Patents by Inventor Jeffrey Karg
Jeffrey Karg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130193226Abstract: One embodiment includes a dispenser device and container for mixing a chemical concentrate and a diluent to produce a diluted mixture. The dispenser device may include a housing, a slide, and an eductor. The container holds the chemical concentrate. The dispenser device communicates with the chemical concentrate and with the diluent.Type: ApplicationFiled: March 9, 2011Publication date: August 1, 2013Applicant: Woods Dispensing Systems, LLCInventors: Robert C. Uschold, Jeffrey A. Karg, Christopher M. Catinella, Vito Lore
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Publication number: 20120240925Abstract: A dose counter for counting does of medicament dispensed by or remaining in a metered-dose inhaler. The dose counter includes a rotatably mounted gear wheel having a circular arrangement of ratchet teeth defining a root circle and a display coupled to the gear wheel, the display having a visible array of dose counting indicia indexable in response to rotary motion of the gear wheel. The dose counter further includes an actuator mechanism having a driver for rotatably driving the gear wheel in response to the dispensation of a medicament dose, the driver being arranged to engage the ratchet teeth of the gear wheel. The actuator mechanism includes an actuator shaft mounted for linear movement in response to the dispensing of a dose of medicament. In use, the travel of the driver along the root circle of the gear wheel exceeds the corresponding linear movement of the actuator shaft.Type: ApplicationFiled: July 28, 2010Publication date: September 27, 2012Applicant: IVAX INTERNATIONAL B.V.Inventors: Simon G. Kaar, Jeffrey A. Karg, Timothy Norman Johnson, Robert Charles Uschold
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Publication number: 20120241526Abstract: A dose counter for counting doses of medicament dispensed by or remaining in a metered-dose inhaler. The dose counter includes: a rotatably mounted gear wheel having a circular arrangement of ratchet teeth; a display coupled to the gear wheel, the display having a visible array of dose counting indicia indexable in response to rotary motion of the gear wheel; and an actuator mechanism having a driver for rotatably driving the gear wheel in response to the dispensation of a medicament dose, the driver being arranged to engage the ratchet teeth of the gear wheel. The actuator mechanism includes a pivotally mounted lever having an input portion. The lever is arranged to amplify a linear stroke at the input portion such that a linear stroke of the driver exceeds the linear input stroke. By amplifying the stroke, the risk of undercounting due to insufficient stroke length may be reduced.Type: ApplicationFiled: July 28, 2010Publication date: September 27, 2012Applicant: IVAX International B.V.Inventors: Simon G. Kaar, Jeffrey A. Karg, Timothy Norman Johnson, Robert Charles Uschold
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Publication number: 20120240926Abstract: A dose counter for counting doses of medicament dispensed by or remaining in a metered-dose inhaler. The dose counter includes a rotatably mounted first gear wheel having ratchet teeth and a display coupled to the first gear wheel, the display having a visible array of dose counting indicia indexable in response to rotary motion of the first gear wheel. The dose counter further includes an actuator mechanism having a first ratchet drive pawl for engaging the ratchet teeth of the first gear wheel in response to the dispensation of a medicament dose, and a second ratchet drive pawl for engaging the ratchet teeth of a gear wheel coupled to the display. In use, a first ratchet tooth of the first gear wheel is rotatably driven by the first pawl and then a second ratchet tooth of the gear wheel coupled to the display is rotatably driven by the second pawl.Type: ApplicationFiled: July 28, 2010Publication date: September 27, 2012Applicant: Ivax InternationalInventors: Simon G. Kaar, Jeffrey A. Karg, Timothy Norman Johnson, Robert Charles Uschold
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Patent number: 8080218Abstract: A device and method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the sample liquid, and to retain the collected dose by capillary force when the channel is emptied. The sample liquid is then removed from the channel under conditions that enable retention of the collected, metered dose of the sample liquid in the pocket. Following a cleaning step, a volume of diluent liquid is introduced into the channel to induce diffusion and mixing of the diluent liquid with the dose of sample liquid to form a mixture.Type: GrantFiled: September 21, 2009Date of Patent: December 20, 2011Assignee: Molecular Bio-Products, Inc.Inventors: Jeffrey A. Karg, Douglas W. Kroncke
