Abstract: An optoacoustic probe for optoacoustic imaging of a volume is provided that includes a housing extending from a distal end operable to contact the volume to a proximal end. The optoacoustic probe includes a light source configured to generate light that is transmitted along a light pathway to generate return signals when the light reacts with the volume, and a transducer assembly including a transducer configured to receive the optoacoustic return signals and an acoustic lens provided over the transducer. The optoacoustic probe also includes a steering assembly coupled within the housing and configured to steer the light pathway to generate the light along the light pathway at different scanning areas of the volume based on the return signals.

Abstract: An optoacoustic probe for optoacoustic imaging of a volume, the optoacoustic probe having a distal end operable to contact the volume and a proximal end. The optoacoustic probe includes at least one primary light source and an auxiliary light source that is configured to generate auxiliary light carried through an optical window to a volume. A detection device is configured to detect signals generated from the auxiliary light or primary light reflecting from the volume or the optical window. A microcontroller including one or more processors is also provided, that receives the signals generated from the auxiliary light reflecting from the volume from the detection device, determines contact between the volume and the optoacoustic probe based on the auxiliary light reflecting from the volume, and prevents the at least one primary light source from generating light until the optoacoustic probe is contacting the volume.

Abstract: An optoacoustic probe for optoacoustic imaging of a volume, the optoacoustic probe having a distal end operable to contact the volume and a proximal end. The optoacoustic probe includes at least one primary light source and an auxiliary light source that is configured to generate auxiliary light carried through an optical window to a volume. A detection device is configured to detect signals generated from the auxiliary light or primary light reflecting from the volume or the optical window. A microcontroller including one or more processors is also provided, that receives the signals generated from the auxiliary light reflecting from the volume from the detection device, determines contact between the volume and the optoacoustic probe based on the auxiliary light reflecting from the volume, and prevents the at least one primary light source from generating light until the optoacoustic probe is contacting the volume.

Abstract: An optoacoustic probe for optoacoustic imaging of a volume, the optoacoustic probe having a distal end operable to contact the volume and a proximal end. The optoacoustic probe includes at least one primary light source and an auxiliary light source that is configured to generate auxiliary light carried through an optical window to a volume. A detection device is configured to detect signals generated from the auxiliary light or primary light reflecting from the volume or the optical window. A microcontroller including one or more processors is also provided, that receives the signals generated from the auxiliary light reflecting from the volume from the detection device, determines contact between the volume and the optoacoustic probe based on the auxiliary light reflecting from the volume, and prevents the at least one primary light source from generating light until the optoacoustic probe is contacting the volume.

Abstract: A hybrid tissue scaffold is provided which comprises a porous primary scaffold having a plurality of pores and a porous secondary scaffold having a plurality of pores, wherein the secondary scaffold resides in the pores of the primary scaffold to provide a hybrid scaffold. The pores of the porous primary scaffold may have a pore size in a range of 0.50 mm to 5.0 mm, and the pores of the porous secondary scaffold may have a pore size in a range of 50 ?m to 600 ?m. The primary scaffold may provide 5% to 30% of a volume of the hybrid scaffold.

Abstract: A hybrid tissue scaffold is provided which comprises a porous primary scaffold having a plurality of pores and a porous secondary scaffold having a plurality of pores, wherein the secondary scaffold resides in the pores of the primary scaffold to provide a hybrid scaffold. The pores of the porous primary scaffold may have a pore size in a range of 0.50 mm to 5.0 mm, and the pores of the porous secondary scaffold may have a pore size in a range of 50 ?m to 600 ?m. The primary scaffold may provide 5% to 30% of a volume of the hybrid scaffold.