Abstract: A storage container system includes rolling toolbox, a storage container, a storage bin, and a storage container assembly. Various aspects relate to a storage container including at least one sidewall extending from a base, the sidewall at least partially defining an outer wall of an interior compartment. A lid is coupled to the sidewall and movable between an open position and a closed position. The interior compartment is accessible while the lid is in the open position, and the interior compartment is covered while the lid is in the closed position.

Abstract: Examples disclosed herein relate to a finishing system for a three-dimensional (3D) printed part. Example systems include a sensor to detect a marking on a portion of the 3D printed part. A post-processing component of the system may perform a finishing operation on the portion of the 3D printed part while the marking is detected on the 3D printed part.

Abstract: Examples disclosed herein relate to a finishing system for a three-dimensional (3D) printed part. Example systems include a sensor to detect a marking on a portion of the 3D printed part. A post-processing component of the system may perform a finishing operation on the portion of the 3D printed part while the marking is detected on the 3D printed part.

Abstract: A compensation circuit is configured to compensate for a loss of low-frequency signal content of an input signal at a receiver input. The compensation circuit includes a switching circuit and a summing circuit coupled to the switching circuit. The switching circuit is configured to receive a first plurality of digitized values sampled from a receiver output signal. The summing circuit is configured to generate a summation signal based on a combination of a first plurality of input values selected by the switching circuit. The selecting is based on the first plurality of digitized values. The compensation circuit is configured to provide to the receiver input a compensation signal to compensate for the loss of the low-frequency signal content from the input signal. The compensation signal is based on the summation signal and is a function of at least one gain value.

Abstract: A compensation circuit is configured to compensate for a loss of low-frequency signal content of an input signal at a receiver input. The compensation circuit includes a switching circuit and a summing circuit coupled to the switching circuit. The switching circuit is configured to receive a first plurality of digitized values sampled from a receiver output signal. The summing circuit is configured to generate a summation signal based on a combination of a first plurality of input values selected by the switching circuit. The selecting is based on the first plurality of digitized values. The compensation circuit is configured to provide to the receiver input a compensation signal to compensate for the loss of the low-frequency signal content from the input signal. The compensation signal is based on the summation signal and is a function of at least one gain value.

Abstract: A wide-field optical microscope and method capable of resolving images down to 0.1 {acute over (?)} with a magnification range in excess of 250 million power includes an objective having a primary and a secondary element. A sample is held so that the area of interest is at a location that is closer to the primary element than the focal length of the primary element. The primary element collects and collimates light reflected from the sample. The secondary element then focuses the collimated light onto a pinhole aperture, which blocks all light rays that were not parallel, thus producing a non-focused reflected pattern. The non-focused reflected pattern passes through a field stop and is then magnified by one or more negative optical elements and additional field stops to produce an enlarged pattern.

Abstract: A wide-field optical microscope and method capable of resolving images down to 0.1 ? with a magnification range in excess of 250 million power includes an objective having a primary and a secondary element. A sample is held so that the area of interest is at a location that is closer to the primary element than the focal length of the primary element. The primary element collects and collimates light reflected from the sample. The secondary element then focuses the collimated light onto a pinhole aperture, which blocks all light rays that were not parallel, thus producing a non-focused reflected pattern. The non-focused reflected pattern passes through a field stop and is then magnified by one or more negative optical elements and additional field stops to produce an enlarged pattern.

Abstract: The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G?CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.

Abstract: The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.

Abstract: The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G? CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.

Abstract: The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport in a cell comprising contacting a cell with an effective amount of a compound that affects hedgehog, thereby affecting cholesterol biosynthesis or transport. The effect may be inhibition or stimulation of cholesterol biosynthesis or transport.

Abstract: The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G?CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.

Abstract: The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G?CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.

Abstract: The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.

Abstract: The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G?CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.

Abstract: A system and method is provided for bit eye center retraining. In general, the system samples an incoming data stream to determine where transitions in the data stream occur, selectively compares the location of the transitions to the expected locations to produce difference values, and combines pairs of difference values to determine when the sample point of the data stream needs to be adjusted.

Abstract: The present invention relates to the use of TGF-? antagonists for the treatment, amelioration, and diagnosis of parathyroid-related disorders, e.g., HPT-JT, familial isolated primary hyperparathyroidism (FIPH), and hyperparathyroidism-jaw tumor (HPT-JT) syndrome, as well as its attendant complications. The present invention also relates to the use of modulators of HRPT2 and its related PAF1 complex for the treatment, amelioration, and diagnosis of TGF?-related disorders, e.g., pulmonary hypertension, cancer, hypertension, fibrosis, wound healing. Assays of the identification of modulators of HRPT2/PAF1 and SMAD/TGF? are also provided.

Abstract: The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G?CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.

Abstract: The present invention makes available assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.