Abstract: This document describes implantable medical device systems and methods of using such devices for delivering therapy via temperature modulation. For example, this document describes medical device systems and related methods for the treatment of cardiac arrhythmias by delivering cooling to epicardial tissue. In some embodiments described herein, arrhythmias can be treated by an implantable system for painlessly terminating arrhythmias. The devices and methods provided herein permit prompt termination of atrial fibrillation almost immediately after an episode begins (to prevent persistence) and are effective irrespective of patient age and comorbidities.

Abstract: This document describes implantable medical devices and methods of using such devices. The implantable medical devices include a cardiac lead sized for insertion in a cardiac cavity, the cardiac lead having a distal end and a proximal end and a lead body extending therebetween, a heat exchange module disposed at the distal end of the lead body, the heat exchange module comprising an enclosure having a first surface and a second surface, and one or more temperature sensors located within the enclosure.