Abstract: Methods and devices for tissue remodeling and repair of collagenous tissues, including tendons, ligaments, and bone, as well as scalable connective tissue manufacturing, are provided. Collagen fibers are assembled by extensional strain-induced flow crystallization of collagen monomers. Extensional strain also drives the fusion of already formed short collagen fibrils to produce long-range, continuous fibers. Wearable devices for controlled tissue remodeling and wound healing deliver a tissue remodeling solution to a tissue repair site. The remodeling solution, together with appropriate application of strain to the tissue remodeling site, accelerate healing, prevent injury, and reduce scar formation.

Abstract: Methods and devices are described for using a controlled extensional strain to organize prefibrillar collagen and/or elastin solutions into an organized array of fibrils. The organized array of collagen fibrils produced by the disclosed methods and devices can be used for tissue engineering applications.

Abstract: Methods and devices are described for using a controlled extensional strain to organize prefibrillar collagen and/or elastin solutions into an organized array of fibrils. The organized array of collagen fibrils produced by the disclosed methods and devices can be used for tissue engineering applications.

Abstract: Methods and devices are described for using a controlled extensional strain to organize prefibrillar collagen and/or elastin solutions into an organized array of fibrils. The organized array of collagen fibrils produced by the disclosed methods and devices can be used for tissue engineering applications.

Abstract: Methods and devices for tissue remodeling and repair of collagenous tissues, including tendons, ligaments, and bone, as well as scalable connective tissue manufacturing, are provided. Collagen fibers are assembled by extensional strain-induced flow crystallization of collagen monomers. Extensional strain also drives the fusion of already formed short collagen fibrils to produce long-range, continuous fibers. Wearable devices for controlled tissue remodeling and wound healing deliver a tissue remodeling solution to a tissue repair site. The remodeling solution, together with appropriate application of strain to the tissue remodeling site, accelerate healing, prevent injury, and reduce scar formation.

Abstract: Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engineering.

Abstract: Methods and compositions are described for organizing nanoparticles or microparticles into nanostructures or microstructures using collagen as a template.

Abstract: Methods and devices are described for using a controlled extensional strain to organize prefibrillar collagen and/or elastin solutions into an organized array of fibrils. The organized array of collagen fibrils produced by the disclosed methods and devices can be used for tissue engineering applications.

Abstract: Methods and compositions are described for organizing nanoparticles or microparticles into nanostructures or microstructures using collagen as a template.

Abstract: Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engineering.

Abstract: Disclosed herein are methods and systems for evaluating and modeling fibrous structures from one or more images. The methods and systems allow for robust, independent, and accurate quantification of fiber orientation in complicated structures, such as the undulating, interweaving, and multidirectional fibers of the human cornea. In addition, the methods and systems can be used to study, repair, and perform quality control on existing biological and industrial structures that include fibers (e.g., carbon nanotubes). Some embodiments can be used to predict the properties (e.g., strength, contrast, and material degradation) of and engineer new biological and industrial structures with fibers (e.g., synthetic corneas).

Abstract: Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engineering.

Abstract: Methods and compositions are described for organizing nanoparticles or microparticles into nanostructures or microstructures using collagen as a template.

Abstract: Disclosed herein are methods and devices for preserving a sample for histological analysis, in particular embodiments, the disclosed methods and devices allow for contacting a surface with the sample at a contact velocity of between 0.05 cm/s to 10 cm/s.

Abstract: Disclosed herein are devices and methods for fast and simple generation of an anastomosis. In certain embodiments, the devices and methods involve the deployment of self-expanding stents without the use of a catheter. The devices and methods disclosed herein further utilize a sheath that allows an operator to deploy the stent without the use of an inter-lumen device.

Abstract: Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engineering.

Abstract: Systems, devices, and methods are provided for assembling polymer-forming molecular components such that highly-structured arrays of polymer strands, such as collagen fibrils, are formed without the need for cells. A polymer nanoloom is designed to control the self-assembly of monomers into fibrils and related tissue constructs including ligament, tendon, cartilage, and bone. A nanoloom system comprises a polymer printhead, a temperature controller, and a movable substrate for polymer printing. A polymer printhead contains one or more nanoreactors that can control the assembly of collagen fibrils or other polymers on a nanoscale. Methods are provided for temperature-driven, enzyme-driven, and cholesteric assembly of collagen or other polymers into two- or three-dimensional tissue constructs.

Abstract: The present invention provides methods of making covalently crosslinked vinyl polymer hydrogels having advantageous physical properties, and covalently crosslinked vinyl polymer hydrogel compositions made by such methods, as well as articles of manufacture comprising such covalently crosslinked vinyl polymer hydrogel compositions. The physical properties of the produced hydrogels can be adjusted by varying controlled parameters such as the proportion of physical associations, the concentration of polymer and the amount of radiation applied. Such covalently crosslinked vinyl polymer hydrogels can be made translucent, preferably transparent, or opaque depending on the processing conditions. The stability of the physical properties of the produced vinyl polymer hydrogel can be enhanced by controlling the amount of covalent crosslinks.

Abstract: Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engineering.

Abstract: In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex.