Abstract: Compounds of formula (I) Q-L-W—C(?X)-Z-P wherein Q is an amine of the formula —N(R1)(R2); L is an alkyl or heterocyclyl-alkyl linker; W is a 6- or 7-membered aliphatic ring comprising ring atoms Y1 and Y2 which are linked to groups L and C(X) respectively and Y1 and Y2 are independently selected from N and C; X is O, N, N—CN or S; Z is NR3; P is an optionally substituted monocyclic or bicyclic aryl or heteroaryl group; and pharmaceutically acceptable salts or solvates thereof, are useful in the treatment of C-C chemokine mediated conditions.

Abstract: The invention concerns the use of a quinazoline derivative of Formula (I) wherein Q1 includes a quinazoline ring optionally substituted with a group such as halogeno, trifluoromethyl and cyano, or a group of the formula: Q3—X1— wherein X1 includes a direct bond and O and Q3includes aryl, aryl-(1-6C)alkyl, heterocyclyl and heterocyclyl-(1-6C)alkyl; each of R2 and R3 is hydrogen or (1-6C)alkyl; Z includes O, S and NH; and Q2 includes aryl and aryl-(1-3C)alkyl or a pharmaceutically-acceptable salt thereof, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human.

Abstract: A compound of formula (I) P—W—C(?X)-L-Q ??(I) wherein P is an optionally substituted aryl or heteroaryl group; W is an optionally substituted 6 or 7-membered aliphatic ring comprising ring atoms Y1 and Y2 independently selected from Oxygen and Nitrogen, X is selected from Oxygen, Nitrogen and Sulphur; L is an optional C1-4 linker; and Q is an optionally substituted 4-7 membered aliphatic ring: for use in the treatment of chemokine mediated diseases or disorders.

Abstract: The present invention provides a buckle and frame for a restraint system resisting to a harsh environment. The buckle comprising a frame having a base wall, the base wall includes a debris exit opening; and a cover which encloses the frame and forms at least one vent opening and at least one passage which couples the debris exit opening to the vent opening. Debris, dust and other foreign objects which find there way into the buckle are not necessarily trapped but rather are presented with a means of exiting the buckle via the vent opening.

Abstract: The invention concerns quinazoline and quinoline derivatives of Formula (I) wherein Q1 includes a quinazoline or quinoline ring optionally substituted with a group such as halogeno, trifluoromethyl and cyano, or a group of the formula: Q3—X1— wherein X1 includes a direct bond and O and Q3 includes aryl, aryl-(1-6C)alkyl, heterocyclyl and heterocyclyl-(1-6C)alkyl; each of R2, R3 and R5 is hydrogen or (1-6C)alkyl, provides that one of the parts of groups R2 and R4 together, R3 and R4 together and R5 and R4 together forms a bond; R6 is an optionally substituted group selected from (2-6C) alkenyl, (2-6C) alkynyl, (3-7C)cycloalkyl and (3-7C) cycloalkenyl, or R6 is a substituted (1-6C) alkyl group; and Q2 includes aryl and aryl-(1-3C)alkyl or a pharmaceutically-acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the prevention or treatment of T cell mediated diseases or medical conditions in a warm-blooded

Abstract: In a television system in which at least program title information for programs which are to be transmitted in the future is transmitted in advance to form a channel guide listing, apparatus is provided for searching the listing for specific user-entered information, and upon successful conclusion to the search, the apparatus schedules the tuning of the desired program, or in the alternative, notifies the viewer of the availability of the program. In those instances where descriptive text accompanies the program listing, apparatus of the invention performs a search of the text for a particular text string which may relate to the title, the star, the director, or the context of the program, among other search criteria.

Abstract: A control system and calibration method are provided for a vehicle drive line having an automated master friction clutch. The control system utilizes engine torque data supplied by a serial communication data link to identify a clutch control parameter value corresponding to an urge-to-move position of the clutch. The clutch control parameter value identified by the calibration method is stored and utilized by the control system to control the engagement position of the automated clutch in an “urge to move” mode of operation. The inventive calibration method can be utilized across multiple vehicle platforms having different engine, clutch and transmission system components.

Abstract: The invention relates to thiophene carboxanmides of formula (I). wherein A, R1, R2, R3, n and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

Abstract: The invention concerns quinazoline derivatives of Formula (I) wherein Q1 includes a quinazoline ring optionally substituted with a group such as halogeno, trifluoromethyl and cyano, or a group of the formula: Q3—X1— wherein X1 includes a direct bond and O and Q3 includes aryl, aryl-(1-6C)alkyl, heterocyclyl and heterocyclyl-(1-6C)alkyl; each of R2 and R3 is hydrogen or (1-6C)alkyl; Z includes O, S and NH; and Q2 includes aryl and aryl-(1-3C)alkyl or a pharmaceutically-acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the prevention or treatment of T cell mediated diseases or medical conditions in a warm-blooded animal.

Abstract: A system for controlling apparatus processing a signal representing a television program comprises a source of schedule data comprising at least data representing the time remaining in a television program. Television signal processing apparatus selectively processes the television program representative signal in response to a control signal. A control circuit generates the control signal to condition the processing apparatus to begin processing the television program signal in response to a user control signal, and to stop processing the television program signal when the time remaining in the television program has elapsed, in response to the program schedule data.

