernet signal includes the plurality of first-signal sub-signals. Further, the operations may include providing the second Ethernet signal to a ZR network such that the second Ethernet signal is a ZR signal.

Abstract: Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells.

Abstract: A method of characterizing an imaging system includes generating a plurality of point spread function (“PSF”) samples using the imaging system, each PSF sample representing a response of an imaging system to a point illumination source, each PSF sample comprising one or more pixel values. The method also includes co-registering the pixel values contained in each of the plurality of PSF samples to form an oversampled point spread function (“PSF”) population; resampling the oversampled PSF population to uniform spacing to form a PSF image; slicing the PSF image in an evaluation direction to form a slice of the PSF image; and evaluating the slice to determine a value of a resolution metric of the imaging system that is specific to the evaluation direction.

Abstract: Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells.

Abstract: A method of characterizing an imaging system includes generating a plurality of point spread function (“PSF”) samples using the imaging system, each PSF sample representing a response of an imaging system to a point illumination source, each PSF sample comprising one or more pixel values. The method also includes co-registering the pixel values contained in each of the plurality of PSF samples to form an oversampled point spread function (“PSF”) population; resampling the oversampled PSF population to uniform spacing to form a PSF image; slicing the PSF image in an evaluation direction to form a slice of the PSF image; and evaluating the slice to determine a value of a resolution metric of the imaging system that is specific to the evaluation direction.

Abstract: This disclosure describes systems, methods, and apparatus for detecting and displaying a number of rounds in a firearm magazine comprising a maximum number of N rounds. The magazine may comprise a follower, magnets on the follower, and <N magnetic-field-sensing sensors arranged along a path of the magnets when the follower moves along a length of the magazine, the sensors generating round count data based on a position of the one or more magnets relative to the <N magnetic-field-sensing sensors, and a first substantially flat antenna arranged on an inside of the magazine and configured to wirelessly transmit a round count indication to a second substantially flat antenna on the firearm, the round count indication based on the round count data, the second substantially flat antenna affixed to an inside of a magazine well of the firearm and mostly overlapping with the first substantially flat antenna.

Abstract: This disclosure describes systems, methods, and apparatus for detecting and displaying a number of rounds in a firearm magazine comprising a maximum number of N rounds. The magazine may comprise a follower, magnets on the follower, and <N magnetic switches arranged along a path of the magnets when the follower moves along a length of the magazine, the switches configured to activate based on a magnetic field exceeding a threshold, and a first antenna arranged on an inside of the magazine and parallel to a firing direction of the firearm, and configured to wirelessly transmit a round count indication to a second antenna on the firearm, the round count indication based on the round count data, the second antenna affixed to an inside of a magazine well of the firearm and mostly overlapping with the first antenna.

Abstract: This disclosure describes systems, methods, and apparatus for detecting and displaying a number of rounds in a firearm magazine comprising a maximum number of N rounds. The magazine may comprise a follower, magnets on the follower, and <N magnetic-field-sensing sensors arranged along a path of the magnets when the follower moves along a length of the magazine, the sensors generating round count data based on a position of the one or more magnets relative to the <N magnetic-field-sensing sensors, and a first substantially flat antenna arranged on an inside of the magazine and configured to wirelessly transmit a round count indication to a second substantially flat antenna on the firearm, the round count indication based on the round count data, the second substantially flat antenna affixed to an inside of a magazine well of the firearm and mostly overlapping with the first substantially flat antenna.

Abstract: This disclosure describes systems, methods, and apparatus for detecting and displaying a number of rounds in a firearm magazine comprising a maximum number of N rounds. The magazine may comprise a follower, magnets on the follower, and <N magnetic-field-sensing sensors arranged along a path of the magnets when the follower moves along a length of the magazine, the sensors generating round count data based on a position of the one or more magnets relative to the <N magnetic-field-sensing sensors, and a first substantially flat antenna arranged on an inside of the magazine and configured to wirelessly transmit a round count indication to a second substantially flat antenna on the firearm, the round count indication based on the round count data, the second substantially flat antenna affixed to an inside of a magazine well of the firearm and mostly overlapping with the first substantially flat antenna.

Abstract: Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells, and methods of treating sensory transduction disorders associated with a genetic defect.

Abstract: Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells.