Patents by Inventor Jeffrey I. Joseph
Jeffrey I. Joseph has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11759114Abstract: An implantable extravascular pressure sensing system includes a cuff including a first brace portion affixed to a second brace portion and defining a longitudinal axis therebetween. The first brace portion defines a fluid chamber, the fluid chamber defining a recessed aperture. A first lateral restraint and a second lateral restraint are disposed between the first brace and the second brace, the first lateral restraint and the second lateral restraint being configured to be displaceable in a direction orthogonal to the longitudinal axis. A diaphragm is coupled to the fluid chamber and sealing the recessed aperture. A fluid is disposed within the fluid chamber for exhibiting a hydraulic pressure in communication with the diaphragm. A pressure sensor is coupled to the first brace portion, the pressure sensor being configured to measure a change in the hydraulic pressure when a force is imparted on the diaphragm.Type: GrantFiled: June 4, 2021Date of Patent: September 19, 2023Assignees: RTM Vital Signs LLC, Thomas Jefferson UniversityInventors: Josiah Verkaik, Jeffrey I Joseph
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Patent number: 11751771Abstract: An implantable extravascular pressure sensing system including a cuff having a first brace portion, a second brace portion, and a plurality of biasing members movably coupling the first brace portion and the second brace portion to each other, the first brace portion defining a fluid chamber, the fluid chamber defining a recessed aperture, a flexible diaphragm coupled to the fluid chamber and sealing the recessed aperture, a fluid disposed within the fluid chamber for exhibiting a hydraulic pressure in communication with the flexible diaphragm, and a pressure sensor coupled to the first brace portion, the pressure sensor being configured to measure a change in the hydraulic pressure when a force is imparted on the flexible diaphragm.Type: GrantFiled: May 28, 2019Date of Patent: September 12, 2023Assignees: RTM Vital Signs, LLC, Thomas Jefferson UniversityInventors: Josiah Verkaik, Jeffrey I. Joseph, Noud Van Helmond
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Publication number: 20230172481Abstract: A sensor module retaining device having a first portion, a second portion, and a third portion. The first portion defines an open loop that is sized and configured to contour around an outer surface of a blood vessel. The second portion is opposite the third portion and the second and third portions each extend distally away from the open loop and define an open channel therebetween. The second and third portions are contiguous with and converge inwards towards the first portion.Type: ApplicationFiled: November 30, 2022Publication date: June 8, 2023Inventors: Jeffrey I Joseph, Josiah Verkaik
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Publication number: 20230172552Abstract: A method of associating a sensor with a blood vessel includes providing a sensor defining a passage therethrough and at least partially encircling the outside wall of the blood vessel with at least a portion of the sensor. The method further includes compressing the passage through the sensor until a portion of the blood vessel is flattened and mechanically coupling a pressure/force transducer to the outside wall of the blood vessel in an area of vessel wall flattening.Type: ApplicationFiled: November 30, 2022Publication date: June 8, 2023Inventors: Jeffrey I Joseph, Josiah Verkaik, Denise Devine
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Publication number: 20230123995Abstract: A method of monitoring physiological conditions including an acoustic measurement device and a remote controller. The remove controller configured to measure physiological conditions; calculate absolute tidal volume, a direction of tidal volume, and a rate of change of tidal volume; correlate absolute tidal volume, a direction of tidal volume, and a rate of change of tidal volume to a risk score; calculate a direction trend and rate of change for each physiological condition; correlate the direction trend and rate of change for each physiological condition; detect predefined patterns in the direction trend and rate of change of the measured physiological condition at the predetermined interval; and generating at least one from the group consisting of an alert, an alarm, and a medical treatment if the risk score defined on the predefined scale exceeds a first predetermined risk score threshold and at least one predefined pattern is detected.Type: ApplicationFiled: December 15, 2022Publication date: April 20, 2023Inventors: Jeffrey I. JOSEPH, Noud Van HELMOND, Marc C. TORJMAN, Denise L. DEVINE, Nance K. DICCIANI, Channy LOEUM
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Patent number: 11529076Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.Type: GrantFiled: October 11, 2021Date of Patent: December 20, 2022Assignees: Thomas Jefferson University, RTM Vital Signs LLCInventors: Jeffrey I Joseph, Noud Van Helmond, Marc C Torjman, Denise L Devine, Nance K Dicciani, Channy Loeum
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Patent number: 11445924Abstract: An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through, the first portion being sized to be implanted substantially entirely within the blood vessel wall of the patient. A sensor module configured to measure a blood vessel blood pressure waveform is included, the sensor module having a proximal portion and a distal portion, the distal portion being insertable within the lumen and the proximal portion extending outward from the first open end.Type: GrantFiled: August 1, 2019Date of Patent: September 20, 2022Assignee: Thomas Jefferson UniversityInventor: Jeffrey I. Joseph
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Patent number: 11330987Abstract: An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through, the first portion being sized to be implanted substantially entirely within the blood vessel wall of the patient. A sensor module configured to measure a blood vessel blood pressure waveform is included, the sensor module having a proximal portion and a distal portion, the distal portion being insertable within the lumen and the proximal portion extending outward from the first open end.Type: GrantFiled: May 17, 2019Date of Patent: May 17, 2022Assignees: Thomas Jefferson University, RTM Vital Signs LLCInventors: Apurva Jain, Jeffrey I. Joseph, Nance Dicciani, Denise Devine, David Demmer
