Abstract: This disclosure is based, at least in part, on an unexpected discovery that the novel nanobodies and variants thereof are able to specifically bind afucosylated or sialylated IgG Fc glycoforms. Glycosylation of the IgG Fc domain is a major determinant of the strength and specificity of antibody effector functions, modulating the binding interactions of the Fc with the diverse family of Fc? receptors. These Fc glycan modifications, such as removal of the core fucose residue, are newfound clinical markers for predicting severity of diseases, such as diseases caused by dengue virus (DENV) or SARS-CoV-2. However, it remains challenging to accurately distinguish specific IgG glycoforms without costly and time-intensive methods. The novel glycol-specific nanobodies and variants thereof, as disclosed herein, can be used as rapid clinical diagnostics or prognostics to risk stratify patients with viral and inflammatory diseases.

Abstract: A system (20) and method are disclosed for the self-calibrating, on-line determination of size distribution f(x) and volume fraction ? of a number of particles (P) dispersed in a medium (M) by detecting one or more propagation characteristics of multiply scattered light from the particles (P). The multiply scattered light is re-emitted in response to exposure to a light source (21) configured to provide light at selected wavelengths. The determination includes calculating the isotropic scattering and absorption coefficients for the particles (P) by comparing the incident and detected light to determine a measurement corresponding to the propagation time through the scattering medium (M), and iteratively estimating the size distribution f(x) and volume fraction ? as a function of the coefficients for each of the wavelengths. An estimation approach based on an expected form of the distribution and the mass of the particles is also disclosed.

Abstract: A heat sink includes a heat dissipating body having a visible outer surface, and a thermo-chromic dye coated on the visible outer surface of the heat dissipating body. The thermo-chromic dye is capable of changing color in response to temperature change of the heat dissipating body. In addition, a power supply includes a housing having a visible outer surface, and a thermo-chromic dye coated on the visible outer surface of the housing. The thermo-chromic dye is capable of changing color in response to temperature change of the housing.

Abstract: A method for preventing a BIOS from getting viruses, wherein a changeable memory for storing BIOS codes is divided into two areas, one is a primary actuating area and other is a duplicating area. Initially these two areas store identical BIOS. The method comprises the steps of actuating from the primary actuating area and determining whether the step of actuating exists; performing the process to a testing point, and comparing the check sums of the primary actuating area and the duplicating area; through the comparison, performing the starting up process from the primary actuating area and duplicating area and copying the data of the primary actuating area and duplicating area to one another to maintain one area having a complete BIOS in order to prevent the BIOS from being destroyed by virus, or by abnormal modification, so that the system operates normally.

Abstract: The invention provides a method of automatically overclocking CPUs for a computer system by using a frequency generator with functions of tuning frequency and monitoring, and applying a numeric method to get the frequency for booting a computer system. When a computer system is powered on and enters the overclocking process, the built-in parameters storing booting settings are loaded and backed up to be referenced in the next trial of booting. The frequency of overclocking is calculated by a numeric method according to the highest frequency generated by the frequency generator and the frequency of front side bus of the system. The built-in parameters are then stored to boot up a computer system at next time. Once the configuration of the computer system is changed, the values of parameters are invalid and need to be recalculated by entering the overclocking process. Using this automatic method, overclocking can be done in a shorter time than overclocking manually.