Abstract: Stents and other medical devices that can have specific geometric configurations (curves, contours, tapers) and/or patterns (e.g., grooves) thereon, methods of making such medical devices, and apparatuses for making such medical devices are disclosed. Projection photolithography is used to define patterns the medical devices. The methods can form grooves, ridges, channels, holes, wells, and other geometric patterns (e.g. parallelograms such as squares, rectangles and other trapezoids; triangles, pentagons, spirals, hexagons, etc.) on the surface of both the inner and outer diameters (e.g., on both the inner and outer surfaces) of stents or other cylindrical, tubular or curved-surface medical devices, allowing the manufacture of stents having customized geometry/contours on all surfaces, which can minimize endothelial surface disruption of blood flow.

Abstract: Disclosed herein are endoluminal implants for bioactive material delivery. The disclosed endoluminal implants come in the general forms of patches and sleeves and can deliver bioactive materials independently of other implantable medical devices such as stents.

Abstract: A method for delivering a therapeutic agent to a predetermined location in a host is disclosed, wherein a liposome-encapsulated therapeutic agent is administered to the host, and an electrical field which encompasses a predetermined region within the host is established, such that as the liposome-encapsulated agent is exposed to the electrical field the release of the agent from the liposome to the predetermined region is enhanced.

Abstract: A method for inhibiting or suppressing stenosis associated with an arteriovenous access. A dosage of photosensitive compound is introduced into the artery or vein. An anastomotic area of the artery or vein is then exposed to a source of light having a wavelength suitable for photoactivating the photosensitive compound for a period of time sufficient to provide a therapeutic effect. A method is also described for the delivery of drugs into the anastomotic site of an AV access to inhibit the formation of stenotic lesions at those sites.

Abstract: The invention relates to the site specific delivery of drugs in an organism. The described methods facilitate the delivery of a therapeutic or diagnostic drug by increasing vascular permeability in a site specific manner. Vascular permeability is enhanced in the disclosed methods by using a combination of a photosensitizer and radiation applied to a site of interest.

Abstract: A method for inhibiting or suppressing stenosis associated with an arteriovenous access. A dosage of photosensitive compound is introduced into the artery or vein. An anastomotic area of the artery or vein is then exposed to a source of light having a wavelength suitable for photoactivating the photosensitive compound for a period of time sufficient to provide a therapeutic effect. A method is also described for the delivery of drugs into the anastomotic site of an AV access to inhibit the formation of stenotic lesions at those sites.

Abstract: A method for delivering a therapeutic agent to a predetermined location in a host is disclosed, wherein a liposome-encapsulated therapeutic agent is administered to the host, and an electrical field which encompasses a predetermined region within the host is established, such that as the liposome-encapsulated agent is exposed to the electrical field the release of the agent from the liposome to the predetermined region is enhanced.