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Publication number: 20110283997Abstract: A manually operated metered dose inhaler includes a dose counter chamber including a dose display tape driven by a ratchet wheel which is driven in turn by an actuator pawl actuated by movement of a canister, the tape unwinding from a stock bobbin during use of the inhaler, a rotation regulator being provided for the stock bobbin and including a wavelike engagement surface with concavities which engage against control elements in the form of protrusions on resilient forks of a split pin thereby permitting incremental unwinding of the stock bobbin yet resisting excessive rotation if the inhaler is dropped onto a hard surface.Type: ApplicationFiled: May 18, 2011Publication date: November 24, 2011Applicants: IVAX PHARMACEUTICALS IRELAND (a trading name of IVAX International B.V.), TEVA PHARMACEUTICALS IRELAND (a trading name of IVAX International B.V.), NORTON WATERFORD (a trading name of IVAX International B.V.)Inventors: Declan Walsh, Derek Fenlon, Simon Kaar, Jan Geert Hazenberg, Dan Buck, Paul Clancy, Robert Charles Uschold, Jeffrey A. Karg
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Patent number: 8043865Abstract: A device and method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the sample liquid, and to retain the collected dose by capillary force when the channel is emptied. The sample liquid is then removed from the channel under conditions that enable retention of the collected, metered dose of the sample liquid in the pocket. Following a cleaning step, a volume of diluent liquid is introduced into the channel to induce diffusion and mixing of the diluent liquid with the dose of sample liquid to form a mixture.Type: GrantFiled: September 1, 2010Date of Patent: October 25, 2011Assignee: Molecular BioProducts, Inc.Inventors: Jeffrey A. Karg, Douglas W. Kroncke
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Publication number: 20110027906Abstract: A device and method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the sample liquid, and to retain the collected dose by capillary force when the channel is emptied. The sample liquid is then removed from the channel under conditions that enable retention of the collected, metered dose of the sample liquid in the pocket. Following a cleaning step, a volume of diluent liquid is introduced into the channel to induce diffusion and mixing of the diluent liquid with the dose of sample liquid to form a mixture.Type: ApplicationFiled: September 1, 2010Publication date: February 3, 2011Inventors: Jeffrey A. Karg, Douglas W. Kroncke
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Publication number: 20100008827Abstract: A device and method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the sample liquid, and to retain the collected dose by capillary force when the channel is emptied. The sample liquid is then removed from the channel under conditions that enable retention of the collected, metered dose of the sample liquid in the pocket. Following a cleaning step, a volume of diluent liquid is introduced into the channel to induce diffusion and mixing of the diluent liquid with the dose of sample liquid to form a mixture.Type: ApplicationFiled: September 21, 2009Publication date: January 14, 2010Inventors: Jeffrey A. Karg, Douglas W. Kroncke
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Patent number: 7592185Abstract: A method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the sample liquid, and to retain the collected dose by capillary force when the channel is emptied. The sample liquid is then removed from the channel under conditions that enable retention of the collected, metered dose of the sample liquid in the pocket. Following a cleaning step, a volume of diluent liquid is introduced into the channel to induce diffusion and mixing of the diluent liquid with the dose of sample liquid to form a mixture.Type: GrantFiled: August 5, 2004Date of Patent: September 22, 2009Assignee: Molecular BioProducts, Inc.Inventors: Jeffrey A. Karg, Douglas W. Kroncke
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Publication number: 20080302178Abstract: A method and system for dispensing small volumes of liquid reagents is provided. The system includes a sequence of one, two, or three or more sensors, attached to a conduit, which send an electronic signal indicating the presence or lack of fluid in the conduit. The sensors can sense the leading edge of a fluid in a conduit, often called the leading meniscus. The sensors are connected to a microprocessor capable of recording the time the leading meniscus passes each sensor. The microprocessor can also calculate the time difference between the sensors, and at a constant flow rate, determine the speed of the fluid in the conduit and proportionally, depending on the diameter of the conduit, calculate the flow rate within the conduit. The microprocessor can also control the pump to cause the fluid to flow for a specific period of time so that a known discrete volume can be dispensed from the conduit.Type: ApplicationFiled: June 10, 2008Publication date: December 11, 2008Inventor: Jeffrey Karg
