Patents by Inventor Jeffrey Stults

Jeffrey Stults has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the manufacturing of medicaments
    Patent number: 11098028
    Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: August 24, 2021
    Assignee: Genentech, Inc.
    Inventors: Jinguang Lin, Alexandra Chestakova, Wei Gu, Hans Iding, Jing Li, Xin Linghu, Patrik Meier, Chunbo Sha, Jeffrey Stults, Youchu Wang, Haiming Zhang, Jianqian Zhang, Tao Zhang
  • Process for the manufacturing of medicaments
    Patent number: 11066389
    Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: July 20, 2021
    Assignee: Genentech, Inc.
    Inventors: Jinguang Lin, Alexandra Chestakova, Wei Gu, Hans Iding, Jing Li, Xin Linghu, Patrik Meier, Chunbo Sha, Jeffrey Stults, Youchu Wang, Haiming Zhang, Jianqian Zhang, Tao Zhang
  • PROCESS FOR THE MANUFACTURING OF MEDICAMENTS
    Publication number: 20200190061
    Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid
    Type: Application
    Filed: December 18, 2019
    Publication date: June 18, 2020
    Applicant: Genentech, Inc.
    Inventors: JINGUANG LIN, ALEXANDRA CHESTAKOVA, WEI GU, HANS IDING, JING LI, XIN LINGHU, PATRIK MEIER, CHUNBO SHA, JEFFREY STULTS, YOUCHU WANG, HAIMING ZHANG, JIANQIAN ZHANG, TAO ZHANG
  • Process for the manufacturing of medicaments
    Patent number: 10611753
    Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: April 7, 2020
    Assignee: Genentech, Inc.
    Inventors: Jinguang Lin, Alexandra Chestakova, Wei Gu, Hans Iding, Jing Li, Xin Linghu, Patrik Meier, Chunbo Sha, Jeffrey Stults, Youchu Wang, Haiming Zhang, Jianqian Zhang, Tao Zhang
  • PROCESS FOR THE MANUFACTURING OF MEDICAMENTS
    Publication number: 20190367484
    Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid
    Type: Application
    Filed: August 8, 2019
    Publication date: December 5, 2019
    Applicant: Genentech, Inc.
    Inventors: JINGUANG LIN, ALEXANDRA CHESTAKOVA, WEI GU, HANS IDING, JING LI, XIN LINGHU, PATRIK MEIER, CHUNBO SHA, JEFFREY STULTS, YOUCHU WANG, HAIMING ZHANG, JIANQIAN ZHANG, TAO ZHANG
  • CRYSTALLINE FORMS OF A PYRROLOPYRIDINE COMPOUND
    Publication number: 20180282324
    Abstract: Disclosed are crystalline forms of (R)—N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide, and salts, solvates, and hydrates thereof, and pharmaceutical compositions, formulations and a process of manufacturing thereof.
    Type: Application
    Filed: November 8, 2017
    Publication date: October 4, 2018
    Applicants: Genentech, Inc., Array Biopharma Inc.
    Inventors: Jeffrey Stults, Christopher M. Lindemann, Keith L. Spencer, Weidong Liu, Joseph Lubach
  • PROCESS FOR THE MANUFACTURING OF MEDICAMENTS
    Publication number: 20180134685
    Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid
    Type: Application
    Filed: January 10, 2018
    Publication date: May 17, 2018
    Applicant: Genentech, Inc.
    Inventors: Jinguang Lin, Alexandra Chestakova, Wei Gu, Hans Iding, Jing Li, Xin Linghu, Patrik Meier, Chunbo Sha, Jeffrey Stults, Youchu Wang, Haiming Zhang, Jianqian Zhang, Tao Zhang
  • PROCESS FOR THE MANUFACTURING OF MEDICAMENTS
    Publication number: 20170022183
    Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid
    Type: Application
    Filed: October 5, 2016
    Publication date: January 26, 2017
    Applicant: Genentech, Inc.
    Inventors: Jinguang Lin, Alexandra Chestakova, Wei Gu, Hans Iding, Jing Li, Xin Linghu, Patrik Meier, Chunbo Sha, Jeffrey Stults, Youchu Wang, Haiming Zhang, Jianqian Zhang, Tao Zhang
  • Crystalline and mesomorphous forms of an AKT inhibiting pyrimidinyl-cyclopentane compound, compositions and methods thereof
    Patent number: 9505725
    Abstract: Disclosed is (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one monohydrochloride, forms, formulations, pharmaceutical compositions, processes of manufacturing and methods of use thereof.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: November 29, 2016
    Assignee: GENENTECH, INC.
    Inventors: Paroma Chakravarty, Sanjeev Kothari, Francis Gosselin, Scott J. Savage, Jeffrey Stults
  • Polymorphs of 2-(4-(2-(1-(isopropyl-3-methyl-1H-1,2,4,triazol-5-yl)-5,6-dihydrobenzo[f] imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide, methods of production, and pharmaceutical uses thereof
    Patent number: 9481690
    Abstract: The present invention relates to crystalline polymorphs of (2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide (GDC-0032, taselisib), methods of use, and processes of preparing thereof.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: November 1, 2016
    Assignee: Genentech, Inc.
    Inventors: Jeffrey Stults, Travis Remarchuk, Frederic St-Jean
  • CRYSTALLINE FORMS OF A PYRROLOPYRIDINE COMPOUND
    Publication number: 20160251350
    Abstract: Disclosed are crystalline forms of (R)—N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide, and salts, solvates, and hydrates thereof, and pharmaceutical compositions, formulations and a process of manufacturing thereof.
