Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.

Abstract: A compression system endwall bleed system having a plurality of bleed slots formed in a mechanical housing downstream of a rotating shrouded rotor. In one embodiment, the plurality of bleed slots bleed off a separated tip boundary layer to relieve back pressure associated with this blockage. A sealing structure downstream of the shrouded rotor is utilized to minimize working fluid leakage ahead of the plurality of bleed slots.