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Publication number: 20220022773Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.Type: ApplicationFiled: October 11, 2021Publication date: January 27, 2022Inventors: Jeffrey I JOSEPH, Noud Van HELMOND, Marc C TORJMAN, Denise L DEVINE, Nance K DICCIANI, Channy LOEUM
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Patent number: 11213225Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.Type: GrantFiled: May 5, 2021Date of Patent: January 4, 2022Assignees: Thomas Jefferson University, RTM Vital Signs LLCInventors: Jeffrey I Joseph, Noud Van Helmond, Marc C Torjman, Denise L Devine, Nance K Dicciani, Channy Loeum
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Publication number: 20210386831Abstract: The present invention provides rapid-acting insulin and insulin analogue formulations. The invention further provides delivery devices, particularly infusion sets, which allow for the rapid absorption of insulin and insulin analogues, as well as other active agents. Methods of using the insulin and insulin analogue formulations as well as the insulin delivery devices for treating subjects with diabetes mellitus are also provided.Type: ApplicationFiled: June 1, 2021Publication date: December 16, 2021Inventors: Jeffrey I. JOSEPH, Richard William BERENSON, Bruce FRANK, Michael A. WEISS, Thomas HATTIER, Gregory DUBÉ, Zhiqiang CHEN
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Publication number: 20210378524Abstract: An implantable extravascular pressure sensing system includes a cuff including a first brace portion affixed to a second brace portion and defining a longitudinal axis therebetween. The first brace portion defines a fluid chamber, the fluid chamber defining a recessed aperture. A first lateral restraint and a second lateral restraint are disposed between the first brace and the second brace, the first lateral restraint and the second lateral restraint being configured to be displaceable in a direction orthogonal to the longitudinal axis. A diaphragm is coupled to the fluid chamber and sealing the recessed aperture. A fluid is disposed within the fluid chamber for exhibiting a hydraulic pressure in communication with the diaphragm. A pressure sensor is coupled to the first brace portion, the pressure sensor being configured to measure a change in the hydraulic pressure when a force is imparted on the diaphragm.Type: ApplicationFiled: June 4, 2021Publication date: December 9, 2021Inventors: Josiah Verkaik, Jeffrey I. Joseph
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Publication number: 20210251520Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.Type: ApplicationFiled: May 5, 2021Publication date: August 19, 2021Inventors: Jeffrey I JOSEPH, Noud Van HELMOND, Marc C TORJMAN, Denise L DEVINE, Nance K DICCIANI, Channy LOEUM
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Patent number: 11071476Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.Type: GrantFiled: August 22, 2019Date of Patent: July 27, 2021Assignees: Thomas Jefferson University, RTM Vital Signs LLCInventors: Jeffrey I Joseph, Noud Van Helmond, Marc C Torjman, Denise L Devine, Nance K Dicciani, Channy Loeum
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Publication number: 20210212574Abstract: An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through, the first portion being sized to be implanted substantially entirely within the blood vessel wall of the patient. A sensor module configured to measure a blood vessel blood pressure waveform is included, the sensor module having a proximal portion and a distal portion, the distal portion being insertable within the lumen and the proximal portion extending outward from the first open end.Type: ApplicationFiled: March 29, 2021Publication date: July 15, 2021Inventors: Jeffrey I. JOSEPH, Apurva JAIN, Jonathan GOETTLER, Nance DICCIANI, Denise DEVINE
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Patent number: 11006863Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.Type: GrantFiled: February 27, 2020Date of Patent: May 18, 2021Assignees: Thomas Jefferson University, RTM Vital Signs LLCInventors: Jeffrey I Joseph, Noud Van Helmond, Marc C Torjman, Denise L Devine, Nance K Dicciani, Channy Loeum
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Patent number: 11000191Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.Type: GrantFiled: July 24, 2020Date of Patent: May 11, 2021Assignees: Thomas Jefferson University, RTM Vital Signs LLCInventors: Jeffrey I Joseph, Marc C Torjman, Denise L Devine, Nance K Dicciani, Channy Loeum
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Patent number: 11000212Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.Type: GrantFiled: August 18, 2020Date of Patent: May 11, 2021Assignees: Thomas Jefferson University, RTM Vital Signs LLCInventors: Jeffrey I Joseph, Noud Van Helmond, Marc C Torjman, Denise L Devine, Nance K Dicciani, Channy Loeum
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Patent number: 11000195Abstract: An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through, the first portion being sized to be implanted substantially entirely within the blood vessel wall of the patient. A sensor module configured to measure a blood vessel blood pressure waveform is included, the sensor module having a proximal portion and a distal portion, the distal portion being insertable within the lumen and the proximal portion extending outward from the first open end.Type: GrantFiled: November 17, 2016Date of Patent: May 11, 2021Assignees: Thomas Jefferson University, RTM Vital Signs LLCInventors: Jeffrey I. Joseph, Apurva Jain, Jonathan Goettler, Nance Dicciani, Denise Devine
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Patent number: 10881330Abstract: A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.Type: GrantFiled: August 19, 2019Date of Patent: January 5, 2021Assignees: Thomas Jefferson University, RTM Vital Signs LLCInventors: Jeffrey I Joseph, Noud Van Helmond, Marc C Torjman, Denise L Devine, Nance K Dicciani, Channy Loeum