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Patent number: 7459128Abstract: A microfluidic dispensing tap, such as for use in screening assays, includes a dispensing tube translatable within a sealed reservoir housing. The tube has an outer surface and defines an inner cavity open at a lower end of the tube, and a metering aperture extending through a side wall of the tube between the inner cavity and the outer surface to define a known volume. The tube is movable against a seal at a lower end of the reservoir housing between a first position, in which the metering aperture is disposed below the seal, and a second position, in which the metering aperture is disposed above the seal and exposed to the reservoir for entraining a discrete dose of a sample liquid within the aperture. An injector is configured to inject a known quantity of a diluent into the inner cavity of the tube and into fluidic contact with the dose of sample liquid in the aperture, such that the dose of sample liquid diffuses into the diluent to form a discrete mixture for dispensing from an open end of the tube.Type: GrantFiled: February 13, 2004Date of Patent: December 2, 2008Assignee: Molecular BioProducts, Inc.Inventors: Jeffrey A. Karg, Douglas W. Kroncke
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Publication number: 20080152515Abstract: A pump for pumping discrete liquid volumes is provided with an anti-rotation construction to prevent a nut mated to a rotating head screw from rotating when the lead screw is rotated. The anti-rotation construction comprises a set of rails that slideably fit within a mating set of tracks. The pump also can include a variable homing position for a pump piston having at least two different homing positions.Type: ApplicationFiled: December 10, 2007Publication date: June 26, 2008Inventors: Jeffrey A. Karg, Paul Simonetti, Vanessa Kollars
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Publication number: 20050181519Abstract: A method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the sample liquid, and to retain the collected dose by capillary force when the channel is emptied. The sample liquid is then removed from the channel under conditions that enable retention of the collected, metered dose of the sample liquid in the pocket. Following a cleaning step, a volume of diluent liquid is introduced into the channel to induce diffusion and mixing of the diluent liquid with the dose of sample liquid to form a mixture.Type: ApplicationFiled: August 5, 2004Publication date: August 18, 2005Inventors: Jeffrey Karg, Douglas Kroncke
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Publication number: 20040208794Abstract: A microfluidic dispensing tap, such as for use in screening assays, includes a dispensing tube translatable within a sealed reservoir housing. The tube has an outer surface and defines an inner cavity open at a lower end of the tube, and a metering aperture extending through a side wall of the tube between the inner cavity and the outer surface to define a known volume. The tube is movable against a seal at a lower end of the reservoir housing between a first position, in which the metering aperture is disposed below the seal, and a second position, in which the metering aperture is disposed above the seal and exposed to the reservoir for entraining a discrete dose of a sample liquid within the aperture. An injector is configured to inject a known quantity of a diluent into the inner cavity of the tube and into fluidic contact with the dose of sample liquid in the aperture, such that the dose of sample liquid diffuses into the diluent to form a discrete mixture for dispensing from an open end of the tube.Type: ApplicationFiled: February 13, 2004Publication date: October 21, 2004Inventors: Jeffrey A. Karg, Douglas W. Kroncke
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Patent number: 6706538Abstract: Devices and methods for integrated packaging, shipping, storage and precise dispensing of extremely small volumes of liquids such as aqueous solutions and compounds dissolved in organic solvents are disclosed. Devices of the invention include a sealed reservoir with an integrated metering tap. The tap includes a metering tube, which is translatable between a fill position inside the reservoir and an expel position outside the reservoir. The metering tube includes: (1) a tube end closure in a lower portion of the tube, (2) a port above the tube end closure, and (3) a piston in an upper portion of the tube. The piston is movable between a down position that seals the side port and an up position above the port. Movement of the piston from the up position to the down position can displace from 10 nanoliters to 20 microliters, e.g., from 20 nanoliters to 2 microliters, or 50 nanoliters to 500 nanoliters.Type: GrantFiled: June 12, 2000Date of Patent: March 16, 2004Assignee: Boston Innovation Inc.Inventors: Jeffrey A. Karg, Douglas W. Kroncke, Michael J. Jobin