Abstract: The invention concerns the use of a quinazoline derivative of Formula (I) wherein Q1 includes a quinazoline ring optionally substituted with a group such as halogeno, trifluoromethyl and cyano, or a group of the formula: Q3—X1— wherein X1 includes a direct bond and O and Q3includes aryl, aryl-(1-6C)alkyl, heterocyclyl and heterocyclyl-(1-6C)alkyl; each of R2 and R3 is hydrogen or (1-6C)alkyl; Z includes O, S and NH; and Q2 includes aryl and aryl-(1-3C)alkyl or a pharmaceutically-acceptable salt thereof, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human.

Abstract: An automatic machine for peening the tenons on bucket cover plates to secure the cover plates and adjacent buckets of a turbine wheel to one another is provided. The machine includes a fixture having stepped surfaces for locating the freely suspended fixture and peening tool relative to the bucket tips and cover plates and clamping the tips and cover plates to the fixture surfaces. After peening a first tenon, the fixture and tool head are displaced relative to the fixed cover plate and bucket tip to register the tool with a second tenon. An actuator displaces the suspended system to compensate for the movement of the fixture and tool relative to the turbine wheel. A counterbalance is provided to accommodate fixtures of different weights when peening the tenons of covers in different turbine wheels.

Abstract: A control system and calibration method are provided for a vehicle drive line having an automated master friction clutch. The control system utilizes engine torque data supplied by a serial communication data link to identify a clutch control parameter value corresponding to an urge-to-move position of the clutch. The clutch control parameter value identified by the calibration method is stored and utilized by the control system to control the engagement position of the automated clutch in an “urge to move” mode of operation. The inventive calibration method can be utilized across multiple vehicle platforms having different engine, clutch and transmission system components.

Abstract: An automatic machine for peening the tenons on bucket cover plates to secure the cover plates and adjacent buckets of a turbine wheel to one another is provided. The machine includes a fixture having stepped surfaces for locating the freely suspended fixture and peening tool relative to the bucket tips and cover plates and clamping the tips and cover plates to the fixture surfaces. After peening a first tenon, the fixture and tool head are displaced relative to the fixed cover plate and bucket tip to register the tool with a second tenon. An actuator displaces the suspended system to compensate for the movement of the fixture and tool relative to the turbine wheel. A counterbalance is provided to accommodate fixtures of different weights when peening the tenons of covers in different turbine wheels.

Abstract: A control system and calibration method are provided for a vehicle drive line having an automated master friction clutch. The control system utilizes engine torque data supplied by a serial communication data link to identify a clutch control parameter value corresponding to an urge-to-move position of the clutch. The clutch control parameter value identified by the calibration method is stored and utilized by the control system to control the engagement position of the automated clutch in an “urge to move” mode of operation. The inventive calibration method can be utilized across multiple vehicle platforms having different engine, clutch and transmission system components.

Abstract: A control system and calibration method are provided for a vehicle drive line having an automated master friction clutch. The control system utilizes engine torque data supplied by a serial communication data link to identify a clutch control parameter value corresponding to an urge-to-move position of the clutch. The clutch control parameter value identified by the calibration method is stored and utilized by the control system to control the engagement position of the automated clutch in an “urge to move” mode of operation. The inventive calibration method can be utilized across multiple vehicle platforms having different engine, clutch and transmission system components.

Abstract: An automatic machine for peening the tenons on bucket cover plates to secure the cover plates and adjacent buckets of a turbine wheel to one another is provided. The machine includes a fixture having stepped surfaces for locating the freely suspended fixture and peening tool relative to the bucket tips and cover plates and clamping the tips and cover plates to the fixture surfaces. After peening a first tenon, the fixture and tool head are displaced relative to the fixed cover plate and bucket tip to register the tool with a second tenon. An actuator displaces the suspended system to compensate for the movement of the fixture and tool relative to the turbine wheel. A counterbalance is provided to accommodate fixtures of different weights when peening the tenons of covers in different turbine wheels.

Abstract: An automatic machine for peening the tenons on bucket cover plates to secure the cover plates and adjacent buckets of a turbine wheel to one another is provided. The machine includes a fixture having stepped surfaces for locating the freely suspended fixture and peening tool relative to the bucket tips and cover plates and clamping the tips and cover plates to the fixture surfaces. After peening a first tenon, the fixture and tool head are displaced relative to the fixed cover plate and bucket tip to register the tool with a second tenon. An actuator displaces the suspended system to compensate for the movement of the fixture and tool relative to the turbine wheel. A counterbalance is provided to accommodate fixtures of different weights when peening the tenons of covers in different turbine wheels.

Abstract: A system for controlling apparatus processing a signal representing a television program comprises a source of schedule data comprising at least data representing the time remaining in a television program. Television signal processing apparatus selectively processes the television program representative signal in response to a control signal. A control circuit generates the control signal to condition the processing apparatus to begin processing the television program signal in response to a user control signal, and to stop processing the television program signal when the time remaining in the television program has elapsed, in response to the program schedule data.