Patents by Inventor Jeffrey K. Harrison

Jeffrey K. Harrison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION THERAPY USING A CHEMOKINE RECEPTOR 2 (CCR2) ANTAGONIST AND A PD-1 AND/OR PD-L1 INHIBITOR
    Publication number: 20230404986
    Abstract: The present disclosure is drawn to the combination therapy of a Chemokine Receptor 2 (CCR2) antagonist and a PD-1 and/or PD-L1 inhibitor in the treatment of a central nervous system cancer.
    Type: Application
    Filed: May 3, 2023
    Publication date: December 21, 2023
    Inventors: James J. CAMPBELL, Rajinder SINGH, Jeffrey K. HARRISON
  • Combination Therapy Using a Chemokine Receptor 2 (CCR2) Antagonist and a PD-1 and/or PD-L1 Inhibitor
    Publication number: 20200297708
    Abstract: The present disclosure is drawn to the combination therapy of a Chemokine Receptor 2 (CCR2) antagonist and a PD-1 and/or PD-L1 inhibitor in the treatment of a central nervous system cancer.
    Type: Application
    Filed: March 19, 2020
    Publication date: September 24, 2020
    Inventors: James J. CAMPBELL, Rajinder SINGH, Samuel HWANG, Xueson WU, Jeffrey K. HARRISON
  • Cloning of a gene encoding for the growth hormone releasing hormone receptor
    Patent number: 5644046
    Abstract: Growth hormone releasing hormone (GHRH) receptor binding has been characterized using a unique binding assay utilizing iodinated GHRH probes. Photoaffinity GHRH probes have been constructed which allow for photolabeling and characterization of the receptor. In addition, high affinity biotinylated GHRH analogs have been constructed. Solubilization of GHRH-R/GHRH complexes and extraction of specifically bound GHRH using a mild detergent solution, followed by affinity chromatography, leads to a substantially purified GHRH-R isolate. Electrophoretic treatment of the GHRH-R isolate produces GHRH-R of sufficient purity to conduct sequencing of the receptor. Cloning of a gene encoding for polypeptides (protein or fragments thereof) having GHRH-R activity is accomplished using a bacterial host, and the cloned gene is expressed in a mammalian cell line.
    Type: Grant
    Filed: May 1, 1995
    Date of Patent: July 1, 1997
    Assignee: The University of Virginia Patent Foundation
    Inventors: Michael Oliver Thorner, Bruce David Gaylinn, Jeffrey K. Harrison, Kevin R. Lynch, John Ronald Zysk
  • Nucleic acid encoding the growth hormone releasing hormone receptor
    Patent number: 5612470
    Abstract: Growth hormone releasing hormone (GHRH) receptor binding has been characterized using a unique binding assay utilizing iodinated GHRH probes. Photoaffinity GHRH probes have been constructed which allow for photolabeling and characterization of the receptor. In addition, high affinity biotinylated GHRH analogs have been constructed. Solubilization of GHRH-R/GHRH complexes and extraction of specifically bound GHRH using a mild detergent solution, followed by affinity chromotography, leads to a substantially purified GHRH-R isolate. Electrophoretic treatment of the GHRH-R isolate produces GHRH-R of sufficient purity to conduct sequencing of the receptor. Cloning of a gene encoding for polypeptides (protein or fragments thereof) having GHRH-R activity is accomplished using a bacterial host, and the cloned gene is expressed in a mammalian cell line.
    Type: Grant
    Filed: September 18, 1992
    Date of Patent: March 18, 1997
    Assignees: American Cyanamid Company, The University of Virginia Patent Foundation
    Inventors: Michael O. Thorner, Bruce D. Gaylinn, John R. Zysk, Kevin R. Lynch, Jeffrey K. Harrison
  • Nucleic acid encoding the growth hormone releasing hormone receptor
    Patent number: 5591641
    Abstract: Growth hormone releasing hormone (GHRH) receptor binding has been characterized using a unique binding assay utilizing iodinated GHRH probes. Photoaffinity GHRH probes have been constructed which allow for photolabeling and characterization of the receptor. In addition, high affinity biotinylated GHRH analogs have been constructed. Solubilization of GHRH-R/GHRH complexes and extraction of specifically bound GHRH using a mild detergent solution, followed by affinity chromotography, leads to a substantially purified GHRH-R isolate. Electrophoretic treatment of the GHRH-R isolate produces GHRH-R of sufficient purity to conduct sequencing of the receptor. Cloning of a gene encoding for polypeptides (protein or fragments thereof) having GHRH-R activity is accomplished using a bacterial host, and the cloned gene is expressed in a mammalian cell line.
    Type: Grant
    Filed: September 15, 1992
    Date of Patent: January 7, 1997
    Assignees: American Cyanamid Company, The University of Virginia Patent Foundation
    Inventors: Michael O. Thorner, Bruce D. Gaylinn, John R. Zysk, Kevin R. Lynch, Jeffrey K. Harrison
  • Nucleic acid molecule encoding the porcine growth hormone receptor
    Patent number: 5583010
    Abstract: Growth hormone releasing hormone (GHRH) receptor binding has been characterized using a unique binding assay utilizing iodinated GHRH probes. Photoaffinity GHRH probes have been constructed which allow for photolabeling and characterization of the receptor. In addition, high affinity biotinylated GHRH analogs have been constructed. Solubilization of GHRH-R/GHRH complexes and extraction of specifically bound GHRH using a mild detergent solution, followed by affinity chromotography, leads to a substantially purified GHRH-R isolate. Electrophoretic treatment of the GHRH-R isolate produces GHRH-R of sufficient purity to conduct sequencing of the receptor. Cloning of a gene encoding for polypeptides (protein or fragments thereof) having GHRH-R activity is accomplished using a bacterial host, and the cloned gene is expressed in a mammalian cell line.
    Type: Grant
    Filed: June 10, 1993
    Date of Patent: December 10, 1996
    Assignees: American Cyanamid Company, The University of Virginia Patent Foundation
    Inventors: William R. Baumbach, John R. Zysk, Michael O. Thorner, Bruce D. Gaylinn, Kevin R. Lynch, Jeffrey K. Harrison