Patents by Inventor Jeffrey P. Whitten

Jeffrey P. Whitten has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel thione dopamine beta hydroxylase inhibitors
    Patent number: 5057613
    Abstract: Imidazole-2-thione derivatives useful as antihypertensive agents are described herein. The compounds are obtained by cyclization of an appropriate open-chain compound such as an appropriately substituted thiourea.
    Type: Grant
    Filed: October 27, 1987
    Date of Patent: October 15, 1991
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Donald P. Matthews, James R. McCarthy, Jeffrey P. Whitten, Robert J. Broersma, Jr.
  • Thiazolyl methyl)-2-2'-Bi-1H-imidazoles and use as hypertensive agents
    Patent number: 5017591
    Abstract: This invention relates to novel (aryl or heteroaromatic methyl)-2,2'-1H-biimidazoles; to a process for their production comprising of reacting an appropriate alpha-brominated or alpha-chlorinated, substituted or nonsubstituted, methylated monoaromatic ring compound with 2,2'-bi-1H-imidazole in a solvent such as ethanol in the presence of a base such as sodium hydroxide under reflux conditions; and to pharmaceutical compositions and methods of treating hypertension with such compounds.
    Type: Grant
    Filed: March 2, 1990
    Date of Patent: May 21, 1991
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Donald P. Matthews, Jeffrey P. Whitten, James B. McCarthy
  • Process for preparing heteroaromatic methyl)-2,2'-bi-1H-imidazoles
    Patent number: 4929744
    Abstract: This invention relates to a process for preparing (aryl) or heteroaromatic methyl)-2,2'-1H-biimidazoles. Reacting an appropriate alpha-brominated or alpha-chlorinated, substituted or non-substituted, methylated monoaromatic ring compound with 2,2'-bi-1H-imidazole in a solvent such as ethanol in the presence of a base such as sodium hydroxide under reflux conditions; and to pharmaceutical compositions and methods of treating hypertension with such compounds.
    Type: Grant
    Filed: March 27, 1989
    Date of Patent: May 29, 1990
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Donald P. Matthews, James R. McCarthy, Jeffrey P. Whitten
  • (Aryl or heteroaromatic methyl)-2,2'-bi-1H-imidazoles and their use as anti-hypertensive agents
    Patent number: 4839375
    Abstract: This invention relates to novel (aryl or heteroaromatic methyl)-2,2'-1H-biimidazoles; to a process for their production comprising of reacting an appropriate alpha-brominated or alpha-chlorinated, substituted or non-substituted, methylated monoaromatic ring compound with 2,2'-bi-1H-imidazole in a solvent such as ethanol in the presence of a base such as sodium hydroxide under reflux conditions; and to pharmaceutical compositions and methods of treating hypertension with such compounds.
    Type: Grant
    Filed: July 28, 1987
    Date of Patent: June 13, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Donald P. Matthews, Jeffrey P. Whitten, James R. McCarthy
  • Novel imidazole dopamine beta hydroxylase inhibitors
    Patent number: 4810800
    Abstract: 1,2-Disubstituted imidazoles useful as antihypertensive agents are described herein. The compounds are obtained from the appropriate 1-substituted imidazole which can be reacted with methyl oxalyl chloride to give the oxalyl derivative or it can be reacted with cyanogen chloride to give the 2-carbonitrile which can then be converted to the other derivatives desired.
    Type: Grant
    Filed: April 29, 1988
    Date of Patent: March 7, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Donald P. Matthews, James R. McCarthy, Jeffrey P. Whitten, Robert J. Broersma, Jr.