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Patent number: 6620383Abstract: Devices and methods for integrated packaging, shipping, storage and precise dispensing of extremely small volumes of liquids such as aqueous solutions and compounds dissolved in organic solvents are disclosed. Devices of the invention include a sealed reservoir with an integrated metering tap. The tap includes a metering tube, which is translatable between a fill position inside the reservoir and an expel position outside the reservoir. The metering tube includes: (1) a tube end closure in a lower portion of the tube, (2) a port above the tube end closure, and (3) a piston in an upper portion of the tube. The piston is movable between a down position that seals the side port and an up position above the port. Movement of the piston from the up position to the down position can displace from 10 nanoliters to 20 microliters, e.g., from 20 nanoliters to 2 microliters, or 50 nanoliters to 500 nanoliters.Type: GrantFiled: June 12, 2000Date of Patent: September 16, 2003Assignee: Boston Innovation Inc.Inventors: Jeffrey A. Karg, Douglas W. Kroncke
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Patent number: 6516953Abstract: A device and method is provided for separating components of a fluid sample. The device includes a plurality of constituents comprising a container, a liner in the container, a closure for the container and a composite element. The composite element is a seal plug with a density between the densities of the components of the fluid sample is releasably engaged with the container closure and with the liner. A needle cannula is used to deposit a fluid sample in the liner and the entire device is placed in a centrifuge. The centrifugal load causes the seal plug to separate from the closure and causes the liner to expand outwardly against the container. The seal plug migrates into the fluid sample and stabilizes between the densities of the components of the fluid sample. The liner will resiliently return to its initial configuration upon termination of centrifugal load such that the liner sealingly engages the seal plug and separates the components of the fluid sample.Type: GrantFiled: December 2, 1999Date of Patent: February 11, 2003Assignee: Becton, Dickinson and CompanyInventors: Paul C. DiCesare, Jeffrey Karg, Fu-Chung Lin, Jeffrey P. Radziunas
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Patent number: 6497325Abstract: A device and method is provided for separating heavier and lighter fractions of a fluid sample. The device includes a plurality of constituents. The constituents include a container, a liner in the container and a composite element in the liner for separating the fractions of a fluid sample. The separator comprises a specific density at a target density range as defined by separable fluid components densities. A fluid sample is delivered to the liner and then the device is subjected to centrifugation whereby the centrifugal load causes the liner to deform and the composite element migrates into the fluid sample and stabilizes between the heavier and lighter fractions of the fluid sample. The liner will resiliently return to its initial configuration upon termination of the centrifugal load such that the liner sealingly engages the composite element and separates the heavier and lighter fractions of the fluid sample.Type: GrantFiled: December 3, 1999Date of Patent: December 24, 2002Assignee: Becton Dickinson and CompanyInventors: Paul DiCesare, Jeffrey Karg, Fu-Chung Lin
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Patent number: 6479298Abstract: A device and method for separating heavier and lighter fractions of a fluid sample. The device includes a plurality of constituents comprising a container and a composite element in the container. The composite element is a separator comprising at least two components and more particularly, a bellows with a seal body, a low-density float and a high-density ballast. A fluid sample is delivered to the container and the device is subjected to centrifugation whereby the centrifugal load causes the seal body of the separator to deform so that the separator migrates through the fluid sample and then stabilizes between the heavier and lighter fractions of the fluid sample. The seal body of the separator will resiliently return to its initial configuration upon termination of the centrifugal load such that the seal body sealingly engages the container and the composite element separates the heavier and lighter fractions of the fluid sample.Type: GrantFiled: December 3, 1999Date of Patent: November 12, 2002Assignee: Becton, Dickinson and CompanyInventors: Henry F. Miller, Fu-Chung Lin, Robert J. Losada, Jeffrey P. Radziunas, Jeffrey Karg