    Type: Application
    Filed: February 26, 2016
    Publication date: September 1, 2016
    Applicants: Genentech, Inc., Array Biopharma Inc.
    Inventors: Jeffrey Stults, Christopher M. Lindemann, Keith L. Spencer, Weidong Liu, Joseph Lubach
  • POLYMORPHS OF 2-(4-(2-(1-ISOPROPYL-3-METHYL-1H-1,2,4-TRIAZOL-5-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)-1H-PYRAZOL-1-YL)-2-METHYLPROPANAMIDE, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF
    Publication number: 20160222027
    Abstract: The present invention relates to crystalline polymorphs of (2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide (GDC-0032, taselisib), methods of use, and processes of preparing thereof.
    Type: Application
    Filed: January 8, 2016
    Publication date: August 4, 2016
    Applicant: Genentech, Inc.
    Inventors: Jeffrey Stults, Travis Remarchuk, Frederic St-Jean
  • AMORPHOUS FORM OF AN AKT INHIBITING PYRIMIDINYL-CYCLOPENTANE COMPOUND, COMPOSITIONS AND METHODS THEREOF
    Publication number: 20160152575
    Abstract: Disclosed is (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one monohydrochloride, forms, formulations, pharmaceutical compositions, processes of manufacturing and methods of use thereof.
    Type: Application
    Filed: February 8, 2016
    Publication date: June 2, 2016
    Applicant: Genentech, Inc.
    Inventors: Paroma Chakravarty, Sanjeev Kothari, Francis Gosselin, Scott J. Savage, Jeffrey Stults
  • Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof
    Patent number: 9315471
    Abstract: The invention provides new processes for making and purifying salts of hydroxylated cyclopentapyrimidine compounds, which are useful as AKT inhibitors used in the treatment of diseases such as cancer, including the monohydrochloride salt of (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: April 19, 2016
    Assignee: GENETECH, INC.
    Inventors: Srinivasan Babu, Francis Gosselin, Yingqing Ran, Travis Remarchuk, Scott J. Savage, Jeffrey Stults, Herbert Yajima
  • Amorphous form of an AKT inhibiting pyrimidinyl-cyclopentane compound, compositions and methods thereof
    Patent number: 9290458
    Abstract: Disclosed is (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one monohydrochloride, forms, formulations, pharmaceutical compositions, processes of manufacturing and methods of use thereof.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: March 22, 2016
    Assignee: GENENTECH, INC.
    Inventors: Paroma Chakravarty, Sanjeev Kothari, Francis Gosselin, Scott J. Savage, Jeffrey Stults
  • Polymorphs of 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazole-5-yl)-5,6-dihydrobenzo[F]imidazo [1,2-D][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide, methods of production, and pharmaceutical uses thereof
    Patent number: 9266903
    Abstract: The present invention relates to crystalline polymorphs of (2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide (GDC-0032, taselisib), methods of use, and processes of preparing thereof.
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: February 23, 2016
    Assignee: Genentech, Inc.
    Inventor: Jeffrey Stults
  • AMORPHOUS FORM OF AN AKT INHIBITING PYRIMIDINYL-CYCLOPENTANE COMPOUND, COMPOSITIONS AND METHODS THEREOF
    Publication number: 20150274677
    Abstract: Disclosed is (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one monohydrochloride, forms, formulations, pharmaceutical compositions, processes of manufacturing and methods of use thereof.
    Type: Application
    Filed: May 17, 2012
    Publication date: October 1, 2015
    Inventors: Paroma Chakravarty, Sanjeev Kothari, Francis Gosselin, Scott J. Savage, Jeffrey Stults
  • POLYMORPHS OF 2-(4-(2-(1-ISOPROPYL-3-METHYL-1H-1,2,4-TRIAZOL-5-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)-1H-PYRAZOL-1-YL)-2-METHYLPROPANAMIDE, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF
    Publication number: 20150166570
    Abstract: The present invention relates to crystalline polymorphs of (2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide (GDC-0032, taselisib), methods of use, and processes of preparing thereof.
    Type: Application
    Filed: December 15, 2014
    Publication date: June 18, 2015
    Applicant: GENENTECH, INC.
    Inventor: Jeffrey Stults
  • PROCESS OF MAKING HYDROXYLATED CYCLOPENTAPYRIMIDINE COMPOUNDS AND SALTS THEREOF
    Publication number: 20150099880
    Abstract: The invention provides new processes for making and purifying salts of hydroxylated cyclopentapyrimidine compounds, which are useful as AKT inhibitors used in the treatment of diseases such as cancer, including the monohydrochloride salt of (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one.
    Type: Application
    Filed: May 17, 2013
    Publication date: April 9, 2015
    Applicant: Genetech, Inc.
    Inventors: Srinivasan Babu, Francis Gosselin, Yingqing Ran, Travis Remarchuk, Scott J. Savage, Jeffrey Stults, Herbert Yajima
  • ROMIDEPSIN SOLID FORMS AND USES THEREOF
    Publication number: 20120190817
    Abstract: The present disclosure provides solid forms of a compound of formula I. In some embodiments, the present disclosure provides crystalline forms of Compound I. In some embodiments, the present disclosure provides solvate forms of Compound I. In some embodiments, the present disclosure provides amorphous Compound I.
    Type: Application
    Filed: July 12, 2011
    Publication date: July 26, 2012
    Applicant: Celgene Corporation
    Inventors: Jason Hanko, David Engers, Eric Hagen, Valeriya Smolenskaya, Jeffrey Stults